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J. Willem M. Nissink
J. Willem M. Nissink
senior principal scientist
Verified email at artios.com
Title
Cited by
Cited by
Year
Highly stable Si− C linked functionalized monolayers on the silicon (100) surface
AB Sieval, AL Demirel, JWM Nissink, MR Linford, JH Van der Maas, ...
Langmuir 14 (7), 1759-1768, 1998
701*1998
A new test set for validating predictions of protein–ligand interaction
JWM Nissink, C Murray, M Hartshorn, ML Verdonk, JC Cole, R Taylor
Proteins: structure, function, and bioinformatics 49 (4), 457-471, 2002
5462002
Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017 Utility and Limitations
JB Baell, JWM Nissink
ACS chemical biology 13 (1), 36-44, 2018
5392018
Modeling water molecules in protein− ligand docking using GOLD
ML Verdonk, G Chessari, JC Cole, MJ Hartshorn, CW Murray, ...
Journal of medicinal chemistry 48 (20), 6504-6515, 2005
4662005
Comparing protein–ligand docking programs is difficult
JC Cole, CW Murray, JWM Nissink, RD Taylor, R Taylor
Proteins: Structure, Function, and Bioinformatics 60 (3), 325-332, 2005
4202005
PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS
JL Dahlin, JWM Nissink, JM Strasser, S Francis, LA Higgins, H Zhou, ...
Journal of medicinal chemistry 58 (5), 2091-2113, 2015
3532015
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein …
KM Foote, K Blades, A Cronin, S Fillery, SS Guichard, L Hassall, I Hickson, ...
Journal of medicinal chemistry 56 (5), 2125-2138, 2013
2412013
Discovery and characterization of AZD6738, a potent inhibitor of ataxia telangiectasia mutated and Rad3 related (ATR) kinase with application as an anticancer agent
KM Foote, JWM Nissink, T McGuire, P Turner, S Guichard, JWT Yates, ...
Journal of medicinal chemistry 61 (22), 9889-9907, 2018
2292018
Virtual screening in drug discovery
J Alvarez, B Shoichet
CRC press, 2005
1892005
Potent and selective inhibitors of MTH1 probe its role in cancer cell survival
JG Kettle, H Alwan, M Bista, J Breed, NL Davies, K Eckersley, S Fillery, ...
Journal of medicinal chemistry 59 (6), 2346-2361, 2016
1522016
Protein-ligand docking and virtual screening with GOLD
JC Cole, JWM Nissink, R Taylor
Virtual screening in drug discovery 1, 379-415, 2005
1152005
Simple size-independent measure of ligand efficiency
JWM Nissink
Journal of chemical information and modeling 49 (6), 1617-1622, 2009
1132009
Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold
SM Devine, MD Mulcair, CO Debono, EWW Leung, JWM Nissink, SS Lim, ...
Journal of medicinal chemistry 58 (3), 1205-1214, 2015
912015
(Thio) urea resorcinarene cavitands. Complexation and membrane transport of halide anions
H Boerrigter, L Grave, JWM Nissink, LAJ Chrisstoffels, JH van der Maas, ...
The Journal of Organic Chemistry 63 (13), 4174-4180, 1998
851998
Mimicry by asx‐and ST‐turns of the four main types of β‐turn in proteins
WJ Duddy, JWM Nissink, FH Allen, EJ Milner‐White
Protein Science 13 (11), 3051-3055, 2004
722004
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
JC Exell, MJ Thompson, LD Finger, SJ Shaw, J Debreczeni, TA Ward, ...
Nature chemical biology 12 (10), 815-821, 2016
672016
Discovery of AZD9833, a potent and orally bioavailable selective estrogen receptor degrader and antagonist
JS Scott, TA Moss, A Balazs, B Barlaam, J Breed, RJ Carbajo, ...
Journal of Medicinal Chemistry 63 (23), 14530-14559, 2020
652020
Quantification of frequent-hitter behavior based on historical high-throughput screening data
JW M Nissink, S Blackburn
Future Medicinal Chemistry 6 (10), 1113-1126, 2014
592014
Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives
JA Tucker, N Bennett, C Brassington, ST Durant, G Hassall, G Holdgate, ...
PloS one 7 (12), e50889, 2012
582012
Increasing the delivery of next generation therapeutics from high throughput screening libraries
MJ Wigglesworth, DC Murray, CJ Blackett, M Kossenjans, JWM Nissink
Current Opinion in Chemical Biology 26, 104-110, 2015
552015
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