David Brent Langley
David Brent Langley
Verified email at garvan.org.au
TitleCited byYear
General strategy for the generation of human antibody variable domains with increased aggregation resistance
K Dudgeon, R Rouet, I Kokmeijer, P Schofield, J Stolp, D Langley, ...
Proceedings of the National Academy of Sciences 109 (27), 10879-10884, 2012
1322012
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity
Z Sabouri, P Schofield, K Horikawa, E Spierings, D Kipling, KL Randall, ...
Proceedings of the National Academy of Sciences 111 (25), E2567-E2575, 2014
1302014
I-motif DNA structures are formed in the nuclei of human cells
M Zeraati, DB Langley, P Schofield, AL Moye, R Rouet, WE Hughes, ...
Nature chemistry 10 (6), 631-637, 2018
1072018
The crystal structure of Pichia pastoris lysyl oxidase
AP Duff, AE Cohen, PJ Ellis, JA Kuchar, DB Langley, EM Shepard, ...
Biochemistry 42 (51), 15148-15157, 2003
1012003
Crystal structures of recombinant human purple acid phosphatase with and without an inhibitory conformation of the repression loop
N Sträter, B Jasper, M Scholte, B Krebs, AP Duff, DB Langley, R Han, ...
Journal of molecular biology 351 (1), 233-246, 2005
732005
The structure of the KinA-Sda complex suggests an allosteric mechanism of histidine kinase inhibition
AE Whitten, DA Jacques, B Hammouda, T Hanley, GF King, JM Guss, ...
Journal of molecular biology 368 (2), 407-420, 2007
672007
Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH
KK Kumar, DA Jacques, G Pishchany, T Caradoc-Davies, T Spirig, ...
Journal of Biological Chemistry 286 (44), 38439-38447, 2011
602011
Using xenon as a probe for dioxygen-binding sites in copper amine oxidases
AP Duff, DM Trambaiolo, AE Cohen, PJ Ellis, GA Juda, EM Shepard, ...
Journal of molecular biology 344 (3), 599-607, 2004
592004
Porphyrin-mediated cell surface heme capture from hemoglobin by Porphyromonas gingivalis
M Paramaesvaran, KA Nguyen, E Caldon, JA McDonald, S Najdi, ...
Journal of bacteriology 185 (8), 2528-2537, 2003
562003
Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments
CM Jeffries, MA Graewert, CE Blanchet, DB Langley, AE Whitten, ...
Nature protocols 11 (11), 2122, 2016
552016
Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein
M Taraban, H Zhan, AE Whitten, DB Langley, KS Matthews, L Swint-Kruse, ...
Journal of molecular biology 376 (2), 466-481, 2008
532008
Expression of high-affinity human antibody fragments in bacteria
R Rouet, D Lowe, K Dudgeon, B Roome, P Schofield, D Langley, ...
nature protocols 7 (2), 364, 2012
482012
Structure of N-acetyl-β-D-glucosaminidase (GcnA) from the endocarditis pathogen Streptococcus gordonii and its complex with the mechanism-based inhibitor NAG-thiazoline
DB Langley, DWS Harty, NA Jacques, N Hunter, JM Guss, CA Collyer
Journal of molecular biology 377 (1), 104-116, 2008
482008
Protein–nucleoside contacts in the interaction between the replication terminator protein of Bacillus subtilis and the DNA terminator
DB Langley, MT Smith, PJ Lewis, RG Wake
Molecular microbiology 10 (4), 771-779, 1993
431993
Feasibility of an HA2 domain-based periodontitis vaccine
AA DeCarlo, Y Huang, CA Collyer, DB Langley, J Katz
Infection and immunity 71 (1), 562-566, 2003
412003
Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination
DL Burnett, DB Langley, P Schofield, JR Hermes, TD Chan, J Jackson, ...
Science 360 (6385), 223-226, 2018
402018
Mechanism of inactivation of ornithine transcarbamoylase by N δ-(N′-sulfodiaminophosphinyl)-l-ornithine, a true transition state analogue? Crystal structure and implications …
DB Langley, MD Templeton, BA Fields, RE Mitchell, CA Collyer
Journal of Biological Chemistry 275 (26), 20012-20019, 2000
392000
Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification
MS Gadd, M Bhati, CM Jeffries, DB Langley, J Trewhella, JM Guss, ...
Journal of Biological Chemistry 286 (50), 42971-42980, 2011
362011
Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium (II) and rhenium (I) molecular wires
SM Contakes, GA Juda, DB Langley, NW Halpern-Manners, AP Duff, ...
Proceedings of the National Academy of Sciences 102 (38), 13451-13456, 2005
352005
Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation
KM O'Connell, DB Langley, EM Shepard, AP Duff, HB Jeon, G Sun, ...
Biochemistry 43 (34), 10965-10978, 2004
302004
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