Follow
Nils Pemberton
Nils Pemberton
Medicinal Chemistry, RIA iMed, AstraZeneca
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria
JS Pinkner, H Remaut, F Buelens, E Miller, V Åberg, N Pemberton, ...
Proceedings of the National Academy of Sciences 103 (47), 17897-17902, 2006
3652006
Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation
M Friden-Saxin, N Pemberton, K da Silva Andersson, C Dyrager, ...
The Journal of Organic Chemistry 74 (7), 2755-2759, 2009
652009
Synthesis of multi ring-fused 2-pyridones via an acyl-ketene imine cyclocondensation
N Pemberton, L Jakobsson, F Almqvist
Organic Letters 8 (5), 935-938, 2006
582006
Synthesis and functionalization of cyclic sulfonimidamides: a novel chiral heterocyclic carboxylic acid bioisostere
N Pemberton, H Graden, E Evertsson, E Bratt, M Lepistö, ...
ACS Medicinal Chemistry Letters 3 (7), 574-578, 2012
562012
Microwave-assisted synthesis of highly substituted aminomethylated 2-pyridones
N Pemberton, V Åberg, H Almstedt, A Westermark, F Almqvist
The Journal of organic chemistry 69 (23), 7830-7835, 2004
562004
A class of highly selective inhibitors bind to an active state of PI3Kγ
G Gangadhara, G Dahl, T Bohnacker, R Rae, J Gunnarsson, S Blaho, ...
Nature chemical biology 15 (4), 348-357, 2019
452019
Discovery of highly isoform selective orally bioavailable phosphoinositide 3-kinase (PI3K)-γ inhibitors
N Pemberton, M Mogemark, S Arlbrandt, P Bold, RJ Cox, C Gardelli, ...
Journal of Medicinal Chemistry 61 (12), 5435-5441, 2018
432018
KHMDS Enhanced SmI2-Mediated Reformatsky Type α-Cyanation
T Ankner, M Friden-Saxin, N Pemberton, T Seifert, M Grøtli, K Luthman, ...
Organic Letters 12 (10), 2210-2213, 2010
422010
Functionalization of bicyclic 2-pyridones targeting pilus biogenesis in uropathogenic Escherichia coli
N Pemberton, JS Pinkner, JM Jones, L Jakobsson, SJ Hultgren, ...
Tetrahedron letters 48 (26), 4543-4546, 2007
312007
NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly
M Hedenström, H Emtenäs, N Pemberton, V Åberg, SJ Hultgren, ...
Organic & biomolecular chemistry 3 (23), 4193-4200, 2005
292005
Synthesis and evaluation of dihydroimidazolo and dihydrooxazolo ring-fused 2-pyridones—targeting pilus biogenesis in uropathogenic bacteria
N Pemberton, JS Pinkner, S Edvinsson, SJ Hultgren, F Almqvist
Tetrahedron 64 (40), 9368-9376, 2008
272008
Cycloaddition of Δ2-Thiazolines and Acyl Ketenes under Acidic Conditions Results in Bicyclic 1,3-Oxazinones and Not 6-Acylpenams as Earlier Reported
N Pemberton, H Emtenäs, D Boström, PJ Domaille, WA Greenberg, ...
Organic Letters 7 (6), 1019-1021, 2005
272005
Design and synthesis of soluble and cell-permeable PI3Kδ inhibitors for long-acting inhaled administration
MWD Perry, K Björhall, B Bonn, J Carlsson, Y Chen, A Eriksson, ...
Journal of Medicinal Chemistry 60 (12), 5057-5071, 2017
242017
Discovery of AZD8154, a dual PI3Kγδ inhibitor for the treatment of asthma
MWD Perry, K Bjorhall, P Bold, M Brulls, U Borjesson, J Carlsson, ...
Journal of Medicinal Chemistry 64 (12), 8053-8075, 2021
232021
Chroman-4-one and chromone based somatostatin β-turn mimetics
M Friden-Saxin, T Seifert, M Malo, K da Silva Andersson, N Pemberton, ...
European Journal of Medicinal Chemistry 114, 59-64, 2016
162016
Enantiomeric purity determination by NMR: proving the purity of a single enantiomer
RJ Lewis, MA Bernstein, HF Chang, D Chapman, N Pemberton
Tetrahedron: Asymmetry 24 (13-14), 866-870, 2013
112013
Microwave-assisted synthesis and functionalization of 2-pyridones, 2-quinolones and other ring-fused 2-pyridones
N Pemberton, E Chorell, F Almqvist
Microwave-Assisted Synthesis of Heterocycles, 1-30, 2006
92006
Using Macrocyclic G‐Quadruplex Ligands to Decipher the Interactions Between Small Molecules and G‐Quadruplex DNA
M Andréasson, N Bhuma, N Pemberton, E Chorell
Chemistry–A European Journal 28 (65), e202202020, 2022
52022
Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1, 3, 4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism
L Ripa, J Sandmark, G Hughes, I Shamovsky, A Gunnarsson, ...
Journal of Medicinal Chemistry 66 (20), 14188-14207, 2023
32023
Amino methylated 2-pyridinones
SJ Hultgren, JS Pinkner, F Almqvist, N Pemberton, V Aberg, A Larsson
US Patent 7,411,066, 2008
32008
The system can't perform the operation now. Try again later.
Articles 1–20