Yanni Ka-Yan Chin
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Structural basis for the modulation of voltage-gated sodium channels by animal toxins
H Shen, Z Li, Y Jiang, X Pan, J Wu, B Cristofori-Armstrong, JJ Smith, ...
Science 362 (6412), eaau2596, 2018
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a
IR Chassagnon, CA McCarthy, YKY Chin, SS Pineda, A Keramidas, ...
Proceedings of the National Academy of Sciences 114 (14), 3750-3755, 2017
Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities
M Chandra, YKY Chin, C Mas, JR Feathers, B Paul, S Datta, KE Chen, ...
Nature communications 10 (1), 1-14, 2019
The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes
JJ Paxman, NA Borg, J Horne, PE Thompson, Y Chin, P Sharma, ...
Journal of biological chemistry 284 (26), 17835-17845, 2009
Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene
SS Pineda, YKY Chin, EAB Undheim, S Senff, M Mobli, C Dauly, ...
Proceedings of the National Academy of Sciences 117 (21), 11399-11408, 2020
Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target NaV1. 7
JK Klint, YKY Chin, M Mobli
Molecular Pharmacology 88 (6), 1002-1010, 2015
PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold
B Madio, S Peigneur, YKY Chin, BR Hamilton, ST Henriques, JJ Smith, ...
Cellular and molecular life sciences 75 (24), 4511-4524, 2018
The structure of integrin α1I domain in complex with a collagen-mimetic peptide
YKY Chin, SJ Headey, B Mohanty, R Patil, PA McEwan, JD Swarbrick, ...
Journal of Biological Chemistry 288 (52), 36796-36809, 2013
Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis
JP Vivian, J Scoullar, AL Robertson, SP Bottomley, J Horne, Y Chin, ...
Journal of biological chemistry 283 (47), 32452-32461, 2008
Probing the Flexibility of the DsbA Oxidoreductase from Vibrio cholerae—a 15N-1H Heteronuclear NMR Relaxation Analysis of Oxidized and Reduced Forms of DsbA
J Horne, EJ d’Auvergne, M Coles, T Velkov, Y Chin, WN Charman, ...
Journal of molecular biology 371 (3), 703-716, 2007
Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus
A Touchard, A Brust, FC Cardoso, YKY Chin, V Herzig, AH Jin, A Dejean, ...
Biochimica et Biophysica Acta (BBA)-General Subjects 1860 (11), 2553-2562, 2016
A selective NaV1. 1 activator with potential for treatment of Dravet syndrome epilepsy
CY Chow, YKY Chin, L Ma, EAB Undheim, V Herzig, GF King
Biochemical Pharmacology 181, 113991, 2020
The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity
JS Wingerd, CA Mozar, CA Ussing, SS Murali, YKY Chin, ...
Scientific reports 7 (1), 1-15, 2017
Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target
L Ma, YKY Chin, Z Dekan, V Herzig, CY Chow, J Heighway, SW Lam, ...
Biochemical Pharmacology 158, 60-72, 2018
Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel NaV1.1 Provide Novel Leads for Development of Antiepileptic Drugs
CY Chow, YKY Chin, AA Walker, S Guo, LV Blomster, MJ Ward, V Herzig, ...
ACS pharmacology & translational science 3 (1), 119-134, 2019
Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom
K Luna-Ramirez, A Csoti, JR McArthur, YKY Chin, R Anangi, ...
Biochemical Pharmacology 174, 113782, 2020
Evaluation of chemical strategies for improving the stability and oral toxicity of insecticidal peptides
V Herzig, AD De Araujo, KP Greenwood, YKY Chin, MJ Windley, Y Chong, ...
Biomedicines 6 (3), 90, 2018
Assignments of human integrin α1I domain in the apo and Mg2+ bound states
YKY Chin, S Headey, B Mohanty, J Emsley, JS Simpson, MJ Scanlon
Biomolecular NMR assignments 8 (1), 117-121, 2014
A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals
DA Eagles, NJ Saez, B Krishnarjuna, JJ Bradford, YKY Chin, H Starobova, ...
Proceedings of the National Academy of Sciences 119 (7), e2112630119, 2022
The unusual conformation of cross‐strand disulfide bonds is critical to the stability of β‐hairpin peptides
E Deplazes, YKY Chin, GF King, RL Mancera
Proteins: Structure, Function, and Bioinformatics 88 (3), 485-502, 2020
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Articles 1–20