|General strategy for the generation of human antibody variable domains with increased aggregation resistance|
K Dudgeon, R Rouet, I Kokmeijer, P Schofield, J Stolp, D Langley, ...
Proceedings of the National Academy of Sciences 109 (27), 10879-10884, 2012
|Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity|
Z Sabouri, P Schofield, K Horikawa, E Spierings, D Kipling, KL Randall, ...
Proceedings of the National Academy of Sciences 111 (25), E2567-E2575, 2014
|I-motif DNA structures are formed in the nuclei of human cells|
M Zeraati, DB Langley, P Schofield, AL Moye, R Rouet, WE Hughes, ...
Nature chemistry 10 (6), 631-637, 2018
|The crystal structure of Pichia pastoris lysyl oxidase|
AP Duff, AE Cohen, PJ Ellis, JA Kuchar, DB Langley, EM Shepard, ...
Biochemistry 42 (51), 15148-15157, 2003
|Crystal structures of recombinant human purple acid phosphatase with and without an inhibitory conformation of the repression loop|
N Sträter, B Jasper, M Scholte, B Krebs, AP Duff, DB Langley, R Han, ...
Journal of molecular biology 351 (1), 233-246, 2005
|The structure of the KinA-Sda complex suggests an allosteric mechanism of histidine kinase inhibition|
AE Whitten, DA Jacques, B Hammouda, T Hanley, GF King, JM Guss, ...
Journal of molecular biology 368 (2), 407-420, 2007
|Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH|
KK Kumar, DA Jacques, G Pishchany, T Caradoc-Davies, T Spirig, ...
Journal of Biological Chemistry 286 (44), 38439-38447, 2011
|Using xenon as a probe for dioxygen-binding sites in copper amine oxidases|
AP Duff, DM Trambaiolo, AE Cohen, PJ Ellis, GA Juda, EM Shepard, ...
Journal of molecular biology 344 (3), 599-607, 2004
|Porphyrin-mediated cell surface heme capture from hemoglobin by Porphyromonas gingivalis|
M Paramaesvaran, KA Nguyen, E Caldon, JA McDonald, S Najdi, ...
Journal of bacteriology 185 (8), 2528-2537, 2003
|Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments|
CM Jeffries, MA Graewert, CE Blanchet, DB Langley, AE Whitten, ...
Nature protocols 11 (11), 2122, 2016
|Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein|
M Taraban, H Zhan, AE Whitten, DB Langley, KS Matthews, L Swint-Kruse, ...
Journal of molecular biology 376 (2), 466-481, 2008
|Expression of high-affinity human antibody fragments in bacteria|
R Rouet, D Lowe, K Dudgeon, B Roome, P Schofield, D Langley, ...
nature protocols 7 (2), 364, 2012
|Structure of N-acetyl-β-D-glucosaminidase (GcnA) from the endocarditis pathogen Streptococcus gordonii and its complex with the mechanism-based inhibitor NAG-thiazoline|
DB Langley, DWS Harty, NA Jacques, N Hunter, JM Guss, CA Collyer
Journal of molecular biology 377 (1), 104-116, 2008
|Protein–nucleoside contacts in the interaction between the replication terminator protein of Bacillus subtilis and the DNA terminator|
DB Langley, MT Smith, PJ Lewis, RG Wake
Molecular microbiology 10 (4), 771-779, 1993
|Feasibility of an HA2 domain-based periodontitis vaccine|
AA DeCarlo, Y Huang, CA Collyer, DB Langley, J Katz
Infection and immunity 71 (1), 562-566, 2003
|Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination|
DL Burnett, DB Langley, P Schofield, JR Hermes, TD Chan, J Jackson, ...
Science 360 (6385), 223-226, 2018
|Mechanism of inactivation of ornithine transcarbamoylase by N δ-(N′-sulfodiaminophosphinyl)-l-ornithine, a true transition state analogue? Crystal structure and implications …|
DB Langley, MD Templeton, BA Fields, RE Mitchell, CA Collyer
Journal of Biological Chemistry 275 (26), 20012-20019, 2000
|Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification|
MS Gadd, M Bhati, CM Jeffries, DB Langley, J Trewhella, JM Guss, ...
Journal of Biological Chemistry 286 (50), 42971-42980, 2011
|Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium (II) and rhenium (I) molecular wires|
SM Contakes, GA Juda, DB Langley, NW Halpern-Manners, AP Duff, ...
Proceedings of the National Academy of Sciences 102 (38), 13451-13456, 2005
|Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation|
KM O'Connell, DB Langley, EM Shepard, AP Duff, HB Jeon, G Sun, ...
Biochemistry 43 (34), 10965-10978, 2004