| Disulfide-rich macrocyclic peptides as templates in drug design SE Northfield, CK Wang, CI Schroeder, T Durek, MW Kan, JE Swedberg, ... European Journal of Medicinal Chemistry 77, 248-257, 2014 | 140 | 2014 |
| Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4 JE Swedberg, LV Nigon, JC Reid, SJ de Veer, CM Walpole, CR Stephens, ... Chemistry & biology 16 (6), 633-643, 2009 | 140 | 2009 |
| Cyclotides as a basis for drug design DJ Craik, JE Swedberg, JS Mylne, M Cemazar Expert opinion on drug discovery 7 (3), 179-194, 2012 | 139 | 2012 |
| Conformational flexibility is a determinant of permeability for cyclosporin CK Wang, JE Swedberg, PJ Harvey, Q Kaas, DJ Craik The Journal of Physical Chemistry B 122 (8), 2261-2276, 2018 | 110 | 2018 |
| Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability CK Wang, SE Northfield, JE Swedberg, B Colless, S Chaousis, DA Price, ... European Journal of Medicinal Chemistry 97, 202-213, 2015 | 89 | 2015 |
| Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network JE Swedberg, SJ de Veer, KC Sit, CF Reboul, AM Buckle, JM Harris PloS one 6 (4), e19302, 2011 | 84 | 2011 |
| Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro CI Schroeder, JE Swedberg, JM Withka, KJ Rosengren, M Akcan, ... Chemistry & biology 21 (2), 284-294, 2014 | 80 | 2014 |
| Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment Y Dong, C Stephens, C Walpole, JE Swedberg, GM Boyle, PG Parsons, ... PloS one 8 (2), e57056, 2013 | 69 | 2013 |
| Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition SJ de Veer, JE Swedberg, M Akcan, KJ Rosengren, M Brattsand, DJ Craik, ... Biochemical Journal 469 (2), 243-253, 2015 | 68 | 2015 |
| Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum SJ de Veer, L Furio, JE Swedberg, CA Munro, M Brattsand, JA Clements, ... Journal of Investigative Dermatology 137 (2), 430-439, 2017 | 65 | 2017 |
| The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37 °C W Huston, Swedberg, J E, J Harris, TP Walsh, S Mathews, P Timms FEBS Letters 581 (18), 3382-3386, 2007 | 56 | 2007 |
| Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library SJ de Veer, CK Wang, JM Harris, DJ Craik, JE Swedberg Journal of medicinal chemistry 58 (20), 8257-8268, 2015 | 55 | 2015 |
| Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold JE Swedberg, CY Li, SJ De Veer, CK Wang, DJ Craik Journal of Medicinal Chemistry 60 (2), 658-667, 2017 | 50 | 2017 |
| Mechanism‐based selection of a potent kallikrein‐related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI‐1 SJ De Veer, SS Ukolova, CA Munro, JE Swedberg, AM Buckle, JM Harris Peptide Science 100 (5), 510-518, 2013 | 47 | 2013 |
| Natural and engineered kallikrein inhibitors: an emerging pharmacopoeia JE Swedberg, SJ de Veer, JM Harris Walter de Gruyter 391 (4), 357-374, 2010 | 44 | 2010 |
| Plasmin substrate binding site cooperativity guides the design of potent peptide aldehyde inhibitors JE Swedberg, JM Harris Biochemistry 50 (39), 8454-8462, 2011 | 41 | 2011 |
| Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold JE Swedberg, T Mahatmanto, H Abdul Ghani, SJ de Veer, CI Schroeder, ... Journal of Medicinal Chemistry 59 (15), 7287-7292, 2016 | 38 | 2016 |
| Effects of cyclization on peptide backbone dynamics CK Wang, JE Swedberg, SE Northfield, DJ Craik The journal of physical chemistry B 119 (52), 15821-15830, 2015 | 38 | 2015 |
| Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14 SJ de Veer, JE Swedberg, EA Parker, JM Harris Biological chemistry 393 (5), 331-341, 2012 | 37 | 2012 |
| Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors SJ De Veer, JE Swedberg, M Brattsand, JA Clements, JM Harris Biological chemistry 397 (12), 1237-1249, 2016 | 35 | 2016 |
