| DNA interstrand crosslink repair and cancer AJ Deans, SC West Nature reviews cancer 11 (7), 467-480, 2011 | 1150 | 2011 |
| Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2 C MacKay, AC Déclais, C Lundin, A Agostinho, AJ Deans, TJ MacArtney, ... Cell 142 (1), 65-76, 2010 | 355 | 2010 |
| The Fanconi anemia pathway maintains genome stability by coordinating replication and transcription RA Schwab, J Nieminuszczy, F Shah, J Langton, DL Martinez, CC Liang, ... Molecular cell 60 (3), 351-361, 2015 | 337 | 2015 |
| FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia AJ Deans, SC West Molecular cell 36 (6), 943-953, 2009 | 296 | 2009 |
| Increased platelet activation in patients with stable and acute exacerbation of COPD JD Maclay, DA McAllister, S Johnston, J Raftis, C McGuinnes, A Deans, ... Thorax 66 (9), 769-774, 2011 | 256 | 2011 |
| The Fanconi Anemia DNA Repair Pathway: Structural and Functional Insights into a Complex Disorder H Walden, AJ Deans Annual Review of Biophysics 43 (1), 2014 | 253 | 2014 |
| FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex SJ Collis, A Ciccia, AJ Deans, Z Hořejší, JS Martin, SL Maslen, JM Skehel, ... Molecular cell 32 (3), 313-324, 2008 | 243 | 2008 |
| BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage M Fabbro, K Savage, K Hobson, AJ Deans, SN Powell, GA McArthur, ... Journal of Biological Chemistry 279 (30), 31251-31258, 2004 | 209 | 2004 |
| The architecture and evolution of cancer neochromosomes DW Garsed, OJ Marshall, VDA Corbin, A Hsu, L Di Stefano, J Schröder, ... Cancer cell 26 (5), 653-667, 2014 | 180 | 2014 |
| FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops B Silva, R Pentz, AM Figueira, R Arora, YW Lee, C Hodson, ... Nature communications 10 (1), 2253, 2019 | 150 | 2019 |
| The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT) R Lu, JJ O’Rourke, AP Sobinoff, JAM Allen, CB Nelson, CG Tomlinson, ... Nature communications 10 (1), 2252, 2019 | 134 | 2019 |
| Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers AJ Deans, KK Khanna, CJ McNees, C Mercurio, J Heierhorst, ... Cancer research 66 (16), 8219-8226, 2006 | 131 | 2006 |
| Mechanism of ubiquitination and deubiquitination in the Fanconi anemia pathway S van Twest, VJ Murphy, C Hodson, W Tan, P Swuec, JJ O’Rourke, ... Molecular cell 65 (2), 247-259, 2017 | 124 | 2017 |
| CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer E Sanij, KM Hannan, J Xuan, S Yan, JE Ahern, AS Trigos, N Brajanovski, ... Nature communications 11 (1), 2641, 2020 | 103 | 2020 |
| The DNA translocase activity of FANCM protects stalled replication forks AN Blackford, RA Schwab, J Nieminuszczy, AJ Deans, SC West, ... Human molecular genetics 21 (9), 2005-2016, 2012 | 81 | 2012 |
| Neuromuscular electrical stimulation prevents muscle function deterioration in exacerbated COPD: a pilot study S Giavedoni, A Deans, P McCaughey, E Drost, W MacNee, ... Respiratory medicine 106 (10), 1429-1434, 2012 | 79 | 2012 |
| MAD1 and p27KIP1 Cooperate To Promote Terminal Differentiation of Granulocytes and To Inhibit Myc Expression and Cyclin E-CDK2 Activity GA McArthur, KP Foley, ML Fero, CR Walkley, AJ Deans, JM Roberts, ... Molecular and cellular biology 22 (9), 3014-3023, 2002 | 69 | 2002 |
| The FA core complex contains a homo-dimeric catalytic module for the symmetric mono-ubiquitination of FANCI-FANCD2 P Swuec, L Renault, A Borg, F Shah, VJ Murphy, S van Twest, ... Cell reports 18 (3), 611-623, 2017 | 64 | 2017 |
| Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1 CE Caldon, CM Sergio, A Burgess, AJ Deans, RL Sutherland, ... Cell cycle 12 (4), 606-617, 2013 | 63 | 2013 |
| Monoubiquitination by the human Fanconi anemia core complex clamps FANCI: FANCD2 on DNA in filamentous arrays W Tan, S van Twest, A Leis, R Bythell-Douglas, VJ Murphy, M Sharp, ... elife 9, e54128, 2020 | 58 | 2020 |
Stephen WestFrancis Crick InstituteVerified email at crick.ac.uk
