| Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors WJL Wood, AW Patterson, H Tsuruoka, RK Jain, JA Ellman Journal of the American Chemical Society 127 (44), 15521-15527, 2005 | 137 | 2005 |
| Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold RK Jain, AD Hamilton Organic letters 2 (12), 1721-1723, 2000 | 134 | 2000 |
| Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors J Sun, D Wang, RK Jain, A Carie, S Paquette, E Ennis, MA Blaskovich, ... Oncogene 24 (29), 4701-4709, 2005 | 124 | 2005 |
| 1-Amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity K Miller-Moslin, S Peukert, RK Jain, MA McEwan, R Karki, L Llamas, ... Journal of medicinal chemistry 52 (13), 3954-3968, 2009 | 122 | 2009 |
| Englerin A agonizes the TRPC4/C5 cation channels to inhibit tumor cell line proliferation C Carson, P Raman, J Tullai, L Xu, M Henault, E Thomas, S Yeola, J Lao, ... PloS one 10 (6), e0127498, 2015 | 101 | 2015 |
| Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor J Sun, MA Blaskovich, RK Jain, F Delarue, D Paris, S Brem, ... Cancer research 64 (10), 3586-3592, 2004 | 90 | 2004 |
| Directed denaturation: room temperature and stoichiometric unfolding of cytochrome c by a metalloporphyrin dimer AJ Wilson, K Groves, RK Jain, HS Park, AD Hamilton Journal of the American Chemical Society 125 (15), 4420-4421, 2003 | 72 | 2003 |
| Structure–activity studies on a library of potent calix [4] arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation H Zhou, D Wang, L Baldini, E Ennis, R Jain, A Carie, SM Sebti, ... Organic & biomolecular chemistry 4 (12), 2376-2386, 2006 | 71 | 2006 |
| Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39 F Bassilana, A Carlson, JA DaSilva, B Grosshans, S Vidal, V Beck, ... Nature chemical biology 10 (5), 343-349, 2014 | 63 | 2014 |
| A porphyrin embedded in DNA K Berlin, RK Jain, MD Simon, C Richert The Journal of Organic Chemistry 63 (5), 1527-1535, 1998 | 61 | 1998 |
| Designing Protein Denaturants: Synthetic Agents Induce Cytochrome c Unfolding at Low Concentrations and Stoichiometries RK Jain, AD Hamilton Angewandte Chemie International Edition 41 (4), 641-643, 2002 | 59 | 2002 |
| Discovery of a ZIP7 inhibitor from a Notch pathway screen E Nolin, S Gans, L Llamas, S Bandyopadhyay, SM Brittain, ... Nature chemical biology 15 (2), 179-188, 2019 | 57 | 2019 |
| Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex JD Carelli, SG Sethofer, GA Smith, HR Miller, JL Simard, WC Merrick, ... Elife 4, e10222, 2015 | 53 | 2015 |
| Spectrometrically monitored selection experiments: quantitative laser desorption mass spectrometry of small chemical libraries K Berlin, RK Jain, C Tetzlaff, C Steinbeck, C Richert Chemistry & biology 4 (1), 63-77, 1997 | 52 | 1997 |
| D-Ala-D-Lac binding is not required for the high activity of vancomycin dimers against vancomycin resistant enterococci RK Jain, J Trias, JA Ellman Journal of the American Chemical Society 125 (29), 8740-8741, 2003 | 49 | 2003 |
| Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells C Russo, I Cornella-Taracido, L Galli-Stampino, R Jain, E Harrington, ... Blood, The Journal of the American Society of Hematology 117 (21), 5683-5691, 2011 | 48 | 2011 |
| Discovery of 2-pyridylpyrimidines as the first orally bioavailable GPR39 agonists S Peukert, R Hughes, J Nunez, G He, Z Yan, R Jain, L Llamas, ... ACS medicinal chemistry letters 5 (10), 1114-1118, 2014 | 47 | 2014 |
| Systematic chemogenetic library assembly SM Canham, Y Wang, A Cornett, DS Auld, DK Baeschlin, M Patoor, ... Cell Chemical Biology, 2020 | 42 | 2020 |
| Identification and structure–activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway S Peukert, RK Jain, A Geisser, Y Sun, R Zhang, A Bourret, A Carlson, ... Bioorganic & Medicinal Chemistry Letters 19 (2), 328-331, 2009 | 37 | 2009 |
| Affinity Classification of Kinase Inhibitors by Mass Spectrometric Methods and Validation Using Standard IC50 Measurements MC Jecklin, D Touboul, R Jain, EN Toole, J Tallarico, P Drueckes, ... Analytical chemistry 81 (1), 408-419, 2009 | 37 | 2009 |
