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William Pao
William Pao
Verified email at roche.com
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Year
EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib
W Pao, V Miller, M Zakowski, J Doherty, K Politi, I Sarkaria, B Singh, ...
Proceedings of the National Academy of Sciences 101 (36), 13306-13311, 2004
53672004
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
W Pao, VA Miller, KA Politi, GJ Riely, R Somwar, MF Zakowski, MG Kris, ...
PLoS medicine 2 (3), e73, 2005
42812005
Comprehensive genomic characterization of squamous cell lung cancers
Cancer Genome Atlas Research Network
Nature 489 (7417), 519, 2012
36492012
Somatic mutations affect key pathways in lung adenocarcinoma
L Ding, G Getz, DA Wheeler, ER Mardis, MD McLellan, K Cibulskis, ...
Nature 455 (7216), 1069-1075, 2008
30952008
Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers
HA Yu, ME Arcila, N Rekhtman, CS Sima, MF Zakowski, W Pao, MG Kris, ...
Clinical cancer research 19 (8), 2240-2247, 2013
25892013
AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer
DAE Cross, SE Ashton, S Ghiorghiu, C Eberlein, CA Nebhan, PJ Spitzler, ...
Cancer discovery 4 (9), 1046-1061, 2014
20882014
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
M Imielinski, AH Berger, PS Hammerman, B Hernandez, TJ Pugh, ...
Cell 150 (6), 1107-1120, 2012
19762012
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
J Bean, C Brennan, JY Shih, G Riely, A Viale, L Wang, D Chitale, N Motoi, ...
Proceedings of the National Academy of Sciences 104 (52), 20932-20937, 2007
19492007
KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib
W Pao, TY Wang, GJ Riely, VA Miller, Q Pan, M Ladanyi, MF Zakowski, ...
PLoS medicine 2 (1), e17, 2005
19432005
ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers
K Bergethon, AT Shaw, SH Ignatius Ou, R Katayama, CM Lovly, ...
Journal of clinical oncology 30 (8), 863-870, 2012
19412012
Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
MG Kris, BE Johnson, LD Berry, DJ Kwiatkowski, AJ Iafrate, II Wistuba, ...
Jama 311 (19), 1998-2006, 2014
17822014
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
M Peifer, L Fernández-Cuesta, ML Sos, J George, D Seidel, LH Kasper, ...
Nature genetics 44 (10), 1104-1110, 2012
14612012
New driver mutations in non-small-cell lung cancer
W Pao, N Girard
The lancet oncology 12 (2), 175-180, 2011
14472011
Characterizing the cancer genome in lung adenocarcinoma
BA Weir, MS Woo, G Getz, S Perner, L Ding, R Beroukhim, WM Lin, ...
Nature 450 (7171), 893-898, 2007
12752007
Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer
W Pao, J Chmielecki
Nature Reviews Cancer 10 (11), 760-774, 2010
12212010
American Society of Clinical Oncology clinical practice guideline update on chemotherapy for stage IV non–small-cell lung cancer
CG Azzoli, S Baker Jr, S Temin, W Pao, T Aliff, J Brahmer, DH Johnson, ...
Journal of clinical oncology 27 (36), 6251, 2009
10552009
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
J Weiss, ML Sos, D Seidel, M Peifer, T Zander, JM Heuckmann, RT Ullrich, ...
Science translational medicine 2 (62), 62ra93-62ra93, 2010
10072010
Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor–mutant lung adenocarcinomas with acquired resistance to kinase inhibitors
MN Balak, Y Gong, GJ Riely, R Somwar, AR Li, MF Zakowski, A Chiang, ...
Clinical cancer research 12 (21), 6494-6501, 2006
9712006
Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non–small-cell lung cancer
D Jackman, W Pao, GJ Riely, JA Engelman, MG Kris, PA Jänne, T Lynch, ...
Journal of clinical oncology 28 (2), 357, 2010
9542010
Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer
VA Miller, MG Kris
Oncology Times 26 (11), 69-70, 2004
9542004
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