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Dena Lyras
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Toxin B is essential for virulence of Clostridium difficile
D Lyras, JR O’Connor, PM Howarth, SP Sambol, GP Carter, ...
Nature 458 (7242), 1176-1179, 2009
8382009
Clostridium difficile infection
WK Smits, D Lyras, DB Lacy, MH Wilcox, EJ Kuijper
Nature reviews Disease primers 2 (1), 1-20, 2016
5472016
Epidemics of Diarrhea Caused by a Clindamycin-Resistant Strain of Clostridium difficile in Four Hospitals
S Johnson, MH Samore, KA Farrow, GE Killgore, FC Tenover, D Lyras, ...
New England Journal of Medicine 341 (22), 1645-1651, 1999
4471999
Binary Toxin Production in Clostridium difficile Is Regulated by CdtR, a LytTR Family Response Regulator
GP Carter, D Lyras, DL Allen, KE Mackin, PM Howarth, JR O'connor, ...
Journal of bacteriology 189 (20), 7290-7301, 2007
2812007
Expansion of the Clostridium perfringens toxin-based typing scheme
JI Rood, V Adams, J Lacey, D Lyras, BA McClane, SB Melville, RJ Moore, ...
Anaerobe 53, 5-10, 2018
2752018
Translocation and dissemination of commensal bacteria in post-stroke infection
D Stanley, LJ Mason, KE Mackin, YN Srikhanta, D Lyras, MD Prakash, ...
Nature medicine 22 (11), 1277-1284, 2016
2462016
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
SL Masters, V Lagou, I JÚru, PJ Baker, L Van Eyck, DA Parry, D Lawless, ...
Science translational medicine 8 (332), 332ra45-332ra45, 2016
2462016
Defining the roles of TcdA and TcdB in localized gastrointestinal disease, systemic organ damage, and the host response during Clostridium difficile infections
GP Carter, A Chakravorty, TA Pham Nguyen, S Mileto, F Schreiber, L Li, ...
MBio 6 (3), e00551-15, 2015
2042015
Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens
SM Tennant, EL Hartland, T Phumoonna, D Lyras, JI Rood, ...
Infection and immunity 76 (2), 639-645, 2008
1932008
The role of toxin A and toxin B in the virulence of Clostridium difficile
GP Carter, JI Rood, D Lyras
Trends in microbiology 20 (1), 21-29, 2012
1762012
Construction and analysis of chromosomal Clostridium difficile mutants
JR O'Connor, D Lyras, KA Farrow, V Adams, DR Powell, J Hinds, ...
Molecular microbiology 61 (5), 1335-1351, 2006
1752006
The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile
GP Carter, GR Douce, R Govind, PM Howarth, KE Mackin, J Spencer, ...
PLoS pathogens 7 (10), e1002317, 2011
1622011
Environmental Response and Autoregulation of Clostridium difficile TxeR, a Sigma Factor for Toxin Gene Expression
N Mani, D Lyras, L Barroso, P Howarth, T Wilkins, JI Rood, ...
Journal of bacteriology 184 (21), 5971-5978, 2002
1532002
The α‐toxin of Clostridium septicum is essential for virulence
CL Kennedy, EO Krejany, LF Young, JR O'Connor, MM Awad, RL Boyd, ...
Molecular microbiology 57 (5), 1357-1366, 2005
1492005
Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen
MM Awad, PA Johanesen, GP Carter, E Rose, D Lyras
Gut microbes 5 (5), 579-593, 2014
1412014
The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia
CA Cowardin, EL Buonomo, MM Saleh, MG Wilson, SL Burgess, ...
Nature microbiology 1 (8), 1-10, 2016
1372016
Emergence of a Ribotype 244 Strain of Clostridium difficile Associated With Severe Disease and Related to the Epidemic Ribotype 027 Strain
SK Lim, RL Stuart, KE Mackin, GP Carter, D Kotsanas, MJ Francis, ...
Clinical infectious diseases 58 (12), 1723-1730, 2014
1282014
The role of toxin A and toxin B in Clostridium difficile-associated disease: past and present perspectives
GP Carter, JI Rood, D Lyras
Gut microbes 1 (1), 58-64, 2010
1262010
Programmed Cellular Necrosis Mediated by the Pore-Forming α-Toxin from Clostridium septicum
CL Kennedy, DJ Smith, D Lyras, A Chakravorty, JI Rood
PLoS pathogens 5 (7), e1000516, 2009
1222009
Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β
ML Kim, JJ Chae, YH Park, D De Nardo, RA Stirzaker, HJ Ko, H Tye, ...
Journal of Experimental Medicine 212 (6), 927-938, 2015
1192015
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