| Determination of human hepatocyte intrinsic clearance for slowly metabolized compounds: comparison of a primary hepatocyte/stromal cell co-culture with plated primary … B Bonn, P Svanberg, A Janefeldt, I Hultman, K Grime Drug Metabolism and Disposition 44 (4), 527-533, 2016 | 82 | 2016 |
| Discovery of a novel oral glucocorticoid receptor modulator (AZD9567) with improved side effect profile L Ripa, K Edman, M Dearman, G Edenro, R Hendrickx, V Ullah, ... Journal of Medicinal Chemistry 61 (5), 1785-1799, 2018 | 66 | 2018 |
| Development of a novel lung slice methodology for profiling of inhaled compounds E Bäckström, A Lundqvist, E Boger, P Svanberg, P Ewing, ... Journal of pharmaceutical sciences 105 (2), 838-845, 2016 | 46 | 2016 |
| Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials TH Myrbäck, S Prothon, K Edman, J Leander, M Hashemi, M Dearman, ... The Lancet Rheumatology 2 (1), e31-e41, 2020 | 16 | 2020 |
| Predicting metabolic clearance for drugs that are actively transported into hepatocytes: incubational binding as a consequence of in vitro hepatocyte concentration is a key factor P Nordell, P Svanberg, J Bird, K Grime Drug Metabolism and Disposition 41 (4), 836-843, 2013 | 16 | 2013 |
| Dual role for a MEK inhibitor as a modulator of inflammation and host defense mechanisms with potential therapeutic application in COPD N Kurian, TS Cohen, L Öberg, E De Zan, G Skogberg, S Vollmer, ... International Journal of Chronic Obstructive Pulmonary Disease, 2611-2624, 2019 | 14 | 2019 |
| AZD0284, a potent, selective, and orally bioavailable inverse agonist of retinoic acid receptor-related orphan receptor C2 F Narjes, A Llinas, S von Berg, J Jirholt, S Lever, R Pehrson, M Collins, ... Journal of Medicinal Chemistry 64 (18), 13807-13829, 2021 | 10 | 2021 |
| Hultman Ia, and Grime K (2016) Determination of human hepatocyte intrinsic clearance for slowly metabolized compounds: comparison of a primary hepatocyte/stromal cell co … B Bonn, P Svanberg, A Janefeldt Drug Metab Dispos 44, 527-533, 0 | 10 | |
| Optimized experimental design for the estimation of enzyme kinetic parameters: an experimental evaluation E Sjögren, P Svanberg, KP Kanebratt Drug Metabolism and Disposition 40 (12), 2273-2279, 2012 | 9 | 2012 |
| An S‐warfarin and AZD1981 interaction: in vitro and clinical pilot data suggest the N‐deacetylated amino acid metabolite as the primary perpetrator K Grime, R Pehrson, P Nordell, M Gillen, W Kühn, T Mant, M Brännström, ... British Journal of Clinical Pharmacology 83 (2), 381-392, 2017 | 4 | 2017 |
| SAT0245 Azd9567: a novel oral selective glucocorticoid receptor modulator, demonstrated to have an improved therapeutic ratio compared to prednisolone in pre-clinical studies … R Hendrickx, T Hegelund-Myrbäck, M Dearman, S Prothon, G Edenro, ... Annals of the Rheumatic Diseases 77 (Suppl 2), 984-985, 2018 | 2 | 2018 |
| AZD9567 versus prednisolone in patients with active rheumatoid arthritis: A phase IIa, randomized, double‐blind, efficacy, and safety study JM van Laar, A Lei, M Safy‐Khan, J Almquist, G Belfield, K Edman, ... Clinical and Translational Science 16 (12), 2494-2506, 2023 | | 2023 |
| POS0089 AZD9567 VERSUS PREDNISOLONE IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS: A PHASE 2A, RANDOMISED, DOUBLE-BLIND, PARALLEL-GROUP EFFICACY AND SAFETY STUDY JM Van Laar, A Lei, M Safy-Khan, J Almquist, C Astbury, M Belvisi, A Platt, ... Annals of the Rheumatic Diseases 80 (Suppl 1), 253-254, 2021 | | 2021 |
| SAT0251 Selective glucocorticoid receptor modulator shows potent anti-inflammatory effect with improved metabolic profile in a phase i study supported by in vitro data TH Myrbäck, S Prothon, M Dearman, G Edenro, J Leander, M Hashemi, ... Annals of the Rheumatic Diseases 77 (Suppl 2), 987-987, 2018 | | 2018 |
| Investigating The Activity Of A Rhinovirus Capsid-Binding Compound, Az13694531, On Rhinovirus-C And Rhinovirus-A Replication In Differentiated Primary Airway Epithelial Cells … C McCrae, J Horndahl, P Hazon, R Svärd, P Svanberg, D Keeling C72. EPITHELIAL BIOLOGY, A5899-A5899, 2016 | | 2016 |
| C72 EPITHELIAL BIOLOGY: Investigating The Activity Of A Rhinovirus Capsid-Binding Compound, Az13694531, On Rhinovirus-C And Rhinovirus-A Replication In Differentiated Primary … C McCrae, J Horndahl, P Hazon, R Svärd, P Svanberg, D Keeling American Journal of Respiratory and Critical Care Medicine 193, 1, 2016 | | 2016 |
| Tissue distribution of inhalation drugs in rat lung slices E Bäckström, A Lundqvist, E Boger, P Svanberg, P Ewing, ... European Respiratory Journal 46 (suppl 59), 2015 | | 2015 |
| Development of a lung slice methodology to study the mechanisms of lung uptake and lysosomal trapping E Bäckström, A Lundqvist, P Svanberg, E Boger, P Ewing, ... European Respiratory Journal 44 (Suppl 58), 2014 | | 2014 |
| Low Intrinsic Clearance determination using Primary Human Hepatocytes in monoculture compared to co-culture with non-parenchymal stromal cells. P Svanberg, B Bonn, M Darnell, I Hultman, K Grime | | |
| Determination of Low Intrinsic Clearance Values using Primary Human Hepatocytes and the HepaRG® Cell Line-A Comparison of Methods P Svanberg, B Bonn, A Janefeldt, K Kanebratt, I Hultman, P Courtney, ... | | |
