| A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Y Matsumura, H Maeda Cancer research 46 (12_Part_1), 6387-6392, 1986 | 8957 | 1986 |
| Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review H Maeda, J Wu, T Sawa, Y Matsumura, K Hori Journal of controlled release 65 (1-2), 271-284, 2000 | 7660 | 2000 |
| The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect J Fang, H Nakamura, H Maeda Advanced drug delivery reviews 63 (3), 136-151, 2011 | 3841 | 2011 |
| The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting H Maeda Advances in enzyme regulation 41 (1), 189-207, 2001 | 3002 | 2001 |
| The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo H Maeda, H Nakamura, J Fang Advanced drug delivery reviews 65 (1), 71-79, 2013 | 2357 | 2013 |
| Exploiting the enhanced permeability and retention effect for tumor targeting AK Iyer, G Khaled, J Fang, H Maeda Drug discovery today 11 (17-18), 812-818, 2006 | 2225 | 2006 |
| Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology U Prabhakar, H Maeda, RK Jain, EM Sevick-Muraca, W Zamboni, ... Cancer research 73 (8), 2412-2417, 2013 | 1563 | 2013 |
| Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect H Maeda, GY Bharate, J Daruwalla European journal of pharmaceutics and biopharmaceutics 71 (3), 409-419, 2009 | 1442 | 2009 |
| Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects H Maeda Bioconjugate chemistry 21 (5), 797-802, 2010 | 1165 | 2010 |
| Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS H Maeda, T Sawa, T Konno Journal of controlled release 74 (1-3), 47-61, 2001 | 1151 | 2001 |
| Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity H Maeda Advanced drug delivery reviews 91, 3-6, 2015 | 1113 | 2015 |
| Tumoritropic and lymphotropic principles of macromolecular drugs. H Maeda, Y Matsumura Critical reviews in therapeutic drug carrier systems 6 (3), 193-210, 1989 | 890 | 1989 |
| Macromolecular therapeutics in cancer treatment: the EPR effect and beyond H Maeda Journal of Controlled Release 164 (2), 138-144, 2012 | 878 | 2012 |
| Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo H Maeda, LW Seymour, Y Miyamoto Bioconjugate chemistry 3 (5), 351-362, 1992 | 747 | 1992 |
| Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications H Maeda, J Fang, T Inutsuka, Y Kitamoto International immunopharmacology 3 (3), 319-328, 2003 | 691 | 2003 |
| Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/. bul. NO (nitric oxide) through a radical reaction T Akaike, M Yoshida, Y Miyamoto, K Sato, M Kohno, K Sasamoto, ... Biochemistry 32 (3), 827-832, 1993 | 679 | 1993 |
| SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy H Maeda Advanced drug delivery reviews 46 (1-3), 169-185, 2001 | 661 | 2001 |
| Nitric oxide and oxygen radicals in infection, inflammation, and cancer H Maeda, T Akaike BIOCHEMISTRY C/C OF BIOKHIMIIA 63, 854-865, 1998 | 657 | 1998 |
| Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. T Akaike, Y Noguchi, S Ijiri, K Setoguchi, M Suga, YM Zheng, ... Proceedings of the National Academy of Sciences 93 (6), 2448-2453, 1996 | 623 | 1996 |
| Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues Y Noguchi, J Wu, R Duncan, J Strohalm, K Ulbrich, T Akaike, H Maeda Japanese Journal of Cancer Research 89 (3), 307-314, 1998 | 613 | 1998 |
