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Kate Smith
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Structural biology and regulation of protein import into the nucleus
M Christie, CW Chang, G Róna, KM Smith, AG Stewart, AAS Takeda, ...
Journal of molecular biology 428 (10), 2060-2090, 2016
2772016
The C-terminal 18 amino acid region of dengue virus NS5 regulates its subcellular localization and contains a conserved arginine residue essential for infectious virus production
MYF Tay, K Smith, IHW Ng, KWK Chan, Y Zhao, EE Ooi, J Lescar, D Luo, ...
PLoS pathogens 12 (9), e1005886, 2016
862016
Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses
KM Smith, S Tsimbalyuk, MR Edwards, EM Cross, J Batra, ...
Nature communications 9 (1), 3703, 2018
612018
Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection
C Wang, SNY Yang, K Smith, JK Forwood, DA Jans
Biochemical and biophysical research communications 493 (4), 1555-1559, 2017
542017
Targeting nuclear LSD1 to reprogram cancer cells and reinvigorate exhausted T cells via a novel LSD1-EOMES switch
WJ Tu, RD McCuaig, AHY Tan, K Hardy, N Seddiki, S Ali, JE Dahlstrom, ...
Frontiers in Immunology 11, 1228, 2020
522020
Zika Virus NS5 forms supramolecular nuclear bodies that sequester importin-α and modulate the host immune and pro-inflammatory response in neuronal cells
IHW Ng, KWK Chan, MJA Tan, CP Gwee, KM Smith, SJ Jeffress, WG Saw, ...
ACS infectious diseases 5 (6), 932-948, 2019
462019
Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting
KM Smith, V Di Antonio, L Bellucci, DR Thomas, F Caporuscio, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1865 (8), 1114-1129, 2018
352018
Structural basis for importin-α binding of the human immunodeficiency virus tat
KM Smith, Z Himiari, S Tsimbalyuk, JK Forwood
Scientific reports 7 (1), 1650, 2017
322017
Lysozyme conformational changes with ionic liquids: Spectroscopic, small angle x-ray scattering and crystallographic study
Q Han, KM Smith, C Darmanin, TM Ryan, CJ Drummond, TL Greaves
Journal of Colloid and Interface Science 585, 433-443, 2021
302021
Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE) 4 inhibitor V11294A in healthy volunteers
DD Gale, LJ Landells, D Spina, AJ Miller, K Smith, T Nichols, Y Rotshteyn, ...
British journal of clinical pharmacology 54 (5), 478-484, 2002
282002
MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity
TS Munasinghe, MR Edwards, S Tsimbalyuk, OA Vogel, KM Smith, ...
Nature Communications 13 (1), 1604, 2022
232022
Fast fragment-and compound-screening pipeline at the Swiss Light Source
JW Kaminski, L Vera, DP Stegmann, J Vering, D Eris, KML Smith, ...
Biological Crystallography 78 (3), 328-336, 2022
202022
Pharmacodynamic-pharmacokinetic (PD/PK) profile of the phosphodiesterase (PDE) 4 inhibitor, V11294A, in human volunteers
DD Gale, LJ Landells, D Spina, AJ Miller, K Smith, T Nichols, Y Rotshteyn, ...
Am. J. Respir. Crit Care Med 159, A611, 1999
191999
Oral administration of the phosphodiesterase (PDE) 4 inhibitor, V11294A inhibits ex-vivo agonist-induced cell activation
LJ Landells, MW Jensen, D Spina, D Donigi Gale, AJ Miller, T Nichols, ...
Eur Respir J 12 (suppl 12), 362s, 1998
171998
The Enhanced In Vivo Activity of the Combination of a MEK and a PI3K Inhibitor Correlates with [18F]-FLT PET in Human Colorectal Cancer Xenograft Tumour …
EJ Haagensen, HD Thomas, I Wilson, SJ Harnor, SL Payne, T Rennison, ...
PLoS One 8 (12), e81763, 2013
162013
Repeat spillover of beak and feather disease virus into an endangered parrot highlights the risk associated with endemic pathogen loss in endangered species
S Das, K Smith, S Sarker, A Peters, K Adriaanse, P Eden, SA Ghorashi, ...
Journal of wildlife diseases 56 (4), 896-906, 2020
152020
Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids
Q Han, Y Su, KM Smith, J Binns, CJ Drummond, C Darmanin, TL Greaves
Journal of Colloid and Interface Science 650, 1393-1405, 2023
142023
Probing ligand binding of endothiapepsin bytemperature-resolved'macromolecular crystallography
CY Huang, S Aumonier, S Engilberge, D Eris, KML Smith, F Leonarski, ...
Acta Crystallographica Section D: Structural Biology 78 (8), 964-974, 2022
112022
Assessing circovirus gene flow in multiple spill-over events
S Das, K Smith, S Sarker, A Peters, K Adriaanse, P Eden, SA Ghorashi, ...
Virus genes 55 (6), 802-814, 2019
112019
Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase
YB Khandokar, P Srivastava, N Cowieson, S Sarker, D Aragao, S Das, ...
Journal of Biological Chemistry 292 (50), 20461-20471, 2017
102017
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