Keith Stubbs
Keith Stubbs
Associate Professor, University of Western Australia
Verified email at uwa.edu.au - Homepage
Title
Cited by
Cited by
Year
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
SA Yuzwa, MS Macauley, JE Heinonen, X Shan, RJ Dennis, Y He, ...
Nature chemical biology 4 (8), 483-490, 2008
5382008
Perturbation of indole-3-butyric acid homeostasis by the UDP-glucosyltransferase UGT74E2 modulates Arabidopsis architecture and water stress tolerance
VB Tognetti, O Van Aken, K Morreel, K Vandenbroucke, B Van De Cotte, ...
The Plant Cell 22 (8), 2660-2679, 2010
3052010
Structure and mechanism of a bacterial β-glucosaminidase having O-GlcNAcase activity
RJ Dennis, EJ Taylor, MS Macauley, KA Stubbs, JP Turkenburg, SJ Hart, ...
Nature structural & molecular biology 13 (4), 365-371, 2006
2022006
Analysis of PUGNAc and NAG-thiazoline as Transition State Analogues for Human O-GlcNAcase:  Mechanistic and Structural Insights into Inhibitor Selectivity and …
GE Whitworth, MS Macauley, KA Stubbs, RJ Dennis, EJ Taylor, GJ Davies, ...
Journal of the American Chemical Society 129 (3), 635-644, 2007
1562007
Identification of Asp174 and Asp175 as the Key Catalytic Residues of Human O-GlcNAcase by Functional Analysis of Site-Directed Mutants
N Çetinbaş, MS Macauley, KA Stubbs, R Drapala, DJ Vocadlo
Biochemistry 45 (11), 3835-3844, 2006
1152006
Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated β-lactam resistance
KA Stubbs, M Balcewich, BL Mark, DJ Vocadlo
Journal of Biological Chemistry 282 (29), 21382-21391, 2007
1142007
Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB
E Ficko-Blean, KA Stubbs, O Nemirovsky, DJ Vocadlo, AB Boraston
Proceedings of the National Academy of Sciences 105 (18), 6560-6565, 2008
982008
O-GlcNAcase Catalyzes Cleavage of Thioglycosides without General Acid Catalysis
MS Macauley, KA Stubbs, DJ Vocadlo
Journal of the American Chemical Society 127 (49), 17202-17203, 2005
842005
Synthesis and Use of Mechanism-Based Protein-Profiling Probes for Retaining β-d-Glucosaminidases Facilitate Identification of Pseudomonas aeruginosa NagZ
KA Stubbs, A Scaffidi, AW Debowski, BL Mark, RV Stick, DJ Vocadlo
Journal of the American Chemical Society 130 (1), 327-335, 2008
832008
The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin
C Wanty, A Anandan, S Piek, J Walshe, J Ganguly, RW Carlson, ...
Journal of molecular biology 425 (18), 3389-3402, 2013
772013
Visualizing the reaction coordinate of an O-GlcNAc hydrolase
Y He, MS Macauley, KA Stubbs, DJ Vocadlo, GJ Davies
Journal of the American Chemical Society 132 (6), 1807-1809, 2010
762010
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes
MS Macauley, Y He, TM Gloster, KA Stubbs, GJ Davies, DJ Vocadlo
Chemistry & biology 17 (9), 937-948, 2010
752010
Optimising a vortex fluidic device for controlling chemical reactivity and selectivity
L Yasmin, X Chen, KA Stubbs, CL Raston
Scientific reports 3, 2282, 2013
702013
A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase
KA Stubbs, N Zhang, DJ Vocadlo
Organic & Biomolecular Chemistry 4 (5), 839-845, 2006
702006
Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal β-lactam resistance in Pseudomonas aeruginosa
A Asgarali, KA Stubbs, A Oliver, DJ Vocadlo, BL Mark
Antimicrobial agents and chemotherapy 53 (6), 2274-2282, 2009
642009
Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding
A Anandan, GL Evans, K Condic-Jurkic, ML O’Mara, CM John, NJ Phillips, ...
Proceedings of the National Academy of Sciences 114 (9), 2218-2223, 2017
602017
Active site plasticity within the glycoside hydrolase NagZ underlies a dynamic mechanism of substrate distortion
JP Bacik, GE Whitworth, KA Stubbs, DJ Vocadlo, BL Mark
Chemistry & biology 19 (11), 1471-1482, 2012
602012
Insight into a strategy for attenuating AmpC‐mediated β‐lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ
MD Balcewich, KA Stubbs, Y He, TW James, GJ Davies, DJ Vocadlo, ...
Protein Science 18 (7), 1541-1551, 2009
432009
Vortex fluidic chemical transformations
J Britton, KA Stubbs, GA Weiss, CL Raston
Chemistry (Weinheim an der Bergstrasse, Germany) 23 (54), 13270, 2017
422017
Photoredox catalysis under shear using thin film vortex microfluidics
MN Gandy, CL Raston, KA Stubbs
Chemical Communications 51 (55), 11041-11044, 2015
402015
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