John D Lee
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The Concise Guide to PHARMACOLOGY 2019/20: G protein‐coupled receptors
SPH Alexander, A Christopoulos, AP Davenport, E Kelly, A Mathie, ...
British Journal of Pharmacology 176, S21-S141, 2019
Dysregulation of the complement cascade in the hSOD1G93Atransgenic mouse model of amyotrophic lateral sclerosis
JD Lee, NA Kamaruzaman, JNT Fung, SM Taylor, BJ Turner, JD Atkin, ...
Journal of neuroinflammation 10 (1), 119, 2013
Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions
FH Brennan, JD Lee, MJ Ruitenberg, TM Woodruff
Seminars in immunology 28 (3), 292-308, 2016
Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis
MJ Fogarty, PM Klenowski, JD Lee, JR Drieberg-Thompson, SE Bartlett, ...
Scientific reports 6, 37968, 2016
Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1 G93A mouse model of amyotrophic lateral sclerosis
JY Lee, JD Lee, S Phipps, PG Noakes, TM Woodruff
Journal of neuroinflammation 12 (1), 1-9, 2015
Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ
LG Coulthard, OA Hawksworth, R Li, A Balachandran, JD Lee, ...
Journal of Neuroscience 37 (22), 5395-5407, 2017
Pharmacological inhibition of complement C5a‐C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral …
JD Lee, V Kumar, JNT Fung, MJ Ruitenberg, PG Noakes, TM Woodruff
British journal of pharmacology 174 (8), 689-699, 2017
Role for terminal complement activation in amyotrophic lateral sclerosis disease progression
TM Woodruff, JD Lee, PG Noakes
Proceedings of the National Academy of Sciences 111 (1), E3-E4, 2014
Impairments to the GH-IGF-I Axis in hSOD1G93A Mice Give Insight into Possible Mechanisms of GH Dysregulation in Patients with Amyotrophic Lateral Sclerosis
FJ Steyn, ST Ngo, JD Lee, JW Leong, AJ Buckley, JD Veldhuis, ...
Endocrinology 153 (8), 3735-3746, 2012
Defects in synaptic transmission at the neuromuscular junction precede motor deficits in a TDP‐43Q331K transgenic mouse model of amyotrophic lateral sclerosis
KK Chand, KM Lee, JD Lee, H Qiu, EF Willis, NA Lavidis, MA Hilliard, ...
The FASEB Journal 32 (5), 2676-2689, 2018
Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis
HA Wang, JD Lee, KM Lee, TM Woodruff, PG Noakes
Skeletal muscle 7 (1), 10, 2017
Silencing of ghrelin receptor expression inhibits endometrial cancer cell growth in vitro and in vivo
JNT Fung, PL Jeffery, JD Lee, I Seim, D Roche, A Obermair, LK Chopin, ...
American Journal of Physiology-Endocrinology and Metabolism 305 (2), E305-E313, 2013
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins
V Deora, JD Lee, EA Albornoz, L McAlary, CJ Jagaraj, AAB Robertson, ...
Glia 68 (2), 407-421, 2020
Complement components are upregulated and correlate with disease progression in the TDP-43 Q331K mouse model of amyotrophic lateral sclerosis
JD Lee, SC Levin, EF Willis, R Li, TM Woodruff, PG Noakes
Journal of neuroinflammation 15 (1), 1-13, 2018
The complement receptor C5aR2: a powerful modulator of innate and adaptive immunity
XX Li, JD Lee, C Kemper, TM Woodruff
The Journal of Immunology 202 (12), 3339-3348, 2019
Gut microbiota in ALS: possible role in pathogenesis?
PA McCombe, RD Henderson, A Lee, JD Lee, TM Woodruff, R Restuadi, ...
Expert review of neurotherapeutics 19 (9), 785-805, 2019
John D. Lee1, Jia Y. Lee1, Stephen M. Taylor1
PG Noakes, TM Woodruff
Amyotrophic Lateral Sclerosis, 393, 2012
The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres
JW Crane, GP Baiquni, RKP Sullivan, JD Lee, P Sah, SM Taylor, ...
Journal of neuroinflammation 6 (1), 1-10, 2009
Revisiting the role of the innate immune complement system in ALS
SE Parker, AM Hanton, SN Stefanou, PG Noakes, TM Woodruff, JD Lee
Neurobiology of disease 127, 223-232, 2019
Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice
V Kumar, JD Lee, RJ Clark, TM Woodruff
Scientific reports 8 (1), 1-11, 2018
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Articles 1–20