Meritxell Canals
Meritxell Canals
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Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1–A2A receptor heteromers
F Ciruela, V Casadó, RJ Rodrigues, R Luján, J Burgueno, M Canals, ...
Journal of Neuroscience 26 (7), 2080-2087, 2006
Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2Receptors
J Hillion, M Canals, M Torvinen, V Casadó, R Scott, A Terasmaa, ...
Journal of Biological Chemistry 277 (20), 18091-18097, 2002
Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer
M Canals, D Marcellino, F Fanelli, F Ciruela, P De Benedetti, ...
Journal of Biological Chemistry 278 (47), 46741-46749, 2003
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
RO Dror, HF Green, C Valant, DW Borhani, JR Valcourt, AC Pan, ...
Nature 503 (7475), 295-299, 2013
Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson’s disease
K Fuxe, LF Agnati, K Jacobsen, J Hillion, M Canals, M Torvinen, ...
Neurology 61 (11 suppl 6), S19-S23, 2003
Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function
K Fuxe, S Ferré, M Canals, M Torvinen, A Terasmaa, D Marcellino, ...
Journal of molecular neuroscience 26 (2), 209-220, 2005
Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and-independent coordinated alterations of receptor localization and function
J Ellis, JD Pediani, M Canals, S Milasta, G Milligan
Journal of Biological Chemistry 281 (50), 38812-38824, 2006
The role of kinetic context in apparent biased agonism at GPCRs
C Klein Herenbrink, DA Sykes, P Donthamsetti, M Canals, T Coudrat, ...
Nature communications 7 (1), 1-14, 2016
Pharmacological modulation of chemokine receptor function
DJ Scholten, M Canals, D Maussang, L Roumen, MJ Smit, M Wijtmans, ...
British journal of pharmacology 165 (6), 1617-1643, 2012
Combining Mass Spectrometry and Pull-Down Techniques for the Study of Receptor Heteromerization. Direct Epitope− Epitope Electrostatic Interactions between Adenosine A2A and …
F Ciruela, J Burgueño, V Casadó, M Canals, D Marcellino, SR Goldberg, ...
Analytical Chemistry 76 (18), 5354-5363, 2004
Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer
M Canals, J Burgueño, D Marcellino, N Cabello, EI Canela, J Mallol, ...
Journal of neurochemistry 88 (3), 726-734, 2004
The α1b-adrenoceptor exists as a higher-order oligomer: effective oligomerization is required for receptor maturation, surface delivery, and function
JF Lopez-Gimenez, M Canals, JD Pediani, G Milligan
Molecular pharmacology 71 (4), 1015-1029, 2007
Adenosine A2A-dopamine D2 receptor–receptor heteromers. Targets for neuro-psychiatric disorders
S Ferré, F Ciruela, M Canals, D Marcellino, J Burgueno, V Casadó, ...
Parkinsonism & related disorders 10 (5), 265-271, 2004
Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells
AI Idris, A Sophocleous, E Landao-Bassonga, M Canals, G Milligan, ...
Cell Metabolism 10 (2), 139-147, 2009
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
A Gillis, AB Gondin, A Kliewer, J Sanchez, HD Lim, C Alamein, ...
Science Signaling 13 (625), eaaz3140, 2020
Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes
M Torvinen, D Marcellino, M Canals, LF Agnati, C Lluis, R Franco, K Fuxe
Molecular pharmacology 67 (2), 400-407, 2005
Intramembrane receptor–receptor interactions: a novel principle in molecular medicine
K Fuxe, M Canals, M Torvinen, D Marcellino, A Terasmaa, S Genedani, ...
Journal of neural transmission 114 (1), 49-75, 2007
Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain
L Giménez-Llort, SN Schiffmann, T Shmidt, L Canela, L Camón, ...
Neurobiology of learning and memory 87 (1), 42-56, 2007
A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation
M Canals, JR Lane, A Wen, PJ Scammells, PM Sexton, A Christopoulos
Journal of Biological Chemistry 287 (1), 650-659, 2012
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief
DD Jensen, TM Lieu, ML Halls, NA Veldhuis, WL Imlach, QN Mai, ...
Science Translational Medicine 9 (392), eaal3447, 2017
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