Philip E. Thompson
Philip E. Thompson
Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University
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Structure− activity relationships of polymyxin antibiotics
T Velkov, PE Thompson, RL Nation, J Li
Journal of medicinal chemistry 53 (5), 1898-1916, 2010
PI 3-kinase p110β: a new target for antithrombotic therapy
SP Jackson, SM Schoenwaelder, I Goncalves, WS Nesbitt, CL Yap, ...
Nature medicine 11 (5), 507-514, 2005
Pharmacology of polymyxins: new insights into an ‘old’class of antibiotics
T Velkov, KD Roberts, RL Nation, PE Thompson, J Li
Future microbiology 8 (6), 711-724, 2013
A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity
ZZ Deris, J Akter, S Sivanesan, KD Roberts, PE Thompson, RL Nation, ...
The Journal of antibiotics 67 (2), 147-151, 2014
The major human and mouse granzymes are structurally and functionally divergent
D Kaiserman, CH Bird, J Sun, A Matthews, K Ung, JC Whisstock, ...
The Journal of cell biology 175 (4), 619-630, 2006
Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis
A Lourbakos, C Chinni, P Thompson, J Potempa, J Travis, EJ Mackie, ...
FEBS letters 435 (1), 45-48, 1998
Antimicrobial activity and toxicity of the major lipopeptide components of polymyxin B and colistin: last-line antibiotics against multidrug-resistant Gram-negative bacteria
KD Roberts, MAK Azad, J Wang, AS Horne, PE Thompson, RL Nation, ...
ACS infectious diseases 1 (11), 568-575, 2015
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases
DT Manallack, RA Hughes, PE Thompson
Journal of medicinal chemistry 48 (10), 3449-3462, 2005
The phytosulfokine (PSK) receptor is capable of guanylate cyclase activity and enabling cyclic GMP-dependent signaling in plants
L Kwezi, O Ruzvidzo, JI Wheeler, K Govender, S Iacuone, PE Thompson, ...
Journal of Biological Chemistry 286 (25), 22580-22588, 2011
The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism
D Wootten, CA Reynolds, KJ Smith, JC Mobarec, C Koole, EE Savage, ...
Cell 165 (7), 1632-1643, 2016
Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria
ZZ Deris, JD Swarbrick, KD Roberts, MAK Azad, J Akter, AS Horne, ...
Bioconjugate chemistry 25 (4), 750-760, 2014
Teaching ‘old’polymyxins new tricks: new-generation lipopeptides targeting gram-negative ‘superbugs’
T Velkov, KD Roberts, RL Nation, J Wang, PE Thompson, J Li
ACS chemical biology 9 (5), 1172-1177, 2014
Identification and development of specific inhibitors for insulin‐regulated aminopeptidase as a new class of cognitive enhancers
AL Albiston, S Diwakarla, RN Fernando, SJ Mountford, HR Yeatman, ...
British journal of pharmacology 164 (1), 37-47, 2011
Pharmacokinetics of four different brands of colistimethate and formed colistin in rats
H He, JC Li, RL Nation, J Jacob, G Chen, HJ Lee, BT Tsuji, PE Thompson, ...
Journal of Antimicrobial Chemotherapy 68 (10), 2311-2317, 2013
Importance of the P4′ residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop
J Sun, JC Whisstock, P Harriott, B Walker, A Novak, PE Thompson, ...
Journal of Biological Chemistry 276 (18), 15177-15184, 2001
Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites
BL Howard, KL Harvey, RJ Stewart, MF Azevedo, BS Crabb, IG Jennings, ...
ACS chemical biology 10 (4), 1145-1154, 2015
RhoA Sustains Integrin αIIbβ3Adhesion Contacts under High Shear
SM Schoenwaelder, SC Hughan, K Boniface, S Fernando, M Holdsworth, ...
Journal of Biological Chemistry 277 (17), 14738-14746, 2002
Inhibition of phosphoinositide 3-kinase β
SP Jackson, AD Robertson, V Kenche, P Thompson, H Prabaharan, ...
US Patent 7,598,377, 2009
Homoanatoxin: a potent analogue of anatoxin-a
S Wonnacott, KL Swanson, EX Albuquerque, NJS Huby, P Thompson, ...
Biochemical pharmacology 43 (3), 419-423, 1992
Polymyxins: a new hope in combating Gram-negative superbugs?
T Velkov, KD Roberts, PE Thompson, J Li
Future medicinal chemistry 8 (10), 1017-1025, 2016
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