Paolo Arosio
Paolo Arosio
Assistant Professor, ETH Zurich
Verified email at chem.ethz.ch - Homepage
TitleCited byYear
On the lag phase in amyloid fibril formation
P Arosio, TPJ Knowles, S Linse
Physical Chemistry Chemical Physics 17, 7606-7618, 2015
3082015
Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology
G Wei, Z Su, NP Reynolds, P Arosio, IW Hamley, E Gazit, R Mezzenga
Chemical Society Reviews 46 (15), 4661-4708, 2017
2252017
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
SIA Cohen, P Arosio, J Presto, F Kurudenkandy, H Roshan Biverstal, ...
Nature structural & molecular biology 22 (3), 207-213, 2015
2182015
Molecular mechanisms of protein aggregation from global fitting of kinetic models.
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, ...
Nature Protocols 11 (2), 252-272, 2016
1992016
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation
N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, ...
Journal of the American Chemical Society 136 (10), 3859-3868, 2014
1492014
Chemical kinetics for drug discovery to combat protein aggregation diseases
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
Trends in pharmacological sciences 35 (3), 127-135, 2014
1322014
Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation
P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, ...
Nature communications 7, 10948, 2016
1002016
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, ...
Science advances 2 (2), e1501244, 2016
992016
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, ...
Proceedings of the National Academy of Sciences 114 (2), E200-E208, 2017
862017
Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay
P Arosio, R Cukalevski, B Frohm, TPJ Knowles, S Linse
Journal of the American Chemical Society 136 (1), 219-225, 2014
862014
Aggregation mechanism of an IgG2 and two IgG1 monoclonal antibodies at low pH: from oligomers to larger aggregates
P Arosio, S Rima, M Morbidelli
Pharmaceutical research 30 (3), 641-654, 2013
782013
The S/T-rich motif in the DNAJB6 chaperone delays polyglutamine aggregation and the onset of disease in a mouse model
V Kakkar, C Månsson, EP de Mattos, S Bergink, M van der Zwaag, ...
Molecular cell 62 (2), 272-283, 2016
682016
Aggregation stability of a monoclonal antibody during downstream processing
P Arosio, G Barolo, T Müller-Späth, H Wu, M Morbidelli
Pharmaceutical research 28 (8), 1884-1894, 2011
622011
Population balance modeling of antibodies aggregation kinetics
P Arosio, S Rima, M Lattuada, M Morbidelli
The Journal of Physical Chemistry B 116 (24), 7066-7075, 2012
592012
Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation
C Månsson, P Arosio, R Hussein, HH Kampinga, RM Hashem, ...
Journal of Biological Chemistry 289 (45), 31066-31076, 2014
552014
A new model of resorbable device degradation and drug release: Transient 1-dimension diffusional model
G Perale, P Arosio, D Moscatelli, V Barri, M Mueller, S Maccagnan, ...
Journal of Controlled Release 136, 196-205, 2009
532009
On the role of salt type and concentration on the stability behavior of a monoclonal antibody solution
P Arosio, B Jaquet, H Wu, M Morbidelli
Biophysical chemistry 168, 19-27, 2012
502012
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ...
Science advances 3 (6), e1700488, 2017
462017
End-to-end self-assembly of RADA 16-I nanofibrils in aqueous solutions
P Arosio, M Owczarz, H Wu, A Butté, M Morbidelli
Biophysical journal 102 (7), 1617-1626, 2012
422012
A multiscale view of therapeutic protein aggregation: a colloid science perspective
L Nicoud, M Owczarz, P Arosio, M Morbidelli
Biotechnology journal 10 (3), 367-378, 2015
382015
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