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Denis M Grant
Denis M Grant
Professor of Pharmacology & Toxicology, University of Toronto
Verified email at utoronto.ca
Title
Cited by
Cited by
Year
Human Arylamine N-Acetyltransferase Genes: Isolation, Chromosomal Localization, and Functional Expression
M Blum, DM Grant, W McBride, M Heim, UA Meyer
DNA and cell biology 9 (3), 193-203, 1990
5751990
Nomenclature for N-acetyltransferases
KP Vatsis, WW Weber, DA Bell, JM Dupret, DAP Evans, DM Grant, ...
Pharmacogenetics and Genomics 5 (1), 1-17, 1995
5101995
Molecular mechanism of slow acetylation of drugs and carcinogens in humans.
M Blum, A Demierre, DM Grant, M Heim, UA Meyer
Proceedings of the National Academy of Sciences 88 (12), 5237-5241, 1991
4891991
Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity
NH Shear, SP Spielberg, DM Grant, BK Tang, W KALOW
Annals of Internal Medicine 105 (2), 179-184, 1986
4561986
Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases
DW Hein, MA Doll, TD Rustan, K Gray, Y Feng, RJ Ferguson, DM Grant
Carcinogenesis 14 (8), 1633-1638, 1993
4281993
Variability in caffeine metabolism
DM Grant, BK Tang, W Kalow
Clinical Pharmacology & Therapeutics 33 (5), 591-602, 1983
3491983
Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes.
DM Grant, M Blum, M Beer, UA Meyer
Molecular pharmacology 39 (2), 184-191, 1991
3371991
Human acetyltransferase polymorphisms
DM Grant, NC Hughes, SA Janezic, GH Goodfellow, HJ Chen, A Gaedigk, ...
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 376 (1 …, 1997
3261997
Biotransformation of caffeine, paraxanthine, theophylline, and theobromine by polycyclic aromatic hydrocarbon-inducible cytochrome (s) P-450 in human liver microsomes.
ME Campbell, DM Grant, T Inaba, W Kalow
Drug Metabolism and Disposition 15 (2), 237-249, 1987
2791987
A simple test for acetylator phenotype using caffeine.
DM Grant, BK Tang, W Kalow
British journal of clinical pharmacology 17 (4), 459-464, 1984
2591984
Detoxification pathways in the liver
DM Grant
Journal of inherited metabolic disease 14, 421-430, 1991
2371991
Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes
S Ogawa, J Surapisitchat, C Virtanen, M Ogawa, M Niapour, KS Sugamori, ...
Development 140 (15), 3285-3296, 2013
1872013
Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver.
DM Grant, K Mörike, M Eichelbaum, UA Meyer
The Journal of clinical investigation 85 (3), 968-972, 1990
1751990
Localization of N-Acetyltransferases NAT1 and NAT2 in Human Tissues
KF Windmill, A Gaedigk, P de la M. Hall, H Samaratunga, DM Grant, ...
Toxicological Sciences 54 (1), 19-29, 2000
1712000
Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions
A Gaedigk, SP Spielberg, DM Grant
Pharmacogenetics and Genomics 4 (3), 142-153, 1994
1661994
The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies
KF Windmill, RA McKinnon, X Zhu, A Gaedigk, DM Grant, ME McManus
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 376 (1 …, 1997
1651997
Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism …
JM Dupret, DM Grant
Journal of Biological Chemistry 267 (11), 7381-7385, 1992
1571992
Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe
NC Hughes, SA Janezic, KL McQueen, MAS Jewett, T Castranio, DA Bell, ...
Pharmacogenetics and Genomics 8 (1), 55-66, 1998
1561998
Molecular genetics of the N-acetyltransferases
DM Grant
Pharmacogenetics and Genomics 3 (1), 45-50, 1993
1561993
Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations
U Fuhr, KL Rost, R Engelhardt, M Sachs, D Liermann, C Belloc, P Beaune, ...
Pharmacogenetics and Genomics 6 (2), 159-176, 1996
1521996
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