| Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense EM Leslie, RG Deeley, SPC Cole Toxicology and applied pharmacology 204 (3), 216-237, 2005 | 1750 | 2005 |
| Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters EM Leslie, RG Deeley, SPC Cole Toxicology 167 (1), 3-23, 2001 | 477 | 2001 |
| Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1): evidence that a tri-glutathione conjugate is required EM Leslie, A Haimeur, MP Waalkes Journal of Biological Chemistry 279 (31), 32700-32708, 2004 | 311 | 2004 |
| Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and ATPase activities by interaction with dietary flavonoids EM Leslie, Q Mao, CJ Oleschuk, RG Deeley, SPC Cole Molecular Pharmacology 59 (5), 1171-1180, 2001 | 309 | 2001 |
| Membrane topology of the multidrug resistance protein (MRP): a study of glycosylation-site mutants reveals an extracytosolic NH2 terminus DR Hipfner, KC Almquist, EM Leslie, JH Gerlach, CE Grant, RG Deeley, ... Journal of Biological Chemistry 272 (38), 23623-23630, 1997 | 275 | 1997 |
| CFTR directly mediates nucleotide-regulated glutathione flux I Kogan, M Ramjeesingh, C Li, JF Kidd, Y Wang, EM Leslie, SPC Cole, ... The EMBO journal 22 (9), 1981-1989, 2003 | 268 | 2003 |
| Transport of the β-O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1 … EM Leslie, K Ito, P Upadhyaya, SS Hecht, RG Deeley, SPC Cole Journal of Biological Chemistry 276 (30), 27846-27854, 2001 | 199 | 2001 |
| Methods to evaluate biliary excretion of drugs in humans: an updated review G Ghibellini, EM Leslie, KLR Brouwer Molecular pharmaceutics 3 (3), 198-211, 2006 | 192 | 2006 |
| Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1) EM Leslie, RG Deeley, SPC Cole Drug metabolism and disposition 31 (1), 11-15, 2003 | 160 | 2003 |
| Arsenic–glutathione conjugate transport by the human multidrug resistance proteins (MRPs/ABCCs) EM Leslie Journal of inorganic biochemistry 108, 141-149, 2012 | 156 | 2012 |
| Comparative toxicity of arsenic metabolites in human bladder cancer EJ-1 cells H Naranmandura, MW Carew, S Xu, J Lee, EM Leslie, M Weinfeld, XC Le Chemical research in toxicology 24 (9), 1586-1596, 2011 | 147 | 2011 |
| Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1) by bosentan: a mechanism for species differences in hepatotoxicity EM Leslie, PB Watkins, RB Kim, KLR Brouwer Journal of Pharmacology and Experimental Therapeutics 321 (3), 1170-1178, 2007 | 145 | 2007 |
| A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance S Conrad, HM Kauffmann, K Ito, EM Leslie, RG Deeley, D Schrenk, ... Pharmacogenetics and Genomics 12 (4), 321-330, 2002 | 140 | 2002 |
| In Vitro–In Vivo Correlation of Hepatobiliary Drug Clearance in Humans G Ghibellini, LS Vasist, EM Leslie, WD Heizer, RJ Kowalsky, BF Calvo, ... Clinical Pharmacology & Therapeutics 81 (3), 406-413, 2007 | 133 | 2007 |
| ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells Q Mao, EM Leslie, RG Deeley, SPC Cole Biochimica et Biophysica Acta (BBA)-Biomembranes 1461 (1), 69-82, 1999 | 116 | 1999 |
| Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity TL Marion, EM Leslie, KLR Brouwer Molecular pharmaceutics 4 (6), 911-918, 2007 | 109 | 2007 |
| Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies G Ghibellini, EM Leslie, GM Pollack, KLR Brouwer Pharmaceutical research 25, 1851-1860, 2008 | 102 | 2008 |
| Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation J Liu, C Li, W Qu, E Leslie, CL Bonifant, GS Buzard, JE Saavedra, ... Molecular cancer therapeutics 3 (6), 709-714, 2004 | 95 | 2004 |
| Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug resistance protein 1 (MRP1/ABCC1) EM Leslie, IJ Létourneau, RG Deeley, SPC Cole Biochemistry 42 (18), 5214-5224, 2003 | 91 | 2003 |
| Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP: localization of their epitopes to the nucleotide-binding domains of … DR Hipfner, Q Mao, W Qiu, EM Leslie, M Gao, RG Deeley, SPC Cole Journal of Biological Chemistry 274 (22), 15420-15426, 1999 | 90 | 1999 |
Susan PC ColeDistinguished University Professor, Bracken Chair in Genetics & Molecular Medicine, Cancer BiologyVerified email at queensu.ca
