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Gustavo Fenalti
Gustavo Fenalti
Director of Structural Biology and Molecular Design
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Cited by
Year
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
B Wu, EYT Chien, CD Mol, G Fenalti, W Liu, V Katritch, R Abagyan, ...
Science 330 (6007), 1066-1071, 2010
20992010
Structure of the CCR5 chemokine receptor–HIV entry inhibitor maraviroc complex
Q Tan, Y Zhu, J Li, Z Chen, GW Han, I Kufareva, T Li, L Ma, G Fenalti, J Li, ...
Science 341 (6152), 1387-1390, 2013
8032013
Molecular control of δ-opioid receptor signalling
G Fenalti, PM Giguere, V Katritch, XP Huang, AA Thompson, V Cherezov, ...
Nature 506 (7487), 191-196, 2014
5372014
Allosteric sodium in class A GPCR signaling
V Katritch, G Fenalti, EE Abola, BL Roth, V Cherezov, RC Stevens
Trends in biochemical sciences 39 (5), 233-244, 2014
4882014
Structure of the human P2Y12 receptor in complex with an antithrombotic drug
K Zhang, J Zhang, ZG Gao, D Zhang, L Zhu, GW Han, SM Moss, ...
Nature 509 (7498), 115-118, 2014
4332014
Conserved Binding Mode of Human β2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
D Wacker, G Fenalti, MA Brown, V Katritch, R Abagyan, V Cherezov, ...
Journal of the American Chemical Society 132 (33), 11443-11445, 2010
4242010
Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine
L Qin, I Kufareva, LG Holden, C Wang, Y Zheng, C Zhao, G Fenalti, H Wu, ...
Science 347 (6226), 1117-1122, 2015
4132015
GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop
G Fenalti, RHP Law, AM Buckle, C Langendorf, K Tuck, CJ Rosado, ...
Nature structural & molecular biology 14 (4), 280-286, 2007
2552007
Structural basis for bifunctional peptide recognition at human δ-opioid receptor
G Fenalti, NA Zatsepin, C Betti, P Giguere, GW Han, A Ishchenko, W Liu, ...
Nature structural & molecular biology 22 (3), 265-268, 2015
1922015
Structural biology of the GAD autoantigen
G Fenalti, AM Buckle
Autoimmunity reviews 9 (3), 148-152, 2010
682010
COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity
G Fenalti, CS Hampe, Y Arafat, RHP Law, JP Banga, IR Mackay, ...
Diabetes 57 (5), 1293-1301, 2008
512008
The X-Ray Crystal Structure of Escherichia coli Succinic Semialdehyde Dehydrogenase; Structural Insights into NADP+/Enzyme Interactions
CG Langendorf, TLG Key, G Fenalti, WT Kan, AM Buckle, ...
PLoS One 5 (2), e9280, 2010
402010
GAD65 as a prototypic autoantigen
G Fenalti, MJ Rowley
Journal of autoimmunity 31 (3), 228-232, 2008
322008
Structure of the human marker of self 5-transmembrane receptor CD47
G Fenalti, N Villanueva, M Griffith, B Pagarigan, SK Lakkaraju, ...
Nature communications 12 (1), 5218, 2021
262021
Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates
CG Langendorf, KL Tuck, TLG Key, G Fenalti, RN Pike, CJ Rosado, ...
Bioscience reports 33 (1), e00013, 2013
252013
A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer
I Kufareva, B Stephens, CT Gilliland, B Wu, G Fenalti, D Hamel, ...
Chemokines: Methods and Protocols, 93-127, 2013
242013
Structural determinants of GAD antigenicity
Y Arafat, G Fenalti, JC Whisstock, IR Mackay, MG de la Banda, MJ Rowley, ...
Molecular immunology 47 (2-3), 493-505, 2009
242009
Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96. 11
G Fenalti, CS Hampe, K O’Connor, JP Banga, IR Mackay, MJ Rowley, ...
Molecular immunology 44 (6), 1178-1189, 2007
202007
Design and optimization leading to an orally active TTK protein kinase inhibitor with robust single agent efficacy
JR Riggs, J Elsner, D Cashion, D Robinson, L Tehrani, M Nagy, KE Fultz, ...
Journal of Medicinal Chemistry 62 (9), 4401-4410, 2019
152019
Fluorescence recovery after photobleaching in Lipidic Cubic Phase (LCP-FRAP): a precrystallization assay for membrane proteins
G Fenalti, EE Abola, C Wang, B Wu, V Cherezov
Methods in enzymology 557, 417-437, 2015
112015
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