|Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4|
JE Swedberg, LV Nigon, JC Reid, SJ de Veer, CM Walpole, CR Stephens, ...
Chemistry & biology 16 (6), 633-643, 2009
|Cyclotides as a basis for drug design|
DJ Craik, JE Swedberg, JS Mylne, M Cemazar
Expert opinion on drug discovery 7 (3), 179-194, 2012
|Disulfide-rich macrocyclic peptides as templates in drug design|
SE Northfield, CK Wang, CI Schroeder, T Durek, MW Kan, JE Swedberg, ...
European Journal of Medicinal Chemistry 77, 248-257, 2014
|Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network|
JE Swedberg, SJ De Veer, KC Sit, CF Reboul, AM Buckle, JM Harris
PloS one 6 (4), e19302, 2011
|Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment|
Y Dong, C Stephens, C Walpole, JE Swedberg, GM Boyle, PG Parsons, ...
PloS one 8 (2), e57056, 2013
|The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37 °C|
W Huston, Swedberg, J E, J Harris, TP Walsh, S Mathews, P Timms
FEBS Letters 581 (18), 3382-3386, 2007
|Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition|
SJ de Veer, JE Swedberg, M Akcan, KJ Rosengren, M Brattsand, DJ Craik, ...
Biochemical Journal 469 (2), 243-253, 2015
|Exploring experimental and computational markers of cyclic peptides: charting islands of permeability|
CK Wang, SE Northfield, JE Swedberg, B Colless, S Chaousis, DA Price, ...
European journal of medicinal chemistry 97, 202-213, 2015
|Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro|
CI Schroeder, JE Swedberg, JM Withka, KJ Rosengren, M Akcan, ...
Chemistry & Biology 21 (2), 284-294, 2014
|Natural and engineered kallikrein inhibitors: an emerging pharmacopoeia|
JE Swedberg, SJ de Veer, JM Harris
Biological chemistry 391 (4), 357-374, 2010
|Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library|
SJ de Veer, CK Wang, JM Harris, DJ Craik, JE Swedberg
Journal of medicinal chemistry 58 (20), 8257-8268, 2015
|Mechanism‐based selection of a potent kallikrein‐related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI‐1|
SJ De Veer, SS Ukolova, CA Munro, JE Swedberg, AM Buckle, JM Harris
Peptide Science 100 (5), 510-518, 2013
|Plasmin substrate binding site cooperativity guides the design of potent peptide aldehyde inhibitors|
JE Swedberg, JM Harris
Biochemistry 50 (39), 8454-8462, 2011
|Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum|
SJ de Veer, L Furio, JE Swedberg, CA Munro, M Brattsand, JA Clements, ...
Journal of Investigative Dermatology 137 (2), 430-439, 2017
|Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14|
SJ De Veer, JE Swedberg, EA Parker, JM Harris
Biological chemistry 393 (5), 331-341, 2012
|Conformational flexibility is a determinant of permeability for cyclosporin|
CK Wang, JE Swedberg, PJ Harvey, Q Kaas, DJ Craik
The Journal of Physical Chemistry B 122 (8), 2261-2276, 2018
|Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold|
JE Swedberg, CY Li, SJ De Veer, CK Wang, DJ Craik
Journal of medicinal chemistry 60 (2), 658-667, 2017
|Effects of cyclization on peptide backbone dynamics|
CK Wang, JE Swedberg, SE Northfield, DJ Craik
The journal of physical chemistry B 119 (52), 15821-15830, 2015
|Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics|
BT Riley, O Ilyichova, MGS Costa, BT Porebski, SJ De Veer, JE Swedberg, ...
Scientific reports 6, 35385, 2016
|Natural and engineered plasmin inhibitors: applications and design strategies|
JE Swedberg, JM Harris
Chembiochem 13 (3), 336, 2012