Kaiwen Chen
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The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge
KW Chen, CJ Gro▀, FV Sotomayor, KJ Stacey, J Tschopp, MJ Sweet, ...
Cell reports 8 (2), 570-582, 2014
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
SA Conos, KW Chen, D De Nardo, H Hara, L Whitehead, G N˙˝ez, ...
Proceedings of the National Academy of Sciences 114 (6), E961-E969, 2017
Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps
KW Chen, M Monteleone, D Boucher, G Sollberger, D Ramnath, ...
Science immunology 3 (26), 2018
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
D Boucher, M Monteleone, RC Coll, KW Chen, CM Ross, JL Teo, ...
Journal of Experimental Medicine 215 (3), 827-840, 2018
Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and-independent secretion
M Monteleone, AC Stanley, KW Chen, DL Brown, JS Bezbradica, ...
Cell reports 24 (6), 1425-1433, 2018
Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly
KW Chen, B Demarco, R Heilig, K Shkarina, A Boettcher, CJ Farady, ...
The EMBO journal 38 (10), e101638, 2019
Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling
L Luo, AA Wall, JC Yeo, ND Condon, SJ Norwood, S Schoenwaelder, ...
Nature communications 5 (1), 1-13, 2014
XIAP loss triggers RIPK3-and caspase-8-driven IL-1β activation and cell death as a consequence of TLR-MyD88-induced cIAP1-TRAF2 degradation
KE Lawlor, R Feltham, M Yabal, SA Conos, KW Chen, S Ziehe, C Gra▀, ...
Cell reports 20 (3), 668-682, 2017
A novel flow cytometric method to assess inflammasome formation
DP Sester, SJ Thygesen, V Sagulenko, PR Vajjhala, JA Cridland, N Vitak, ...
The Journal of Immunology 194 (1), 455-462, 2015
An antioxidant role for catecholate siderophores in Salmonella
MES Achard, KW Chen, MJ Sweet, RE Watts, K Schroder, MA Schembri, ...
Biochemical Journal 454 (3), 543-549, 2013
Antimicrobial functions of inflammasomes
KW Chen, K Schroder
Current opinion in microbiology 16 (3), 311-318, 2013
Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
JC Santos, D Boucher, LK Schneider, B Demarco, M Dilucca, K Shkarina, ...
Nature communications 11 (1), 1-15, 2020
NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS-or infection-induced NF-κB or ERK signalling
A Zamoshnikova, CJ Gro▀, S Schuster, KW Chen, A Wilson, ...
Immunobiology 221 (2), 341-346, 2016
Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or Non‐canonical inflammasome activation
KW Chen, B Demarco, P Broz
European journal of immunology, 2019
The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists
KW Chen, JS Bezbradica, CJ Gro▀, AA Wall, MJ Sweet, JL Stow, ...
European journal of immunology 46 (4), 1004-1010, 2016
Cutting edge: Blockade of inhibitor of apoptosis proteins sensitizes neutrophils to TNF-but not lipopolysaccharide-mediated cell death and IL-1β secretion
KW Chen, KE Lawlor, JB Von Pein, D Boucher, M Gerlic, BA Croker, ...
The Journal of Immunology 200 (10), 3341-3346, 2018
Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality
B Demarco, JP Grayczyk, E Bjanes, D Le Roy, W Tonnus, ...
Science advances 6 (47), eabc3465, 2020
Beyond inflammasomes: Emerging function of gasdermins during apoptosis and NETosis
KW Chen, B Demarco, P Broz
The EMBO journal 39 (2), e103397, 2020
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD
R Heilig, M Dilucca, D Boucher, KW Chen, D Hancz, B Demarco, ...
Life science alliance 3 (6), 2020
Burn the house, save the day: pyroptosis in pathogen restriction
D Boucher, KW Chen, K Schroder
Inflammasome 2 (1), 1-6, 2016
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