| Targeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunities B Hong, PJ van den Heuvel, V V Prabhu, S Zhang, W S El-Deiry Current drug targets 15 (1), 80-89, 2014 | 286 | 2014 |
| ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases CLB Kline, APJ Van den Heuvel, JE Allen, VV Prabhu, DT Dicker, ... Science signaling 9 (415), ra18-ra18, 2016 | 179 | 2016 |
| Discovery and clinical introduction of first-in-class imipridone ONC201 JE Allen, CLB Kline, VV Prabhu, J Wagner, J Ishizawa, N Madhukar, ... Oncotarget 7 (45), 74380, 2016 | 140 | 2016 |
| Small-molecule ONC201/TIC10 targets chemotherapy-resistant colorectal cancer stem–like cells in an Akt/Foxo3a/TRAIL–dependent manner VV Prabhu, JE Allen, DT Dicker, WS El-Deiry Cancer research 75 (7), 1423-1432, 2015 | 133 | 2015 |
| Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and … R Gogada, V Prabhu, M Amadori, R Scott, S Hashmi, D Chandra Journal of Biological Chemistry 286 (33), 28749-28760, 2011 | 120 | 2011 |
| Targeting TRAIL in the treatment of cancer: new developments B Lim, JE Allen, VV Prabhu, MK Talekar, NK Finnberg, WS El-Deiry Expert opinion on therapeutic targets 19 (9), 1171-1185, 2015 | 113 | 2015 |
| ONC201 and imipridones: Anti-cancer compounds with clinical efficacy VV Prabhu, S Morrow, AR Kawakibi, L Zhou, M Ralff, J Ray, A Jhaveri, ... Neoplasia 22 (12), 725-744, 2020 | 112 | 2020 |
| Small-molecule NSC59984 restores p53 pathway signaling and antitumor effects against colorectal cancer via p73 activation and degradation of mutant p53 S Zhang, L Zhou, B Hong, APJ van den Heuvel, VV Prabhu, NA Warfel, ... Cancer research 75 (18), 3842-3852, 2015 | 105 | 2015 |
| Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53 B Hong, VV Prabhu, S Zhang, APJ van den Heuvel, DT Dicker, ... Cancer research 74 (4), 1153-1165, 2014 | 91 | 2014 |
| Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis R Gogada, M Amadori, H Zhang, A Jones, A Verone, J Pitarresi, ... Cell cycle 10 (23), 4128-4137, 2011 | 79 | 2011 |
| Metabolic reprogramming by dual AKT/ERK inhibition through imipridones elicits unique vulnerabilities in glioblastoma CT Ishida, Y Zhang, E Bianchetti, C Shu, TTT Nguyen, G Kleiner, ... Clinical Cancer Research 24 (21), 5392-5406, 2018 | 74 | 2018 |
| Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212 J Wagner, CL Kline, MD Ralff, A Lev, A Lulla, L Zhou, GL Olson, ... Cell cycle 16 (19), 1790-1799, 2017 | 67 | 2017 |
| Biological activity of weekly ONC201 in adult recurrent glioblastoma patients I Arrillaga-Romany, Y Odia, VV Prabhu, RS Tarapore, K Merdinger, ... Neuro-oncology 22 (1), 94-102, 2020 | 65 | 2020 |
| Small-molecule prodigiosin restores p53 tumor suppressor activity in chemoresistant colorectal cancer stem cells via c-Jun-mediated ΔNp73 inhibition and p73 activation VV Prabhu, B Hong, JE Allen, S Zhang, AR Lulla, DT Dicker, WS El-Deiry Cancer research 76 (7), 1989-1999, 2016 | 63 | 2016 |
| Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia T Nii, VV Prabhu, V Ruvolo, N Madhukar, R Zhao, H Mu, L Heese, ... Leukemia 33 (12), 2805-2816, 2019 | 58 | 2019 |
| Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration MN Stein, J Malhotra, RS Tarapore, U Malhotra, AW Silk, N Chan, ... Journal for immunotherapy of cancer 7, 1-9, 2019 | 56 | 2019 |
| Dopamine receptor D5 is a modulator of tumor response to dopamine receptor D2 antagonism VV Prabhu, NS Madhukar, C Gilvary, CLB Kline, S Oster, WS El-Deiry, ... Clinical Cancer Research 25 (7), 2305-2313, 2019 | 54 | 2019 |
| Resveratrol depletes mitochondrial DNA and inhibition of autophagy enhances resveratrol-induced caspase activation V Prabhu, P Srivastava, N Yadav, M Amadori, A Schneider, A Seshadri, ... Mitochondrion 13 (5), 493-499, 2013 | 51 | 2013 |
| Therapeutic targeting of the p53 pathway in cancer stem cells VV Prabhu, JE Allen, B Hong, S Zhang, H Cheng, WS El-Deiry Expert opinion on therapeutic targets 16 (12), 1161-1174, 2012 | 50 | 2012 |
| Genetic and pharmacological screens converge in identifying FLIP, BCL2, and IAP proteins as key regulators of sensitivity to the TRAIL-inducing anticancer agent ONC201/TIC10 JE Allen, VV Prabhu, M Talekar, APJ Van Den Heuvel, B Lim, DT Dicker, ... Cancer research 75 (8), 1668-1674, 2015 | 47 | 2015 |
