John C. Bell
John C. Bell
Senior Scientist Ottawa Hospital Research Institute
Verified email at
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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
HP Harding, Y Zhang, H Zeng, I Novoa, PD Lu, M Calfon, N Sadri, C Yun, ...
Molecular cell 11 (3), 619-633, 2003
Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase
GE Hannigan, C Leung-Hagesteijn, L Fitz-Gibbon, MG Coppolino, ...
Nature 379 (6560), 91-96, 1996
Oncolytic virotherapy
SJ Russell, KW Peng, JC Bell
Nature biotechnology 30 (7), 658, 2012
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus
DF Stojdl, B Lichty, S Knowles, R Marius, H Atkins, N Sonenberg, JC Bell
Nature medicine 6 (7), 821-825, 2000
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents
DF Stojdl, BD Lichty, JM Paterson, AT Power, S Knowles, R Marius, ...
Cancer cell 4 (4), 263-275, 2003
ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
M Bi, C Naczki, M Koritzinsky, D Fels, J Blais, N Hu, H Harding, I Novoa, ...
The EMBO journal 24 (19), 3470-3481, 2005
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.
K Colwill, T Pawson, B Andrews, J Prasad, JL Manley, JC Bell, PI Duncan
The EMBO journal 15 (2), 265-275, 1996
Recent progress in the battle between oncolytic viruses and tumours
KA Parato, D Senger, PAJ Forsyth, JC Bell
Nature Reviews Cancer 5 (12), 965, 2005
Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer
J Heo, T Reid, L Ruo, CJ Breitbach, S Rose, M Bloomston, M Cho, HY Lim, ...
Nature medicine 19 (3), 329, 2013
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans
CJ Breitbach, J Burke, D Jonker, J Stephenson, AR Haas, LQM Chow, ...
Nature 477 (7362), 99-102, 2011
Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial
BH Park, T Hwang, TC Liu, DY Sze, JS Kim, HC Kwon, SY Oh, SY Han, ...
The lancet oncology 9 (6), 533-542, 2008
Going viral with cancer immunotherapy
BD Lichty, CJ Breitbach, DF Stojdl, JC Bell
Nature Reviews Cancer 14 (8), 559-567, 2014
Activating transcription factor 4 is translationally regulated by hypoxic stress
JD Blais, V Filipenko, M Bi, HP Harding, D Ron, C Koumenis, BG Wouters, ...
Molecular and cellular biology 24 (17), 7469-7482, 2004
Vesicular stomatitis virus: re-inventing the bullet
BD Lichty, AT Power, DF Stojdl, JC Bell
Trends in molecular medicine 10 (5), 210-216, 2004
Cloning and characterization of a second member of the mouse mdr gene family.
P Gros, M Raymond, J Bell, D Housman
Molecular and Cellular Biology 8 (7), 2770-2778, 1988
Translational control of the innate immune response through IRF-7
R Colina, M Costa-Mattioli, RJO Dowling, M Jaramillo, LH Tai, ...
Nature 452 (7185), 323-328, 2008
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress
JD Blais, CL Addison, R Edge, T Falls, H Zhao, K Wary, C Koumenis, ...
Molecular and cellular biology 26 (24), 9517-9532, 2006
Targeted inflammation during oncolytic virus therapy severely compromises tumor blood flow
CJ Breitbach, JM Paterson, CG Lemay, TJ Falls, A McGuire, KA Parato, ...
Molecular Therapy 15 (9), 1686-1693, 2007
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR
N Abraham, DF Stojdl, PI Duncan, N Méthot, T Ishii, M Dubé, ...
Journal of Biological Chemistry 274 (9), 5953-5962, 1999
Whole‐genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom
K MacKay, S Eyre, A Myerscough, A Milicic, A Barton, S Laval, J Barrett, ...
Arthritis & Rheumatism 46 (3), 632-639, 2002
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