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Michelle L Halls
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Relaxin family peptides and their receptors
RAD Bathgate, ML Halls, ET van der Westhuizen, GE Callander, M Kocan, ...
Physiological reviews 93 (1), 405-480, 2013
4292013
Regulation by Ca2+-signaling pathways of adenylyl cyclases
ML Halls, DMF Cooper
Cold Spring Harbor perspectives in biology 3 (1), a004143, 2011
1742011
Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2
I Mookerjee, TD Hewitson, ML Halls, RJ Summers, ML Mathai, ...
The FASEB journal 23 (4), 1219-1229, 2009
1402009
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
A Gillis, AB Gondin, A Kliewer, J Sanchez, HD Lim, C Alamein, ...
Science Signaling 13 (625), eaaz3140, 2020
1372020
Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms
ML Halls, RAD Bathgate, RJ Summers
Molecular pharmacology 70 (1), 214-226, 2006
1292006
Relaxin family peptide receptors–former orphans reunite with their parent ligands to activate multiple signalling pathways
ML Halls, ET van der Westhuizen, RAD Bathgate, RJ Summers
British journal of pharmacology 150 (6), 677-691, 2007
1242007
Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling
D Willoughby, KL Everett, ML Halls, J Pacheco, P Skroblin, L Vaca, ...
Science signaling 5 (219), ra29-ra29, 2012
1212012
Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8)
ML Halls, CP Bond, S Sudo, J Kumagai, T Ferraro, S Layfield, ...
Journal of Pharmacology and Experimental Therapeutics 313 (2), 677-687, 2005
1152005
International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1 …
ML Halls, RAD Bathgate, SW Sutton, TB Dschietzig, RJ Summers
Pharmacological Reviews 67 (2), 389-440, 2015
1132015
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief
DD Jensen, TM Lieu, ML Halls, NA Veldhuis, WL Imlach, QN Mai, ...
Science Translational Medicine 9 (392), eaal3447, 2017
1102017
Ligand-dependent modulation of G protein conformation alters drug efficacy
SGB Furness, YL Liang, CJ Nowell, ML Halls, PJ Wookey, E Dal Maso, ...
Cell 167 (3), 739-749. e11, 2016
1012016
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission
RE Yarwood, WL Imlach, TM Lieu, NA Veldhuis, DD Jensen, ...
Proceedings of the National Academy of Sciences 114 (46), 12309-12314, 2017
902017
Sub‐picomolar relaxin signalling by a pre‐assembled RXFP1, AKAP79, AC2, β‐arrestin 2, PDE4D3 complex
ML Halls, DMF Cooper
The EMBO journal 29 (16), 2772-2787, 2010
882010
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
NN Jimenez-Vargas, LA Pattison, P Zhao, TM Lieu, R Latorre, DD Jensen, ...
Proceedings of the National Academy of Sciences 115 (31), E7438-E7447, 2018
872018
Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
EE To, R Vlahos, R Luong, ML Halls, PC Reading, PT King, C Chan, ...
Nature communications 8 (1), 1-17, 2017
812017
Adenylyl cyclase signalling complexes–pharmacological challenges and opportunities
ML Halls, DMF Cooper
Pharmacology & therapeutics 172, 171-180, 2017
812017
Relaxin family peptide receptors–from orphans to therapeutic targets
ET van der Westhuizen, ML Halls, CS Samuel, RAD Bathgate, ...
Drug discovery today 13 (15-16), 640-651, 2008
792008
AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems
D Willoughby, N Masada, S Wachten, M Pagano, ML Halls, KL Everett, ...
Journal of Biological Chemistry 285 (26), 20328-20342, 2010
772010
Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization
E Miess, AB Gondin, A Yousuf, R Steinborn, N Mösslein, Y Yang, ...
Science signaling 11 (539), eaas9609, 2018
762018
Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling
ML Halls, HR Yeatman, CJ Nowell, GL Thompson, AB Gondin, ...
Science signaling 9 (414), ra16-ra16, 2016
632016
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