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Kaiwen Chen
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Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps
KW Chen, M Monteleone, D Boucher, G Sollberger, D Ramnath, ...
Science immunology 3 (26), eaar6676, 2018
4812018
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
D Boucher, M Monteleone, RC Coll, KW Chen, CM Ross, JL Teo, ...
Journal of Experimental Medicine 215 (3), 827-840, 2018
4552018
The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge
KW Chen, CJ Groß, FV Sotomayor, KJ Stacey, J Tschopp, MJ Sweet, ...
Cell reports 8 (2), 570-582, 2014
4142014
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
SA Conos, KW Chen, D De Nardo, H Hara, L Whitehead, G Núñez, ...
Proceedings of the National Academy of Sciences 114 (6), E961-E969, 2017
3812017
Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly
KW Chen, B Demarco, R Heilig, K Shkarina, A Boettcher, CJ Farady, ...
The EMBO journal 38 (10), e101638, 2019
3092019
Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and-independent secretion
M Monteleone, AC Stanley, KW Chen, DL Brown, JS Bezbradica, ...
Cell reports 24 (6), 1425-1433, 2018
2642018
Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
JC Santos, D Boucher, LK Schneider, B Demarco, M Dilucca, K Shkarina, ...
Nature communications 11 (1), 3276, 2020
1992020
Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality
B Demarco, JP Grayczyk, E Bjanes, D Le Roy, W Tonnus, ...
Science advances 6 (47), eabc3465, 2020
1432020
XIAP loss triggers RIPK3-and caspase-8-driven IL-1β activation and cell death as a consequence of TLR-MyD88-induced cIAP1-TRAF2 degradation
KE Lawlor, R Feltham, M Yabal, SA Conos, KW Chen, S Ziehe, C Graß, ...
Cell reports 20 (3), 668-682, 2017
1282017
Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling
L Luo, AA Wall, JC Yeo, ND Condon, SJ Norwood, S Schoenwaelder, ...
Nature communications 5 (1), 4407, 2014
1242014
A novel flow cytometric method to assess inflammasome formation
DP Sester, SJ Thygesen, V Sagulenko, PR Vajjhala, JA Cridland, N Vitak, ...
The Journal of Immunology 194 (1), 455-462, 2015
1062015
RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling
KW Chen, B Demarco, S Ramos, R Heilig, M Goris, JP Grayczyk, ...
Proceedings of the National Academy of Sciences 118 (28), e2101189118, 2021
782021
Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis
KW Chen, B Demarco, P Broz
The EMBO journal 39 (2), e103397, 2020
722020
Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or Non‐canonical inflammasome activation
KW Chen, B Demarco, P Broz
European journal of immunology, 2019
712019
An antioxidant role for catecholate siderophores in Salmonella
MES Achard, KW Chen, MJ Sweet, RE Watts, K Schroder, MA Schembri, ...
Biochemical Journal 454 (3), 543-549, 2013
662013
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD
R Heilig, M Dilucca, D Boucher, KW Chen, D Hancz, B Demarco, ...
Life science alliance 3 (6), 2020
652020
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome
KS Robinson, GA Toh, P Rozario, R Chua, S Bauernfried, Z Sun, ...
Science 377 (6603), 328-335, 2022
592022
Antimicrobial functions of inflammasomes
KW Chen, K Schroder
Current opinion in microbiology 16 (3), 311-318, 2013
552013
Posttranslational and therapeutic control of gasdermin-mediated pyroptosis and inflammation
FA Fischer, KW Chen, JS Bezbradica
Frontiers in immunology 12, 661162, 2021
502021
Cross talk between intracellular pathogens and cell death
B Demarco, KW Chen, P Broz
Immunological reviews 297 (1), 174-193, 2020
462020
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Articles 1–20