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John Gilchrist
John Gilchrist
Latigo Biotherapeutics
Verified email at latigobio.com
Title
Cited by
Cited by
Year
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
JD Osteen, V Herzig, J Gilchrist, JJ Emrick, C Zhang, X Wang, J Castro, ...
Nature 534 (7608), 494-499, 2016
2762016
Crystallographic insights into sodium-channel modulation by the β4 subunit
J Gilchrist, S Das, F Van Petegem, F Bosmans
Proceedings of the National Academy of Sciences 110 (51), E5016-E5024, 2013
1032013
The sixth transmembrane segment is a major gating component of the TMEM16A calcium-activated chloride channel
CJ Peters, JM Gilchrist, J Tien, NP Bethel, L Qi, T Chen, L Wang, YN Jan, ...
Neuron 97 (5), 1063-1077. e4, 2018
772018
A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a
NS Bende, S Dziemborowicz, M Mobli, V Herzig, J Gilchrist, J Wagner, ...
Nature communications 5 (1), 4350, 2014
752014
Animal toxins influence voltage-gated sodium channel function
J Gilchrist, BM Olivera, F Bosmans
Voltage Gated Sodium Channels, 203-229, 2014
742014
TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis
D Crottès, YHT Lin, CJ Peters, JM Gilchrist, AP Wiita, YN Jan, LY Jan
Proceedings of the National Academy of Sciences 116 (26), 13026-13035, 2019
582019
Nav1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents
J Gilchrist, S Dutton, M Diaz-Bustamante, A McPherson, N Olivares, ...
ACS chemical biology 9 (5), 1204-1212, 2014
502014
Binary architecture of the Nav1.2-β2 signaling complex
S Das, J Gilchrist, F Bosmans, F Van Petegem
Elife 5, e10960, 2016
492016
NaV1. 1 inhibition can reduce visceral hypersensitivity
J Salvatierra, J Castro, A Erickson, Q Li, J Braz, J Gilchrist, L Grundy, ...
JCI insight 3 (11), 2018
412018
Animal toxins can alter the function of Nav1. 8 and Nav1. 9
J Gilchrist, F Bosmans
Toxins 4 (8), 620-632, 2012
382012
Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami
V Herzig, M Ikonomopoulou, JJ Smith, S Dziemborowicz, J Gilchrist, ...
Scientific reports 6 (1), 29538, 2016
292016
The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity
JS Wingerd, CA Mozar, CA Ussing, SS Murali, YKY Chin, ...
Scientific reports 7 (1), 974, 2017
202017
Flexible low-cost system for small animal aerosol inhalation exposure to drugs, proteins, inflammatory agents, and infectious agents
WG Schroeder, LM Mitrescu, ML Hart, R Unnithan, JM Gilchrist, EE Smith, ...
BioTechniques 46 (3), 2009
192009
Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix
MP Ikonomopoulou, JJ Smith, V Herzig, SS Pineda, S Dziemborowicz, ...
Toxicon 123, 62-70, 2016
152016
Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry
MA Early, M Lishnevsky, JM Gilchrist, DM Higgins, IM Orme, WA Muller, ...
Experimental and molecular pathology 87 (2), 152-158, 2009
152009
Using voltage‐sensor toxins and their molecular targets to investigate NaV1.8 gating
J Gilchrist, F Bosmans
The Journal of Physiology 596 (10), 1863-1872, 2018
142018
Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice
M Lishnevsky, LC Young, SJ Woods, SD Groshong, RJ Basaraba, ...
Experimental and molecular pathology 97 (1), 128-136, 2014
112014
Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1. 7
DB Rupasinghe, V Herzig, I Vetter, Z Dekan, J Gilchrist, F Bosmans, ...
Biochemical pharmacology 181, 114080, 2020
82020
Differential effect of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) on leukocyte infiltration during contact hypersensitivity responses
M Early, WG Schroeder, R Unnithan, JM Gilchrist, WA Muller, A Schenkel
PeerJ 5, e3555, 2017
52017
Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1. 8 with a Unique Mechanism of Action
JM Gilchrist, ND Yang, V Jiang, BD Moyer
Molecular Pharmacology 105 (3), 233-249, 2024
2024
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