| Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog GD Li, DC Chiara, GW Sawyer, SS Husain, RW Olsen, JB Cohen Journal of Neuroscience 26 (45), 11599-11605, 2006 | 322 | 2006 |
| Specificity of Intersubunit General Anesthetic-binding Sites in the Transmembrane Domain of the Human α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor*♦ DC Chiara, SS Jayakar, X Zhou, X Zhang, PY Savechenkov, KS Bruzik, ... Journal of Biological Chemistry 288 (27), 19343-19357, 2013 | 145 | 2013 |
| Identification of Amino Acids Contributing to High and Low Affinity d-Tubocurarine Sites in the Torpedo Nicotinic Acetylcholine Receptor DC Chiara, JB Cohen Journal of Biological Chemistry 272 (52), 32940-32950, 1997 | 134 | 1997 |
| Multiple Propofol-binding Sites in a γ-Aminobutyric Acid Type A Receptor (GABAAR) Identified Using a Photoreactive Propofol Analog*♦ SS Jayakar, X Zhou, DC Chiara, Z Dostalova, PY Savechenkov, KS Bruzik, ... Journal of Biological Chemistry 289 (40), 27456-27468, 2014 | 122 | 2014 |
| Identification of nicotinic acetylcholine receptor amino acids photolabeled by the volatile anesthetic halothane DC Chiara, LJ Dangott, RG Eckenhoff, JB Cohen Biochemistry 42 (46), 13457-13467, 2003 | 117 | 2003 |
| Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [3H]TDBzl-etomidate, a photoreactive etomidate analogue DC Chiara, Z Dostalova, SS Jayakar, X Zhou, KW Miller, JB Cohen Biochemistry 51 (4), 836-847, 2012 | 113 | 2012 |
| Numerous classes of general anesthetics inhibit etomidate binding to γ-aminobutyric acid type A (GABAA) receptors GD Li, DC Chiara, JB Cohen, RW Olsen Journal of biological chemistry 285 (12), 8615-8620, 2010 | 89 | 2010 |
| Cholesterol interacts with transmembrane α-helices M1, M3, and M4 of the Torpedo nicotinic acetylcholine receptor: photolabeling studies using [3H]azicholesterol AK Hamouda, DC Chiara, D Sauls, JB Cohen, MP Blanton Biochemistry 45 (3), 976-986, 2006 | 88 | 2006 |
| Neurosteroids allosterically modulate binding of the anesthetic etomidate to γ-aminobutyric acid type A receptors GD Li, DC Chiara, JB Cohen, RW Olsen Journal of Biological Chemistry 284 (18), 11771-11775, 2009 | 87 | 2009 |
| Structure of the agonist-binding sites of the Torpedo nicotinic acetylcholine receptor: affinity-labeling and mutational analyses identify γTyr-111/δArg-113 as antagonist … DC Chiara, Y Xie, JB Cohen Biochemistry 38 (20), 6689-6698, 1999 | 86 | 1999 |
| Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector S Nirthanan, G Garcia, DC Chiara, SS Husain, JB Cohen Journal of biological chemistry 283 (32), 22051-22062, 2008 | 74 | 2008 |
| Identification of tryptophan 55 as the primary site of [3H]nicotine photoincorporation in the γ-subunit of the Torpedo nicotinic acetylcholine receptor DC Chiara, RE Middleton, JB Cohen FEBS letters 423 (2), 223-226, 1998 | 72 | 1998 |
| Identification of the bovine γ-aminobutyric acid type A receptor α subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513 GW Sawyer, DC Chiara, RW Olsen, JB Cohen Journal of Biological Chemistry 277 (51), 50036-50045, 2002 | 65 | 2002 |
| p-(4-Azipentyl)propofol: A Potent Photoreactive General Anesthetic Derivative of Propofol DS Stewart, PY Savechenkov, Z Dostalova, DC Chiara, R Ge, DE Raines, ... Journal of medicinal chemistry 54 (23), 8124-8135, 2011 | 51 | 2011 |
| Gating-enhanced Accessibility of Hydrophobic Sites within the Transmembrane Region of the Nicotinic Acetylcholine Receptor's δ-Subunit. A TIME-RESOLVED PHOTOLABELING STUDY E Arevalo, DC Chiara, SA Forman, JB Cohen, KW Miller Journal of Biological Chemistry 280 (14), 13631-13640, 2005 | 50 | 2005 |
| Photoaffinity labeling the propofol binding site in GLIC DC Chiara, Q Chen, T Tillman, JF Gill, WP Dailey, RG Eckenhoff, Y Xu, ... Biophysical Journal 104 (2), 636a, 2013 | 49 | 2013 |
| Allyl m-Trifluoromethyldiazirine Mephobarbital: An Unusually Potent Enantioselective and Photoreactive Barbiturate General Anesthetic PY Savechenkov, X Zhang, DC Chiara, DS Stewart, R Ge, X Zhou, ... Journal of medicinal chemistry 55 (14), 6554-6565, 2012 | 48 | 2012 |
| Probing the structure of the nicotinic acetylcholine receptor with 4-benzoylbenzoylcholine, a novel photoaffinity competitive antagonist D Wang, DC Chiara, Y Xie, JB Cohen Journal of Biological Chemistry 275 (37), 28666-28674, 2000 | 45 | 2000 |
| Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors SA Forman, DC Chiara, KW Miller Neuropharmacology 96, 169-177, 2015 | 44 | 2015 |
| Conformational changes in the nicotinic acetylcholine receptor during gating and desensitization IH Yamodo, DC Chiara, JB Cohen, KW Miller Biochemistry 49 (1), 156-165, 2010 | 43 | 2010 |
Jonathan B. CohenHarvard Medical SchoolVerified email at hms.harvard.edu
