| International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1,-2, and-3: pharmacology and pathophysiological functions LA Stoddart, NJ Smith, G Milligan Pharmacological reviews 60 (4), 405-417, 2008 | 364 | 2008 |
| Allostery at G protein-coupled receptor homo-and heteromers: uncharted pharmacological landscapes NJ Smith, G Milligan Pharmacological reviews 62 (4), 701-725, 2010 | 309 | 2010 |
| Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements R Schröder, N Janssen, J Schmidt, A Kebig, N Merten, S Hennen, ... Nature biotechnology 28 (9), 943-949, 2010 | 290 | 2010 |
| Allosteric modulation of heterodimeric G-protein-coupled receptors G Milligan, NJ Smith Trends in pharmacological sciences 28 (12), 615-620, 2007 | 194 | 2007 |
| Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes JW McNamara, A Li, NJ Smith, S Lal, RM Graham, KB Kooiker, ... Journal of molecular and cellular cardiology 94, 65-71, 2016 | 129 | 2016 |
| Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3 J Schmidt, NJ Smith, E Christiansen, IG Tikhonova, M Grundmann, ... Journal of Biological Chemistry 286 (12), 10628-10640, 2011 | 128 | 2011 |
| Angiotensin1‐9 antagonises pro‐hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor M Flores‐Muñoz, NJ Smith, C Haggerty, G Milligan, SA Nicklin The journal of Physiology 589 (4), 939-951, 2011 | 125 | 2011 |
| Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short … LA Stoddart, NJ Smith, L Jenkins, AJ Brown, G Milligan Journal of biological chemistry 283 (47), 32913-32924, 2008 | 114 | 2008 |
| Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13 L Jenkins, J Brea, NJ Smith, BD Hudson, G Reilly, NJ Bryant, M Castro, ... Biochemical journal 432 (3), 451-459, 2010 | 108 | 2010 |
| Identifying ligands at orphan GPCRs: current status using structure‐based approaches T Ngo, I Kufareva, JLJ Coleman, RM Graham, R Abagyan, NJ Smith British journal of pharmacology 173 (20), 2934-2951, 2016 | 94 | 2016 |
| The Action and Mode of Binding of Thiazolidinedione Ligands at Free Fatty Acid Receptor 1*♦ NJ Smith, LA Stoddart, NM Devine, L Jenkins, G Milligan Journal of biological chemistry 284 (26), 17527-17539, 2009 | 85 | 2009 |
| Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator NJ Smith, RJ Ward, LA Stoddart, BD Hudson, E Kostenis, T Ulven, ... Molecular pharmacology 80 (1), 163-173, 2011 | 79 | 2011 |
| When simple agonism is not enough: emerging modalities of GPCR ligands NJ Smith, KA Bennett, G Milligan Molecular and cellular endocrinology 331 (2), 241-247, 2011 | 73 | 2011 |
| Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3 G Milligan, LA Stoddart, NJ Smith British journal of pharmacology 158 (1), 146-153, 2009 | 71 | 2009 |
| What’s new in the renin-angiotensin system? Hijacking epidermal growth factor receptors by angiotensin II: new possibilities for understanding and treating cardiac hypertrophy NJ Smith, HW Chan, JE Osborne, WG Thomas, RD Hannan Cellular and Molecular Life Sciences CMLS 61, 2695-2703, 2004 | 61 | 2004 |
| RETRACTED ARTICLE: Orphan receptor ligand discovery by pickpocketing pharmacological neighbors T Ngo, AV Ilatovskiy, AG Stewart, JLJ Coleman, FM McRobb, RP Riek, ... Nature chemical biology 13 (2), 235-242, 2017 | 59* | 2017 |
| High-throughput phenotyping of heteromeric human ether-a-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants CA Ng, MD Perry, W Liang, NJ Smith, B Foo, A Shrier, GL Lukacs, AP Hill, ... Heart rhythm 17 (3), 492-500, 2020 | 56 | 2020 |
| Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors BD Hudson, NJ Smith, G Milligan Advances in pharmacology 62, 175-218, 2011 | 53 | 2011 |
| Signal switching, crosstalk, and arrestin scaffolds: novel G protein–coupled receptor signaling in cardiovascular disease NJ Smith, LM Luttrell Hypertension 48 (2), 173-179, 2006 | 53 | 2006 |
| Cryo-EM reveals distinct conformations of E. coli ATP synthase on exposure to ATP M Sobti, R Ishmukhametov, JC Bouwer, A Ayer, C Suarna, NJ Smith, ... Elife 8, e43864, 2019 | 49 | 2019 |
