| Tumor hypoxia: a target for selective cancer therapy S Kizaka‐Kondoh, M Inoue, H Harada, M Hiraoka Cancer science 94 (12), 1021-1028, 2003 | 433 | 2003 |
| HIF-1-dependent reprogramming of glucose metabolic pathway of cancer cells and its therapeutic significance A Nagao, M Kobayashi, S Koyasu, CCT Chow, H Harada International journal of molecular sciences 20 (2), 238, 2019 | 362 | 2019 |
| Synthesis and biological evaluation of indolyl chalcones as antitumor agents D Kumar, NM Kumar, K Akamatsu, E Kusaka, H Harada, T Ito Bioorganic & medicinal chemistry letters 20 (13), 3916-3919, 2010 | 303 | 2010 |
| How can we overcome tumor hypoxia in radiation therapy? H Harada Journal of radiation research 52 (5), 545-556, 2011 | 219 | 2011 |
| Regulatory mechanisms of hypoxia‐inducible factor 1 activity: two decades of knowledge S Koyasu, M Kobayashi, Y Goto, M Hiraoka, H Harada Cancer science 109 (3), 560-571, 2018 | 218 | 2018 |
| Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells H Harada, M Hiraoka, S Kizaka-Kondoh Cancer research 62 (7), 2013-2018, 2002 | 211 | 2002 |
| UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α Y Goto, L Zeng, CJ Yeom, Y Zhu, A Morinibu, K Shinomiya, M Kobayashi, ... Nature communications 6 (1), 6153, 2015 | 210 | 2015 |
| Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels H Harada, M Inoue, S Itasaka, K Hirota, A Morinibu, K Shinomiya, L Zeng, ... Nature communications 3 (1), 783, 2012 | 190 | 2012 |
| The Akt/mTOR pathway assures the synthesis of HIF-1α protein in a glucose-and reoxygenation-dependent manner in irradiated tumors H Harada, S Itasaka, S Kizaka-Kondoh, K Shibuya, A Morinibu, ... Journal of Biological Chemistry 284 (8), 5332-5342, 2009 | 186 | 2009 |
| Significance of HIF-1-active cells in angiogenesis and radioresistance H Harada, S Kizaka-Kondoh, G Li, S Itasaka, K Shibuya, M Inoue, ... Oncogene 26 (54), 7508-7516, 2007 | 172 | 2007 |
| Microenvironment and radiation therapy M Yoshimura, S Itasaka, H Harada, M Hiraoka BioMed research international 2013, 2013 | 162 | 2013 |
| HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs T Zhao, Y Zhu, A Morinibu, M Kobayashi, K Shinomiya, S Itasaka, ... Scientific reports 4 (1), 3793, 2014 | 133 | 2014 |
| Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals H Harada, S Kizaka-Kondoh, M Hiraoka Molecular imaging 4 (3), 15353500200505112, 2005 | 121 | 2005 |
| Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1α/OATPs signaling axis JB Wu, C Shao, X Li, C Shi, Q Li, P Hu, YT Chen, X Dou, D Sahu, W Li, ... Biomaterials 35 (28), 8175-8185, 2014 | 116 | 2014 |
| Hypoxia-inducible factor 1–mediated characteristic features of cancer cells for tumor radioresistance H Harada Journal of radiation research 57 (S1), i99-i105, 2016 | 115 | 2016 |
| The HIF-1-active microenvironment: an environmental target for cancer therapy S Kizaka-Kondoh, S Tanaka, H Harada, M Hiraoka Advanced drug delivery reviews 61 (7-8), 623-632, 2009 | 114 | 2009 |
| Space radiation biology for “Living in Space” S Furukawa, A Nagamatsu, M Nenoi, A Fujimori, S Kakinuma, T Katsube, ... BioMed Research International 2020, 2020 | 104 | 2020 |
| Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis L Zeng, A Morinibu, M Kobayashi, Y Zhu, X Wang, Y Goto, CJ Yeom, ... Oncogene 34 (36), 4758-4766, 2015 | 103 | 2015 |
| Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy H Harada, S Itasaka, Y Zhu, L Zeng, X Xie, A Morinibu, K Shinomiya, ... British journal of cancer 100 (5), 747-757, 2009 | 97 | 2009 |
| High‐Contrast Fluorescence Imaging of Tumors In Vivo Using Nanoparticles of Amphiphilic Brush‐Like Copolymers Produced by ROMP K Miki, A Kimura, K Oride, Y Kuramochi, H Matsuoka, H Harada, ... Angewandte Chemie International Edition 50 (29), 6567-6570, 2011 | 96 | 2011 |
