| The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study MHJ Hagens, SSV Golla, B Janssen, DJ Vugts, W Beaino, AD Windhorst, ... European journal of nuclear medicine and molecular imaging 47, 379-389, 2020 | 54 | 2020 |
| Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X7 Receptor Antagonist SM Wilkinson, ML Barron, J O’Brien-Brown, B Janssen, L Stokes, ... ACS chemical neuroscience 8 (11), 2374-2380, 2017 | 42 | 2017 |
| Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists J O'Brien-Brown, A Jackson, TA Reekie, ML Barron, EL Werry, P Schiavini, ... European Journal of Medicinal Chemistry 130, 433-439, 2017 | 29 | 2017 |
| Structure–activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known … C Beinat, T Reekie, SD Banister, J O'Brien-Brown, T Xie, TT Olson, Y Xiao, ... European Journal of Medicinal Chemistry 95, 277-301, 2015 | 19 | 2015 |
| PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139 W Beaino, B Janssen, E Kooijman, R Vos, RC Schuit, J O’Brien-Brown, ... Journal of neuroinflammation 17, 1-18, 2020 | 18 | 2020 |
| Pharmacological evaluation of a novel series of urea, thiourea and guanidine derivatives as P2X7 receptor antagonists ECN Wong, TA Reekie, EL Werry, J O'Brien-Brown, SL Bowyer, ... Bioorganic & Medicinal Chemistry Letters 27 (11), 2439-2442, 2017 | 14 | 2017 |
| The novel P2X7 receptor antagonist PKT100 improves cardiac function and survival in pulmonary hypertension by direct targeting of the right ventricle T Hansen, K Karimi Galougahi, M Besnier, E Genetzakis, M Tsang, ... American Journal of Physiology-Heart and Circulatory Physiology 319 (1 …, 2020 | 13 | 2020 |
| The role of polycyclic frameworks in modulating P2X7 receptor function TB Callis, TA Reekie, J O'Brien-Brown, ECN Wong, EL Werry, N Elias, ... Tetrahedron 74 (12), 1207-1219, 2018 | 7 | 2018 |
| Recent advances in the development of sigma-1 receptor ligands M Manohar, SD Banister, C Beinat, J O'Brien-Brown, M Kassiou Australian Journal of Chemistry 68 (4), 600-609, 2015 | 7 | 2015 |
| Novel plasma protein binding analysis method for a PET tracer and its radiometabolites: A case study with [11C] SMW139 to explain the high uptake of radiometabolites in mouse brain R Aarnio, OM Alzghool, S Wahlroos, J O’Brien-Brown, M Kassiou, O Solin, ... Journal of Pharmaceutical and Biomedical Analysis 219, 114860, 2022 | 6 | 2022 |
| Pharmacological characterization of a structural hybrid P2X7R antagonist using ATP and LL-37 A Jackson, EL Werry, J O'Brien-Brown, P Schiavini, S Wilkinson, ... European Journal of Pharmacology 914, 174667, 2022 | 5 | 2022 |
| Novel P2X7 Receptor Ligands J O'Brien-Brown | 1 | 2019 |
| Adamantanyl-substituted benzamide compounds and their use as p2x7 receptor antagonists M Kassiou, G Figtree, J O'Brien-Brown, S Wilkinson, T Hansen | | 2020 |
| IL-1b release and pore formation induced by the human antimicrobial peptide LL-37 may be P2Y13 receptor-mediated ECN Wong, EL Werry, SM Wilkinson, J O'Brien-Brown, A Jackson, ... Proceedings for Annual Meeting of The Japanese Pharmacological Society …, 2018 | | 2018 |
| Pharmacological evaluation of novel bioisosteres of an adamantanyl benzamide P2X7 receptor antagonist M Barron, S Fuller, D Hibbs, M Kassiou, J O'Brien-Brown, J Ong, ... American Chemical Society, 2017 | | 2017 |
| Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists M Barron, A Jackson, M Kassiou, M McDonnell, L Munoz, J O'Brien-Brown, ... Elsevier Masson, 2017 | | 2017 |
| The P2X MHJ Hagens, SV Golla, B Janssen, DJ Vugts, W Beaino, AD Windhorst, ... Novel imaging markers for neuroinflammation in multiple sclerosis, 95, 0 | | |
