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Michelle L Halls
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Relaxin family peptides and their receptors
RAD Bathgate, ML Halls, ET van der Westhuizen, GE Callander, M Kocan, ...
Physiological reviews 93 (1), 405-480, 2013
5362013
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
A Gillis, AB Gondin, A Kliewer, J Sanchez, HD Lim, C Alamein, ...
Science signaling 13 (625), eaaz3140, 2020
2422020
Regulation by Ca2+-signaling pathways of adenylyl cyclases
ML Halls, DMF Cooper
Cold Spring Harbor perspectives in biology 3 (1), a004143, 2011
2222011
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief
DD Jensen, TM Lieu, ML Halls, NA Veldhuis, WL Imlach, QN Mai, ...
Science Translational Medicine 9 (392), eaal3447, 2017
1872017
Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2
I Mookerjee, TD Hewitson, ML Halls, RJ Summers, ML Mathai, ...
The FASEB journal 23 (4), 1219-1229, 2009
1582009
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission
RE Yarwood, WL Imlach, TM Lieu, NA Veldhuis, DD Jensen, ...
Proceedings of the National Academy of Sciences 114 (46), 12309-12314, 2017
1502017
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
NN Jimenez-Vargas, LA Pattison, P Zhao, TM Lieu, R Latorre, DD Jensen, ...
Proceedings of the National Academy of Sciences 115 (31), E7438-E7447, 2018
1452018
Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms
ML Halls, RAD Bathgate, RJ Summers
Molecular pharmacology 70 (1), 214-226, 2006
1412006
Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling
D Willoughby, KL Everett, ML Halls, J Pacheco, P Skroblin, L Vaca, ...
Science signaling 5 (219), ra29-ra29, 2012
1382012
Relaxin family peptide receptors–former orphans reunite with their parent ligands to activate multiple signalling pathways
ML Halls, ET van der Westhuizen, RAD Bathgate, RJ Summers
British journal of pharmacology 150 (6), 677-691, 2007
1342007
Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
EE To, R Vlahos, R Luong, ML Halls, PC Reading, PT King, C Chan, ...
Nature communications 8 (1), 69, 2017
1312017
International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1 …
ML Halls, RAD Bathgate, SW Sutton, TB Dschietzig, RJ Summers
Pharmacological Reviews 67 (2), 389-440, 2015
1312015
Ligand-dependent modulation of G protein conformation alters drug efficacy
SGB Furness, YL Liang, CJ Nowell, ML Halls, PJ Wookey, E Dal Maso, ...
Cell 167 (3), 739-749. e11, 2016
1252016
Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8)
ML Halls, CP Bond, S Sudo, J Kumagai, T Ferraro, S Layfield, ...
Journal of Pharmacology and Experimental Therapeutics 313 (2), 677-687, 2005
1212005
Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization
E Miess, AB Gondin, A Yousuf, R Steinborn, N Mösslein, Y Yang, ...
Science signaling 11 (539), eaas9609, 2018
1112018
Adenylyl cyclase signalling complexes–Pharmacological challenges and opportunities
ML Halls, DMF Cooper
Pharmacology & therapeutics 172, 171-180, 2017
1052017
β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer
A Chang, CP Le, AK Walker, SJ Creed, CK Pon, S Albold, D Carroll, ...
Brain, behavior, and immunity 57, 106-115, 2016
942016
Sub‐picomolar relaxin signalling by a pre‐assembled RXFP1, AKAP79, AC2, β‐arrestin 2, PDE4D3 complex
ML Halls, DMF Cooper
The EMBO journal 29 (16), 2772-2787, 2010
922010
The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion
CK Pon, JR Lane, EK Sloan, ML Halls
The FASEB Journal 30 (3), 1144, 2016
852016
β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion
SJ Creed, CP Le, M Hassan, CK Pon, S Albold, KT Chan, ME Berginski, ...
Breast cancer research 17, 1-12, 2015
842015
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