Karen Sheppard
Karen Sheppard
Peter MacCallum Cancer Centre
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The cell-cycle regulator CDK4: an emerging therapeutic target in melanoma
KE Sheppard, GA McArthur
Clinical Cancer Research 19 (19), 5320-5328, 2013
Targeting PI3 kinase/AKT/mTOR signaling in cancer
K Sheppard, KM Kinross, B Solomon, RB Pearson, WA Phillips
Critical Reviews™ in Oncogenesis 17 (1), 2012
Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of GlycolysisRole of Glycolysis in Responses to BRAF Inhibition
TJ Parmenter, M Kleinschmidt, KM Kinross, ST Bond, J Li, MR Kaadige, ...
Cancer discovery 4 (4), 423-433, 2014
An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice
KM Kinross, KG Montgomery, M Kleinschmidt, P Waring, I Ivetac, A Tikoo, ...
The Journal of clinical investigation 122 (2), 553-557, 2012
Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers
Ĺ Helland, MS Anglesio, J George, PA Cowin, CN Johnstone, CM House, ...
PloS one 6 (4), e18064, 2011
Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell …
RJ Young, K Waldeck, C Martin, JH Foo, DP Cameron, L Kirby, H Do, ...
Pigment cell & melanoma research 27 (4), 590-600, 2014
Adrenocortical steroids and the brain
JW Funder, K Sheppard
Annual review of Physiology 49 (1), 397-411, 1987
The type I and type II 11β-hydroxysteroid dehydrogenase enzymes
Z Krozowski, KXZ Li, K Koyama, RE Smith, VR Obeyesekere, ...
The Journal of steroid biochemistry and molecular biology 69 (1-6), 391-401, 1999
Second AKT: the rise of SGK in cancer signalling
MA Bruhn, RB Pearson, RD Hannan, KE Sheppard
Growth factors 28 (6), 394-408, 2010
AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer
JC Chan, KM Hannan, K Riddell, PY Ng, A Peck, RS Lee, S Hung, ...
Science signaling 4 (188), ra56-ra56, 2011
AKT-independent PI3-K signaling in cancer–emerging role for SGK3
MA Bruhn, RB Pearson, RD Hannan, KE Sheppard
Cancer management and research 5, 281, 2013
The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma
R Ramsdale, RN Jorissen, FZ Li, S Al-Obaidi, T Ward, KE Sheppard, ...
Science signaling 8 (390), ra82-ra82, 2015
Regression of pressure overload-induced left ventricular hypertrophy in mice
XM Gao, H Kiriazis, XL Moore, XH Feng, K Sheppard, A Dart, XJ Du
American Journal of Physiology-Heart and Circulatory Physiology 288 (6 …, 2005
First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation StudyFirst-in-human Study of …
A Khot, N Brajanovski, DP Cameron, N Hein, KH Maclachlan, E Sanij, ...
Cancer discovery 9 (8), 1036-1049, 2019
LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin
PA Cowin, J George, S Fereday, E Loehrer, P Van Loo, C Cullinane, ...
Cancer research 72 (16), 4060-4073, 2012
11β-Hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart
KE Sheppard, DJ Autelitano
Endocrinology 143 (1), 198-204, 2002
Mineralocorticoid specificity of renal type I receptors: in vivo binding studies
K Sheppard, JW Funder
American Journal of Physiology-Endocrinology And Metabolism 252 (2), E224-E229, 1987
Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors
KE Sheppard, C Cullinane, KM Hannan, M Wall, J Chan, F Barber, J Foo, ...
European journal of cancer 49 (18), 3936-3944, 2013
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
J Quin, KT Chan, JR Devlin, DP Cameron, J Diesch, C Cullinane, J Ahern, ...
Oncotarget 7 (31), 49800, 2016
Equivalent affinity of aldosterone and corticosterone for type I receptors in kidney and hippocampus: direct binding studies
KE Sheppard, JW Funder
Journal of steroid biochemistry 28 (6), 737-742, 1987
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