Keith Stubbs
Keith Stubbs
Associate Professor, University of Western Australia
Verified email at - Homepage
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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
SA Yuzwa, MS Macauley, JE Heinonen, X Shan, RJ Dennis, Y He, ...
Nature chemical biology 4 (8), 483-490, 2008
Perturbation of Indole-3-Butyric Acid Homeostasis by the UDP-Glucosyltransferase UGT74E2 Modulates Arabidopsis Architecture and Water Stress Tolerance
VB Tognetti, O Van Aken, K Morreel, K Vandenbroucke, B Van De Cotte, ...
The Plant Cell 22 (8), 2660-2679, 2010
Structure and mechanism of a bacterial β-glucosaminidase having O-GlcNAcase activity
RJ Dennis, EJ Taylor, MS Macauley, KA Stubbs, JP Turkenburg, SJ Hart, ...
Nature structural & molecular biology 13 (4), 365-371, 2006
Analysis of PUGNAc and NAG-thiazoline as Transition State Analogues for Human O-GlcNAcase:  Mechanistic and Structural Insights into Inhibitor Selectivity and …
GE Whitworth, MS Macauley, KA Stubbs, RJ Dennis, EJ Taylor, GJ Davies, ...
Journal of the American Chemical Society 129 (3), 635-644, 2007
Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated β-lactam resistance
KA Stubbs, M Balcewich, BL Mark, DJ Vocadlo
Journal of Biological Chemistry 282 (29), 21382-21391, 2007
Identification of Asp174 and Asp175 as the Key Catalytic Residues of Human O-GlcNAcase by Functional Analysis of Site-Directed Mutants
N Çetinbaş, MS Macauley, KA Stubbs, R Drapala, DJ Vocadlo
Biochemistry 45 (11), 3835-3844, 2006
Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB
E Ficko-Blean, KA Stubbs, O Nemirovsky, DJ Vocadlo, AB Boraston
Proceedings of the National Academy of Sciences 105 (18), 6560-6565, 2008
The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin
C Wanty, A Anandan, S Piek, J Walshe, J Ganguly, RW Carlson, ...
Journal of molecular biology 425 (18), 3389-3402, 2013
Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding
A Anandan, GL Evans, K Condic-Jurkic, ML O’Mara, CM John, NJ Phillips, ...
Proceedings of the National Academy of Sciences 114 (9), 2218-2223, 2017
Synthesis and Use of Mechanism-Based Protein-Profiling Probes for Retaining β-d-Glucosaminidases Facilitate Identification of Pseudomonas aeruginosa NagZ
KA Stubbs, A Scaffidi, AW Debowski, BL Mark, RV Stick, DJ Vocadlo
Journal of the American Chemical Society 130 (1), 327-335, 2008
Carrageenan catabolism is encoded by a complex regulon in marine heterotrophic bacteria
E Ficko-Blean, A Préchoux, F Thomas, T Rochat, R Larocque, Y Zhu, ...
Nature communications 8 (1), 1-17, 2017
O-GlcNAcase Catalyzes Cleavage of Thioglycosides without General Acid Catalysis
MS Macauley, KA Stubbs, DJ Vocadlo
Journal of the American Chemical Society 127 (49), 17202-17203, 2005
Visualizing the reaction coordinate of an O-GlcNAc hydrolase
Y He, MS Macauley, KA Stubbs, DJ Vocadlo, GJ Davies
Journal of the American Chemical Society 132 (6), 1807-1809, 2010
Optimising a vortex fluidic device for controlling chemical reactivity and selectivity
L Yasmin, X Chen, KA Stubbs, CL Raston
Scientific reports 3 (1), 1-6, 2013
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes
MS Macauley, Y He, TM Gloster, KA Stubbs, GJ Davies, DJ Vocadlo
Chemistry & biology 17 (9), 937-948, 2010
A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase
KA Stubbs, N Zhang, DJ Vocadlo
Organic & Biomolecular Chemistry 4 (5), 839-845, 2006
Active site plasticity within the glycoside hydrolase NagZ underlies a dynamic mechanism of substrate distortion
JP Bacik, GE Whitworth, KA Stubbs, DJ Vocadlo, BL Mark
Chemistry & biology 19 (11), 1471-1482, 2012
Inactivation of the Glycoside Hydrolase NagZ Attenuates Antipseudomonal β-Lactam Resistance in Pseudomonas aeruginosa
A Asgarali, KA Stubbs, A Oliver, DJ Vocadlo, BL Mark
Antimicrobial agents and chemotherapy 53 (6), 2274-2282, 2009
Molecular insight into evolution of symbiosis between breast-fed infants and a member of the human gut microbiome Bifidobacterium longum
C Yamada, A Gotoh, M Sakanaka, M Hattie, KA Stubbs, ...
Cell chemical biology 24 (4), 515-524. e5, 2017
Vortex fluidic chemical transformations
J Britton, KA Stubbs, GA Weiss, CL Raston
Chemistry–A European Journal 23 (54), 13270-13278, 2017
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