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Zheng Ruan (阮铮)
Zheng Ruan (阮铮)
Assistant Professor, Thomas Jefferson University
Verified email at jefferson.edu - Homepage
Title
Cited by
Cited by
Year
Structures of human pannexin 1 reveal ion pathways and mechanism of gating
Z Ruan, IJ Orozco, J Du, W Lü
Nature 584 (7822), 646–651, 2020
1472020
STRAW: species TRee analysis web server
TI Shaw, Z Ruan, TC Glenn, L Liu
Nucleic acids research 41 (W1), W238-W241, 2013
1132013
Cerebellar ataxia and coenzyme Q deficiency through loss of unorthodox kinase activity
JA Stefely, F Licitra, L Laredj, AG Reidenbach, ZA Kemmerer, ...
Molecular cell 63 (4), 608-620, 2016
1112016
Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1
SA Jamieson*, Z Ruan*, AE Burgess, JR Curry, HD McMillan, JL Brewster, ...
Science Signaling 11 (549), eaau0597, 2018
582018
Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC–β4 loop insertion mutations
Z Ruan, N Kannan
Proceedings of the National Academy of Sciences of USA 115 (35), E8162-E8171, 2018
582018
Structures and pH-sensing mechanism of the proton-activated chloride channel
Z Ruan*, J Osei-Owusu*, J Du, Z Qiu, W Lü
Nature 588 (7837), 350–354, 2020
412020
Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
J Osei-Owusu, J Yang, KH Leung, Z Ruan, W Lü, Y Krishnan, Z Qiu
Cell reports 34 (4), 2021
382021
Hydrophobic core variations provide a structural framework for tyrosine kinase evolution and functional specialization
S Mohanty, K Oruganty, A Kwon, DP Byrne, S Ferries, Z Ruan, LE Hanold, ...
PLoS genetics 12 (2), e1005885, 2016
372016
Mechanistic insights into R776H mediated activation of epidermal growth factor receptor kinase
Z Ruan, N Kannan
Biochemistry 54 (27), 4216-4225, 2015
372015
Structures of TRPM5 channel elucidate mechanism of activation and inhibition
Z Ruan*, E Haley*, I Orozco*, R Roth, M Sabat, R Myers, J Du, W Lü
Nature Structural & Molecular Biology, 2021
282021
Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources
LC Huang, KE Ross, TR Baffi, H Drabkin, KJ Kochut, Z Ruan, ...
Scientific Reports 8, 6518, 2018
272018
LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena
YY Jiang, W Maier, R Baumeister, G Minevich, E Joachimiak, D Wloga, ...
PLoS Genetics 15 (7), 2019
232019
Emerging roles of the αC‐β4 loop in protein kinase structure, function, evolution, and disease
W Yeung*, Z Ruan*, N Kannan
IUBMB Life 72 (6), 1189-1202, 2020
222020
The Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate Tetrahymena
YY Jiang, W Maier, R Baumeister, G Minevich, E Joachimiak, Z Ruan, ...
Genetics 206 (2), 873-888, 2017
222017
Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tail
T Nguyen, Z Ruan, K Oruganty, N Kannan
PLoS One 10 (3), e0119636, 2015
212015
Coupled regulation by the juxtamembrane and sterile α motif (SAM) linker is a hallmark of Ephrin tyrosine kinase evolution
A Kwon, M John, Z Ruan, N Kannan
Journal of Biological Chemistry 293 (14), 5102-5116, 2018
192018
Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation
MD Fulton, LE Hanold, Z Ruan, S Patel, AM Beedle, N Kannan, ...
Bioorganic & Medicinal Chemistry 26 (6), 1167-1173, 2018
192018
Extensive non-canonical phosphorylation in human cells revealed using strong-anion exchange-mediated phosphoproteomics
G Hardman, S Perkins, Z Ruan, N Kannan, P Brownridge, DP Byrne, ...
bioRxiv, 2017
182017
Computational and experimental characterization of patient derived mutations reveal an unusual mode of regulatory spine assembly and drug sensitivity in EGFR kinase
Z Ruan, S Katiyar, N Kannan
Biochemistry 56 (1), 22-32, 2017
182017
Two Antagonistic Hippo Signaling Circuits Set the Division Plane at the Medial Position in the Ciliate Tetrahymena
YY Jiang*, W Maier*, R Baumeister, E Joachimiak, Z Ruan, N Kannan, ...
Genetics 211 (2), 651-663, 2019
152019
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Articles 1–20