|Irinotecan-Induced Gastrointestinal Dysfunction and Pain Are Mediated by Common TLR4-Dependent MechanismsTLR4 and Chemotherapy-Induced Toxicity|
HR Wardill, RJ Gibson, YZA Van Sebille, KR Secombe, JK Coller, ...
Molecular cancer therapeutics 15 (6), 1376-1386, 2016
|Adjunctive fecal microbiota transplantation in supportive oncology: Emerging indications and considerations in immunocompromised patients|
HR Wardill, KR Secombe, RV Bryant, MD Hazenberg, SP Costello
EBioMedicine 44, 730-740, 2019
|TLR4-Dependent Claudin-1 Internalization and Secretagogue-Mediated Chloride Secretion Regulate Irinotecan-Induced DiarrheaTLR4-Dependent Tight Junction Regulation|
HR Wardill, JM Bowen, YZA Van Sebille, KR Secombe, JK Coller, IA Ball, ...
Molecular Cancer Therapeutics 15 (11), 2767-2779, 2016
|The bidirectional interaction of the gut microbiome and the innate immune system: Implications for chemotherapy‐induced gastrointestinal toxicity|
KR Secombe, JK Coller, RJ Gibson, HR Wardill, JM Bowen
International journal of cancer 144 (10), 2365-2376, 2019
|Dacomitinib‐induced diarrhoea is associated with altered gastrointestinal permeability and disruption in ileal histology in rats|
YZA Van Sebille, RJ Gibson, HR Wardill, KR Secombe, IA Ball, ...
International Journal of Cancer 140 (12), 2820-2829, 2017
|Diarrhea induced by small molecule tyrosine kinase inhibitors compared with chemotherapy: potential role of the microbiome|
KR Secombe, YZA Van Sebille, BJ Mayo, JK Coller, RJ Gibson, ...
Integrative Cancer Therapies 19, 1534735420928493, 2020
|Targeting neratinib-induced diarrhea with budesonide and colesevelam in a rat model|
KR Secombe, IA Ball, J Shirren, AD Wignall, J Finnie, D Keefe, ...
Cancer chemotherapy and pharmacology 83 (3), 531-543, 2019
|Guidelines for reporting on animal fecal transplantation (GRAFT) studies: recommendations from a systematic review of murine transplantation protocols|
KR Secombe, GH Al-Qadami, CB Subramaniam, JM Bowen, J Scott, ...
Gut microbes 13 (1), 1979878, 2021
|Potential safety concerns of TLR4 antagonism with irinotecan: a preclinical observational report|
JK Coller, JM Bowen, IA Ball, HR Wardill, YZA van Sebille, ...
Cancer chemotherapy and pharmacology 79 (2), 431-434, 2017
|A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options|
HR Wardill, RJ Gibson, YZA Van Sebille, KR Secombe, RM Logan, ...
Experimental Biology and Medicine 241 (13), 1386-1394, 2016
|The GLP-2 analogue elsiglutide reduces diarrhoea caused by the tyrosine kinase inhibitor lapatinib in rats|
BJ Mayo, KR Secombe, AD Wignall, E Bateman, D Thorpe, C Pietra, ...
Cancer chemotherapy and pharmacology 85 (4), 793-803, 2020
|Budesonide reduces neratinib-induced gastrointestinal injury and diarrhoea in rats|
KR Secombe, IA Ball, J Shirren, AD Wignall, HR Wardill, YZA Van Sebille, ...
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY 13, 74-74, 2017
|Pathophysiology of neratinib-induced diarrhea in male and female rats: microbial alterations a potential determinant|
KR Secombe, IA Ball, J Shirren, AD Wignall, DM Keefe, JM Bowen
Breast Cancer 28 (1), 99-109, 2021
|Pre-treatment Blautia abundance regulates chemotherapy-induced gastrointestinal toxicity risk: a pilot study|
K Secombe, J Bowen, J Coller, R Gibson, A Stringer, N Al-Dasooqi, ...
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY 14, 59-59, 2018
|Epithelial-specific TLR4 knockout challenges current evidence of TLR4 homeostatic control of gut permeability|
EE Crame, JM Bowen, KR Secombe, JK Coller, M François, W Leifert, ...
Inflammatory Intestinal Diseases 6 (4), 199-209, 2021
|Baseline gut microbiota composition is associated with oral mucositis and tumour recurrence in patients with head and neck cancer: a pilot study|
G Al-Qadami, J Bowen, Y Van Sebille, K Secombe, M Dorraki, J Verjans, ...
|Antibiotic treatment targeting gram negative bacteria prevents neratinib-induced diarrhea in rats|
KR Secombe, IA Ball, AD Wignall, E Bateman, DM Keefe, JM Bowen
Neoplasia 30, 100806, 2022
|Intestinal toll-like receptor 4 knockout alters the functional capacity of the gut microbiome following irinotecan treatment|
KR Secombe, EE Crame, JSY Tam, HR Wardill, RJ Gibson, JK Coller, ...
Cancer Chemotherapy and Pharmacology 89 (2), 275-281, 2022
|Using patient-reported outcome measures to determine the role of the microbiome in cancer treatment-induced diarrhoea|
K Secombe, I Ball, C Subramaniam, G Al-Qadami, J Bowen, HR Wardill
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY 17, 174-175, 2021
|200| Intestinal epithelial TLR4 are crucial to chemotherapy toxicity development|
E Crame, HR Wardill, K Secombe, J Coller, J Bowen