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Peter Orchard
Peter Orchard
Pharmatics Ltd
Verified email at pharmaticsltd.com
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Cited by
Cited by
Year
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
A Varshney, LJ Scott, RP Welch, MR Erdos, PS Chines, N Narisu, ...
Proceedings of the National Academy of Sciences 114 (9), 2301-2306, 2017
2002017
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
A Viñuela, A Varshney, M van de Bunt, RB Prasad, O Asplund, A Bennett, ...
Nature communications 11 (1), 4912, 2020
982020
Glycosylation of plasma IgG in colorectal cancer prognosis
E Theodoratou, K Thaçi, F Agakov, MN Timofeeva, J Štambuk, ...
Scientific reports 6 (1), 28098, 2016
972016
Multiomic profiling identifies cis-regulatory networks underlying human pancreatic β cell identity and function
N Lawlor, EJ Marquez, P Orchard, N Narisu, MS Shamim, A Thibodeau, ...
Cell reports 26 (3), 788-801. e6, 2019
682019
Quantification, dynamic visualization, and validation of bias in ATAC-seq data with ataqv
P Orchard, Y Kyono, J Hensley, JO Kitzman, SCJ Parker
Cell systems 10 (3), 298-306. e4, 2020
612020
Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients
JC Taylor, T Bongartz, J Massey, B Mifsud, A Spiliopoulou, IC Scott, ...
The pharmacogenomics journal 18 (4), 528-538, 2018
542018
Improving prediction of risk of hospital admission in chronic obstructive pulmonary disease: application of machine learning to telemonitoring data
P Orchard, A Agakova, H Pinnock, CD Burton, C Sarran, F Agakov, ...
Journal of medical Internet research 20 (9), e263, 2018
452018
GeneImp: fast imputation to large reference panels using genotype likelihoods from ultralow coverage sequencing
A Spiliopoulou, M Colombo, P Orchard, F Agakov, P McKeigue
Genetics 206 (1), 91-104, 2017
382017
Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits
P Orchard, N Manickam, C Ventresca, S Vadlamudi, A Varshney, V Rai, ...
Genome Research 31 (12), 2258-2275, 2021
302021
Genetic effects on liver chromatin accessibility identify disease regulatory variants
KW Currin, MR Erdos, N Narisu, V Rai, S Vadlamudi, HJ Perrin, JR Idol, ...
The American Journal of Human Genetics 108 (7), 1169-1189, 2021
252021
Chromatin information content landscapes inform transcription factor and DNA interactions
R D’Oliveira Albanus, Y Kyono, J Hensley, A Varshney, P Orchard, ...
Nature Communications 12 (1), 1307, 2021
242021
BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning
T Liu, L Mi, J Xiong, P Orchard, Q Yu, L Yu, XY Zhao, ZX Meng, ...
Nature Communications 11 (1), 2379, 2020
232020
Influence of genetic variants on gene expression in human pancreatic islets–implications for type 2 diabetes
A Viñuela, A Varshney, M van de Bunt, RB Prasad, O Asplund, A Bennett, ...
BioRxiv, 655670, 2019
172019
Cell specificity of human regulatory annotations and their genetic effects on gene expression
A Varshney, H VanRenterghem, P Orchard, AP Boyle, ML Stitzel, D Ucar, ...
Genetics 211 (2), 549-562, 2019
172019
Bayesian inference in sparse gaussian graphical models
P Orchard, F Agakov, A Storkey
arXiv preprint arXiv:1309.7311, 2013
122013
Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth’s …
P Orchard, JS White, PE Thomas, A Mychalowych, A Kiseleva, J Hensley, ...
Human Molecular Genetics 28 (5), 736-750, 2019
112019
Discriminative mixtures of sparse latent fields for risk management
F Agakov, P Orchard, A Storkey
Artificial Intelligence and Statistics, 10-18, 2012
112012
Comprehensive enhancer-target gene assignments improve gene set level interpretation of genome-wide regulatory data
T Qin, C Lee, S Li, RG Cavalcante, P Orchard, H Yao, H Zhang, S Wang, ...
Genome Biology 23 (1), 105, 2022
102022
A transcription start site map in human pancreatic islets reveals functional regulatory signatures
A Varshney, Y Kyono, VR Elangovan, C Wang, MR Erdos, N Narisu, ...
Diabetes 70 (7), 1581-1591, 2021
102021
RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes
JT Walker, DC Saunders, V Rai, C Dai, P Orchard, AL Hopkirk, ...
BioRxiv, 2021.12. 16.466282, 2021
82021
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