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Duke Geem, MD, PhD
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Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source …
TL Denning, BA Norris, O Medina-Contreras, S Manicassamy, D Geem, ...
The Journal of Immunology 187 (2), 733-747, 2011
3932011
CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice
O Medina-Contreras, D Geem, O Laur, IR Williams, SA Lira, A Nusrat, ...
The Journal of clinical investigation 121 (12), 4787-4795, 2011
3342011
Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis
H Laroui, E Viennois, B Xiao, BSB Canup, D Geem, TL Denning, D Merlin
Journal of Controlled Release 186, 41-53, 2014
1492014
Cutting edge: IL-36 receptor promotes resolution of intestinal damage
O Medina-Contreras, A Harusato, H Nishio, KL Flannigan, V Ngo, G Leoni, ...
The journal of immunology 196 (1), 34-38, 2016
1352016
T lymphocytes and vascular inflammation contribute to stress-dependent hypertension
PJ Marvar, A Vinh, S Thabet, HE Lob, D Geem, KJ Ressler, DG Harrison
Biological psychiatry 71 (9), 774-782, 2012
1202012
IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria
KL Flannigan, VL Ngo, D Geem, A Harusato, SA Hirota, CA Parkos, ...
Mucosal immunology 10 (3), 673-684, 2017
1192017
Targeting intestinal inflammation with CD98 siRNA/PEI–loaded nanoparticles
H Laroui, D Geem, B Xiao, E Viennois, P Rakhya, T Denning, D Merlin
Molecular Therapy 22 (1), 69-80, 2014
1172014
A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage
VL Ngo, H Abo, E Maxim, A Harusato, D Geem, O Medina-Contreras, ...
Proceedings of the National Academy of Sciences 115 (22), E5076-E5085, 2018
972018
Isolation and characterization of dendritic cells and macrophages from the mouse intestine
D Geem, O Medina-Contreras, W Kim, CS Huang, TL Denning
JoVE (Journal of Visualized Experiments), e4040, 2012
762012
Intestinal antigen-presenting cells: key regulators of immune homeostasis and inflammation
KL Flannigan, D Geem, A Harusato, TL Denning
The American journal of pathology 185 (7), 1809-1819, 2015
622015
Cortisol, stress, and attentional bias toward threat
RK McHugh, E Behar, CA Gutner, D Geem, MW Otto
Anxiety, Stress, & Coping 23 (5), 529-545, 2010
582010
Small intestinal intraepithelial TCRγδ+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis
JH Weitkamp, MJ Rosen, Z Zhao, T Koyama, D Geem, TL Denning, ...
PLoS One 9 (6), e99042, 2014
572014
Specific microbiota-induced intestinal Th17 differentiation requires MHC class II but not GALT and mesenteric lymph nodes
D Geem, O Medina-Contreras, M McBride, RD Newberry, PA Koni, ...
The Journal of Immunology 193 (1), 431-438, 2014
522014
Harnessing regulatory T cells for the treatment of inflammatory bowel disease
D Geem, A Harusato, K Flannigan, TL Denning
Inflammatory bowel diseases 21 (6), 1409-1418, 2015
472015
The “bridging” aspartate 178 in phthalate dioxygenase facilitates interactions between the Rieske center and the iron (II)− mononuclear center
M Tarasev, A Pinto, D Kim, SJ Elliott, DP Ballou
Biochemistry 45 (34), 10208-10216, 2006
342006
Macrophage isolation from the mouse small and large intestine
A Harusato, D Geem, TL Denning
Gastrointestinal Physiology and Diseases: Methods and Protocols, 171-180, 2016
272016
Contribution of mesenteric lymph nodes and GALT to the intestinal Foxp3+ regulatory T-cell compartment
D Geem, V Ngo, A Harusato, B Chassaing, AT Gewirtz, RD Newberry, ...
Cellular and molecular gastroenterology and hepatology 2 (3), 274-280. e3, 2016
172016
Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3+ Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis
H Abo, KL Flannigan, D Geem, VL Ngo, A Harusato, TL Denning
Frontiers in immunology 10, 459, 2019
162019
Phenotypic and functional profiling of mouse intestinal antigen presenting cells
A Harusato, KL Flannigan, D Geem, TL Denning
Journal of immunological methods 421, 20-26, 2015
142015
Assessing cellular and transcriptional diversity of ileal mucosa among treatment-naïve and treated Crohn’s disease
SC Maddipatla, VL Kolachala, S Venkateswaran, AF Dodd, RS Pelia, ...
Inflammatory Bowel Diseases 29 (2), 274-285, 2023
112023
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