| PPARγ in complex with an antagonist and inverse agonist: a tumble and trap mechanism of the activation helix RL Frkic, AC Marshall, AL Blayo, TL Pukala, TM Kamenecka, PR Griffin, ... IScience 5, 69-79, 2018 | 43* | 2018 |
| The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes RL Frkic, K Richter, JB Bruning Journal of Biological Chemistry 297 (3), 2021 | 40 | 2021 |
| Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones PA Elzahhar, R Alaaeddine, TM Ibrahim, R Nassra, A Ismail, BSK Chua, ... European journal of medicinal chemistry 167, 562-582, 2019 | 39 | 2019 |
| Antiviral cyclic peptides targeting the main protease of SARS-CoV-2 J Johansen-Leete, S Ullrich, SE Fry, R Frkic, MJ Bedding, A Aggarwal, ... Chemical science 13 (13), 3826-3836, 2022 | 36 | 2022 |
| Structure–Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics RL Frkic, Y He, BB Rodriguez, MR Chang, D Kuruvilla, A Ciesla, AD Abell, ... Journal of medicinal chemistry 60 (11), 4584-4593, 2017 | 29 | 2017 |
| Through-Space Scalar 19F–19F Couplings between Fluorinated Noncanonical Amino Acids for the Detection of Specific Contacts in Proteins HW Orton, H Qianzhu, EH Abdelkader, EI Habel, YJ Tan, RL Frkic, ... Journal of the American Chemical Society 143 (46), 19587-19598, 2021 | 23 | 2021 |
| Genetic Encoding of Cyanopyridylalanine for In‐Cell Protein Macrocyclization by the Nitrile–Aminothiol Click Reaction EH Abdelkader, H Qianzhu, J George, RL Frkic, CJ Jackson, C Nitsche, ... Angewandte Chemie 134 (13), e202114154, 2022 | 22 | 2022 |
| Unique polypharmacology nuclear receptor modulator blocks inflammatory signaling pathways MR Chang, A Ciesla, TS Strutzenberg, SJ Novick, Y He, ... ACS Chemical Biology 14 (5), 1051-1062, 2019 | 9 | 2019 |
| Structural and dynamic elucidation of a non-acid PPARγ partial agonist: SR1988 RL Frkic, BS Chua, Y Shin, BD Pascal, SJ Novick, TM Kamenecka, ... Nuclear receptor research 5, 2018 | 6 | 2018 |
| Asymmetric Ene-Reduction of α,β-Unsaturated Compounds by F420-Dependent Oxidoreductases A Enzymes from Mycobacterium smegmatis SW Kang, J Antoney, RL Frkic, DW Lupton, R Speight, C Scott, ... Biochemistry 62 (3), 873-891, 2022 | 4 | 2022 |
| Obtaining crystals of PPARγ ligand binding domain bound to small molecules RL Frkic, JB Bruning Nuclear Receptors: Methods and Experimental Protocols, 253-260, 2019 | 3 | 2019 |
| PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles RL Frkic, JL Pederick, AJ Horsfall, B Jovcevski, EE Crame, W Kowalczyk, ... ACS Chemical Biology 18 (5), 1115-1123, 2023 | 2 | 2023 |
| Mononuclear binding and catalytic activity of europium (III) and gadolinium (III) at the active site of the model metalloenzyme phosphotriesterase CW Breeze, Y Nakano, EC Campbell, RL Frkic, DW Lupton, CJ Jackson Acta Crystallographica Section D: Structural Biology 80 (4), 2024 | | 2024 |
| A structural basis for the activation of peroxisome proliferator-activated receptor gamma (PPARγ) by perfluorooctanoic acid (PFOA) JL Pederick, RL Frkic, DP McDougal, JB Bruning Chemosphere 354, 141723, 2024 | | 2024 |
| Identification and Characterization of a Bacterial Periplasmic Solute Binding Protein That Binds l-Amino Acid Amides OB Smith, RL Frkic, MG Rahman, CJ Jackson, JA Kaczmarski Biochemistry, 2024 | | 2024 |
| Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape V Vongsouthi, R Georgelin, D Matthews, J Saunders, BM Lee, J Ton, ... bioRxiv, 2024.04. 25.591214, 2024 | | 2024 |
| Discovery of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 via mRNA Display (preprint) J Johansen-Leete, S Ullrich, S Fry, R Frkic, M Bedding, A Aggarwal, ... | | 2021 |
| Understanding PPARg-Ligand Interactions to Treat Type 2 Diabetes RL Frkic | | 2021 |
| Supporting information Through-Space Scalar 19F–19F Couplings between Fluorinated Non-Canonical Amino Acids for the Detection of Specific Contacts in Proteins HW Orton, H Qianzhu, EH Abdelkader, EI Habel, YJ Tan, RL Frkic, ... | | |
John B. BruningAssociate Professor, University of AdelaideVerified email at adelaide.edu.au
