Cheng Chang
Cheng Chang
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Rapid identification of P-glycoprotein substrates and inhibitors
C Chang, PM Bahadduri, JE Polli, PW Swaan, S Ekins
Drug metabolism and disposition 34 (12), 1976-1984, 2006
Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites
S Ekins, C Chang, S Mani, MD Krasowski, EJ Reschly, M Iyer, ...
Molecular pharmacology 72 (3), 592-603, 2007
Structural determinants of P-glycoprotein-mediated transport of glucocorticoids
CR Yates, C Chang, JD Kearbey, K Yasuda, EG Schuetz, DD Miller, ...
Pharmaceutical research 20 (11), 1794-1803, 2003
Pharmacophore-based discovery of ligands for drug transporters
C Chang, S Ekins, P Bahadduri, PW Swaan
Advanced drug delivery reviews 58 (12), 1431-1450, 2006
Molecular determinants of substrate/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2
WM Suhre, S Ekins, C Chang, PW Swaan, SH Wright
Molecular pharmacology 67 (4), 1067-1077, 2005
A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor
CE Bohl, C Chang, ML Mohler, J Chen, DD Miller, PW Swaan, JT Dalton
Journal of medicinal chemistry 47 (15), 3765-3776, 2004
Comparative pharmacophore modeling of organic anion transporting polypeptides: a meta-analysis of rat Oatp1a1 and human OATP1B1
C Chang, KS Pang, PW Swaan, S Ekins
Journal of Pharmacology and Experimental Therapeutics 314 (2), 533-541, 2005
Computational approaches to modeling drug transporters
C Chang, PW Swaan
European Journal of Pharmaceutical Sciences 27 (5), 411-424, 2006
Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1
C Chang, PW Swaan, LY Ngo, PY Lum, SD Patil, JD Unadkat
Molecular pharmacology 65 (3), 558-570, 2004
Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2)
EY Zhang, MA Phelps, A Banerjee, CM Khantwal, C Chang, F Helsper, ...
Biochemistry 43 (36), 11380-11392, 2004
In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors
S Ekins, JS Johnston, P Bahadduri, VM D’Souza, A Ray, C Chang, ...
Pharmaceutical research 22 (4), 512-517, 2005
Computational models to assign biopharmaceutics drug disposition classification from molecular structure
A Khandelwal, PM Bahadduri, C Chang, JE Polli, PW Swaan, S Ekins
Pharmaceutical research 24 (12), 2249-2262, 2007
In vitro–in vivo correlation for low-clearance compounds using hepatocyte relay method
L Di, K Atkinson, CC Orozco, C Funk, H Zhang, TS McDonald, B Tan, J Lin, ...
Drug Metabolism and Disposition 41 (12), 2018-2023, 2013
Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3)
H Hu, CJ Endres, C Chang, NS Umapathy, EW Lee, YJ Fei, S Itagaki, ...
Molecular pharmacology 69 (5), 1542-1553, 2006
Plasma Protein Binding of Challenging Compounds
K Riccardi, S Cawley, PD Yates, C Chang, C Funk, M Niosi, J Lin, L Di
Journal of pharmaceutical sciences 104 (8), 2627-2636, 2015
Modeling and validating chronic pharmacological manipulation of circadian rhythms
JK Kim, DB Forger, M Marconi, D Wood, A Doran, T Wager, C Chang, ...
CPT: pharmacometrics & systems pharmacology 2 (7), 1-11, 2013
Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2)
A Banerjee, A Ray, C Chang, PW Swaan
Biochemistry 44 (24), 8908-8917, 2005
Application of data mining approaches to drug delivery
S Ekins, J Shimada, C Chang
Advanced drug delivery reviews 58 (12), 1409-1430, 2006
In silico strategies for modeling membrane transporter function
C Chang, A Ray, P Swaan
Drug discovery today 10 (9), 663-671, 2005
Quantitative PK–PD model-based translational pharmacology of a novel kappa opioid receptor antagonist between rats and humans
C Chang, W Byon, Y Lu, LK Jacobsen, LL Badura, A Sawant-Basak, ...
The AAPS journal 13 (4), 565-575, 2011
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