Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice F Langevin, GP Crossan, IV Rosado, MJ Arends, KJ Patel Nature 475 (7354), 53-58, 2011 | 537 | 2011 |
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function JI Garaycoechea, GP Crossan, F Langevin, M Daly, MJ Arends, KJ Patel Nature 489 (7417), 571-575, 2012 | 404 | 2012 |
Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells JI Garaycoechea, GP Crossan, F Langevin, L Mulderrig, S Louzada, ... Nature 553 (7687), 171, 2018 | 361 | 2018 |
Endogenous formaldehyde is a hematopoietic stem cell genotoxin and metabolic carcinogen LB Pontel, IV Rosado, G Burgos-Barragan, JI Garaycoechea, R Yu, ... Molecular cell 60 (1), 177-188, 2015 | 335 | 2015 |
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia GP Crossan, L van der Weyden, IV Rosado, F Langevin, PHL Gaillard, ... Nature genetics 43 (2), 147-152, 2011 | 240 | 2011 |
Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway IV Rosado, F Langevin, GP Crossan, M Takata, KJ Patel Nature structural & molecular biology 18 (12), 1432-1434, 2011 | 206 | 2011 |
Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair MRG Hodskinson, J Silhan, GP Crossan, JI Garaycoechea, S Mukherjee, ... Molecular cell 54 (3), 472-484, 2014 | 161 | 2014 |
The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA GP Crossan, KJ Patel The Journal of pathology 226 (2), 326-337, 2012 | 142 | 2012 |
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response L Mulderrig, JI Garaycoechea, ZK Tuong, CL Millington, FA Dingler, ... Nature 600 (7887), 158-163, 2021 | 75 | 2021 |
Maternal aldehyde elimination during pregnancy preserves the fetal genome N Oberbeck, F Langevin, G King, N de Wind, GP Crossan, KJ Patel Molecular cell 55 (6), 807-817, 2014 | 66 | 2014 |
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity C Umansky, AE Morellato, M Rieckher, MA Scheidegger, MR Martinefski, ... Nature Communications 13 (1), 745, 2022 | 47 | 2022 |
Analysis of the novel fanconi anemia gene SLX4/FANCP in familial breast cancer cases JL Bakker, SE van Mil, G Crossan, N Sabbaghian, K De Leeneer, ... Human mutation 34 (1), 70-73, 2013 | 36 | 2013 |
DNA cross-link repair safeguards genomic stability during premeiotic germ cell development RJ Hill, GP Crossan Nature genetics 51 (8), 1283-1294, 2019 | 31 | 2019 |
Do mutational dynamics in stem cells explain the origin of common cancers? GP Crossan, JI Garaycoechea, KJ Patel Cell stem cell 16 (2), 111-112, 2015 | 9 | 2015 |
GCNA is a histone binding protein required for spermatogonial stem cell maintenance J Ribeiro, GP Crossan bioRxiv, 2022.02. 21.481287, 2022 | 4 | 2022 |
“Ring-fencing” BRCA1 tumor suppressor activity KJ Patel, GP Crossan, MRG Hodskinson Cancer cell 20 (6), 693-695, 2011 | 4 | 2011 |
Metformin: treating the cause of Fanconi anemia? GP Crossan Blood 128 (24), 2748-2750, 2016 | 3 | 2016 |
Aldehydes and Fanconi anaemia: the enemy within FP Langevin, JI Garaycoechea, GP Crossan, KJ Patel Medecine sciences: M/S 29 (4), 361-364, 2013 | 2 | 2013 |
The Fanconi Pathway Counteracts the Toxic Effects of Naturally Produced Aldehydes G Crossan, FP Langevin, MJ Arends, KJ Patel The Journal of Pathology 226 (1), S5, 2012 | 1 | 2012 |
Aldéhydes et anémie de Fanconi-L’ennemi de l’intérieur FPM Langevin, JI Garaycoechea, GP Crossan, KJ Patel médecine/sciences 29 (4), 361-364, 2013 | | 2013 |