| Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth D Drygin, A Lin, J Bliesath, CB Ho, SE O'Brien, C Proffitt, M Omori, ... Cancer research 71 (4), 1418-1430, 2011 | 654 | 2011 |
| Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53 MJ Bywater, G Poortinga, E Sanij, N Hein, A Peck, C Cullinane, M Wall, ... Cancer cell 22 (1), 51-65, 2012 | 602 | 2012 |
| mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar … KM Hannan, Y Brandenburger, A Jenkins, K Sharkey, A Cavanaugh, ... Molecular and cellular biology, 2003 | 591 | 2003 |
| The renin–angiotensin system and cancer: old dog, new tricks AJ George, WG Thomas, RD Hannan Nature Reviews Cancer 10 (11), 745-759, 2010 | 584 | 2010 |
| ATRX interacts with H3. 3 in maintaining telomere structural integrity in pluripotent embryonic stem cells LH Wong, JD McGhie, M Sim, MA Anderson, S Ahn, RD Hannan, ... Genome research 20 (3), 351-360, 2010 | 462 | 2010 |
| Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere LH Wong, KH Brettingham-Moore, L Chan, JM Quach, MA Anderson, ... Genome research 17 (8), 1146-1160, 2007 | 348 | 2007 |
| An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF VY Stefanovsky, G Pelletier, R Hannan, T Gagnon-Kugler, LI Rothblum, ... Molecular cell 8 (5), 1063-1073, 2001 | 321 | 2001 |
| Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function K Jastrzebski, KM Hannan, EB Tchoubrieva, RD Hannan, RB Pearson Growth factors 25 (4), 209-226, 2007 | 319 | 2007 |
| Direct actions of urotensin II on the heart: implications for cardiac fibrosis and hypertrophy A Tzanidis, RD Hannan, WG Thomas, D Onan, DJ Autelitano, F See, ... Circulation research 93 (3), 246-253, 2003 | 315 | 2003 |
| AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, ... Oncogene 31 (15), 1949-1962, 2012 | 298 | 2012 |
| The nucleolus: an emerging target for cancer therapy N Hein, KM Hannan, AJ George, E Sanij, RD Hannan Trends in molecular medicine 19 (11), 643-654, 2013 | 286 | 2013 |
| Cardiac hypertrophy: a matter of translation RD Hannan, A Jenkins, AK Jenkins, Y Brandenburger Clinical and Experimental Pharmacology and Physiology 30 (8), 517-527, 2003 | 285 | 2003 |
| Targeting the nucleolus for cancer intervention JE Quin, JR Devlin, D Cameron, KM Hannan, RB Pearson, RD Hannan Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (6), 802-816, 2014 | 284 | 2014 |
| UBF levels determine the number of active ribosomal RNA genes in mammals E Sanij, G Poortinga, K Sharkey, S Hung, TP Holloway, J Quin, E Robb, ... The Journal of cell biology 183 (7), 1259-1274, 2008 | 263 | 2008 |
| Dysregulation of the basal RNA polymerase transcription apparatus in cancer MJ Bywater, RB Pearson, GA McArthur, RD Hannan Nature Reviews Cancer 13 (5), 299-314, 2013 | 254 | 2013 |
| Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor WG Thomas, Y Brandenburger, DJ Autelitano, T Pham, H Qian, ... Circulation research 90 (2), 135-142, 2002 | 226 | 2002 |
| MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation G Poortinga, KM Hannan, H Snelling, CR Walkley, A Jenkins, K Sharkey, ... The EMBO journal 23 (16), 3325-3335, 2004 | 219 | 2004 |
| A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling YC Chen, AV Bui, J Diesch, R Manasseh, C Hausding, J Rivera, I Haviv, ... Circulation research 113 (3), 252-265, 2013 | 215 | 2013 |
| Second AKT: the rise of SGK in cancer signalling MA Bruhn, RB Pearson, RD Hannan, KE Sheppard Growth factors 28 (6), 394-408, 2010 | 200 | 2010 |
| First-in-human RNA polymerase I transcription inhibitor CX-5461 in patients with advanced hematologic cancers: results of a phase I dose-escalation study A Khot, N Brajanovski, DP Cameron, N Hein, KH Maclachlan, E Sanij, ... Cancer discovery 9 (8), 1036-1049, 2019 | 189 | 2019 |
Rick PearsonGroup Leader, Peter MacCallum Cancer CentreVerified email at petermac.org
