Celine Valant
Celine Valant
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Activation and allosteric modulation of a muscarinic acetylcholine receptor
AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H Hübner, E Pardon, ...
Nature 504 (7478), 101-106, 2013
The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors
SPH Alexander, A Christopoulos, AP Davenport, E Kelly, A Mathie, ...
British journal of pharmacology 178, S27-S156, 2021
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
RO Dror, HF Green, C Valant, DW Borhani, JR Valcourt, AC Pan, ...
Nature 503 (7475), 295-299, 2013
Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner …
C Koole, D Wootten, J Simms, C Valant, R Sridhar, OL Woodman, ...
Molecular pharmacology 78 (3), 456-465, 2010
A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity: MUSCARINIC PARTIAL AGONIST McN-A-343 AS A BITOPIC ORTHOSTERIC/ALLOSTERIC LIGAND∗
C Valant, KJ Gregory, NE Hall, PJ Scammells, MJ Lew, PM Sexton, ...
Journal of Biological Chemistry 283 (43), 29312-29321, 2008
The best of both worlds? Bitopic orthosteric/allosteric ligands of G protein–coupled receptors
C Valant, J Robert Lane, PM Sexton, A Christopoulos
Annual review of pharmacology and toxicology 52 (1), 153-178, 2012
Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor
AE Davey, K Leach, C Valant, AD Conigrave, PM Sexton, A Christopoulos
Endocrinology 153 (3), 1232-1241, 2012
Endogenous allosteric modulators of G protein–coupled receptors
ET van der Westhuizen, C Valant, PM Sexton, A Christopoulos
Journal of Pharmacology and Experimental Therapeutics 353 (2), 246-260, 2015
Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects
C Valant, CC Felder, PM Sexton, A Christopoulos
Molecular pharmacology 81 (1), 41-52, 2012
Allosteric Modulators of the Adenosine A1 Receptor: Synthesis and Pharmacological Evaluation of 4-Substituted 2-Amino-3-benzoylthiophenes
L Aurelio, C Valant, BL Flynn, PM Sexton, A Christopoulos, PJ Scammells
Journal of medicinal chemistry 52 (14), 4543-4547, 2009
Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist
C Valant, LT May, L Aurelio, CH Chuo, PJ White, JA Baltos, PM Sexton, ...
Proceedings of the National Academy of Sciences 111 (12), 4614-4619, 2014
Orthosteric/allosteric bitopic ligands
C Valant, PM Sexton, A Christopoulos
Molecular interventions 9 (3), 125, 2009
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
CJ Draper-Joyce, R Bhola, J Wang, A Bhattarai, ATN Nguyen, ...
Nature 597 (7877), 571-576, 2021
Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation
C Koole, D Wootten, J Simms, C Valant, LJ Miller, A Christopoulos, ...
Molecular pharmacology 80 (3), 486-497, 2011
A novel, conformation‐specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties
EL Maillet, N Pellegrini, C Valant, B Bucher, M Hibert, JJ Bourguignon, ...
The FASEB Journal 21 (9), 2124-2134, 2007
Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor
Y Miao, DA Goldfeld, EV Moo, PM Sexton, A Christopoulos, ...
Proceedings of the National Academy of Sciences 113 (38), E5675-E5684, 2016
Allosteric modulation of endogenous metabolites as an avenue for drug discovery
D Wootten, EE Savage, C Valant, LT May, KW Sloop, J Ficorilli, ...
Molecular pharmacology 82 (2), 281-290, 2012
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
SPH Alexander, A Christopoulos, AP Davenport, E Kelly, AA Mathie, ...
British Journal of Pharmacology 180, S23-S144, 2023
Synthesis and Pharmacological Profiling of Analogues of Benzyl Quinolone Carboxylic Acid (BQCA) as Allosteric Modulators of the M1 Muscarinic Receptor
SN Mistry, C Valant, PM Sexton, B Capuano, A Christopoulos, ...
Journal of medicinal chemistry 56 (12), 5151-5172, 2013
Crystal structure of the M5 muscarinic acetylcholine receptor
Z Vuckovic, PR Gentry, AE Berizzi, K Hirata, S Varghese, G Thompson, ...
Proceedings of the National Academy of Sciences 116 (51), 26001-26007, 2019
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