|Functional significance of the perforin/granzyme cell death pathway|
JA Trapani, MJ Smyth
Nature Reviews Immunology 2 (10), 735-747, 2002
|Differential tumor surveillance by natural killer (NK) and NKT cells|
MJ Smyth, KYT Thia, SEA Street, E Cretney, JA Trapani, M Taniguchi, ...
The Journal of experimental medicine 191 (4), 661-668, 2000
|In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains|
T Fernandes-Alnemri, RC Armstrong, J Krebs, SM Srinivasula, L Wang, ...
Proceedings of the National Academy of Sciences 93 (15), 7464-7469, 1996
|A fresh look at tumor immunosurveillance and immunotherapy|
MJ Smyth, DI Godfrey, JA Trapani
Nature immunology 2 (4), 293-299, 2001
|Type I IFNs enhance the terminal differentiation of dendritic cells|
T Luft, KC Pang, E Thomas, P Hertzog, DNJ Hart, J Trapani, J Cebon
The Journal of Immunology 161 (4), 1947-1953, 1998
|Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma|
MJ Smyth, KYT Thia, SEA Street, D MacGregor, DI Godfrey, JA Trapani
The Journal of experimental medicine 192 (5), 755-760, 2000
|Perforin and granzymes: function, dysfunction and human pathology|
I Voskoboinik, JC Whisstock, JA Trapani
Nature Reviews Immunology 15 (6), 388-400, 2015
|Perforin-mediated target-cell death and immune homeostasis|
I Voskoboinik, MJ Smyth, JA Trapani
Nature Reviews Immunology 6 (12), 940-952, 2006
|Granzymes: exogenous porteinases that induce target cell apoptosis|
MJ Smyth, JA Trapani
Immunology today 16 (4), 202-206, 1995
|Suppression of lymphoma and epithelial malignancies effected by interferon γ|
SEA Street, JA Trapani, D MacGregor, MJ Smyth
The Journal of experimental medicine 196 (1), 129-134, 2002
|Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B–mediated caspase activation|
VR Sutton, JE Davis, M Cancilla, RW Johnstone, AA Ruefli, K Sedelies, ...
The Journal of experimental medicine 192 (10), 1403-1414, 2000
|The Ced-3/interleukin 1β converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2α are substrates for the apoptotic mediator CPP32|
SM Srinivasula, T Fernandes-Alnemri, J Zangrilli, N Robertson, ...
Journal of Biological Chemistry 271 (43), 27099-27106, 1996
|The structural basis for membrane binding and pore formation by lymphocyte perforin|
RHP Law, N Lukoyanova, I Voskoboinik, TT Caradoc-Davies, K Baran, ...
Nature 468 (7322), 447-451, 2010
|Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia|
DS Ritchie, PJ Neeson, A Khot, S Peinert, T Tai, K Tainton, K Chen, ...
Molecular Therapy 21 (11), 2122-2129, 2013
|CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity|
ML Burr, CE Sparbier, YC Chan, JC Williamson, K Woods, PA Beavis, ...
Nature 549 (7670), 101-105, 2017
|Discordant regulation of granzyme H and granzyme B expression in human lymphocytes|
KA Sedelies, TJ Sayers, KM Edwards, W Chen, DG Pellicci, DI Godfrey, ...
Journal of Biological Chemistry 279 (25), 26581-26587, 2004
|Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death …|
CH Bird, VR Sutton, J Sun, CE Hirst, A Novak, S Kumar, JA Trapani, ...
Molecular and cellular biology 18 (11), 6387-6398, 1998
|A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes|
J Sun, CH Bird, V Sutton, L McDonald, PB Coughlin, TA De Jong, ...
Journal of Biological Chemistry 271 (44), 27802-27809, 1996
|Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation|
SS Metkar, B Wang, M Aguilar-Santelises, SM Raja, L Uhlin-Hansen, ...
Immunity 16 (3), 417-428, 2002
|Novel mechanisms of apoptosis induced by histone deacetylase inhibitors|
MJ Peart, KM Tainton, AA Ruefli, AE Dear, KA Sedelies, LA O’Reilly, ...
Cancer research 63 (15), 4460-4471, 2003