|A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor|
BJ Gu, W Zhang, RA Worthington, R Sluyter, P Dao-Ung, S Petrou, ...
Journal of Biological Chemistry 276 (14), 11135-11142, 2001
|Expression of P2X7 purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X7 receptors|
BJ Gu, WY Zhang, LJ Bendall, IP Chessell, GN Buell, JS Wiley
American Journal of Physiology-Cell Physiology 279 (4), C1189-C1197, 2000
|Adenosine triphosphate–induced shedding of CD23 and L-selectin (CD62L) from lymphocytes is mediated by the same receptor but different metalloproteases|
B Gu, LJ Bendall, JS Wiley
Blood 92 (3), 946-951, 1998
|P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region|
ML Smart, B Gu, RG Panchal, J Wiley, B Cromer, DA Williams, S Petrou
Journal of Biological Chemistry 278 (10), 8853-8860, 2003
|An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor|
JS Wiley, LP Dao-Ung, C Li, AN Shemon, BJ Gu, ML Smart, SJ Fuller, ...
Journal of Biological Chemistry 278 (19), 17108-17113, 2003
|A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study|
JS Wiley, LP Dao-Ung, BJ Gu, R Sluyter, AN Shemon, C Li, J Taper, ...
The Lancet 359 (9312), 1114-1119, 2002
|A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages|
AN Shemon, R Sluyter, SL Fernando, AL Clarke, LP Dao-Ung, KK Skarratt, ...
Journal of Biological Chemistry 281 (4), 2079-2086, 2006
|The human P2X7 receptor and its role in innate immunity|
JS Wiley, R Sluyter, BJ Gu, L Stokes, SJ Fuller
Tissue antigens 78 (5), 321-332, 2011
|A systemic view of Alzheimer disease—insights from amyloid-β metabolism beyond the brain|
J Wang, BJ Gu, CL Masters, YJ Wang
Nature Reviews Neurology 13 (10), 612, 2017
|An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor|
BJ Gu, R Sluyter, KK Skarratt, AN Shemon, LP Dao-Ung, SJ Fuller, ...
Journal of Biological Chemistry 279 (30), 31287-31295, 2004
|Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion|
L Stokes, SJ Fuller, R Sluyter, KK Skarratt, BJ Gu, JS Wiley
The FASEB Journal 24 (8), 2916-2927, 2010
|Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor|
BJ Gu, JS Wiley
Blood 107 (12), 4946-4953, 2006
|Genetics of the P2X7 receptor and human disease|
SJ Fuller, L Stokes, KK Skarratt, BJ Gu, JS Wiley
Purinergic signalling 5 (2), 257-262, 2009
|The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP|
BJ Gu, BM Saunders, C Jursik, JS Wiley
Blood 115 (8), 1621-1631, 2010
|Extracellular ATP dissociates nonmuscle myosin from P2X7 complex: this dissociation regulates P2X7 pore formation|
BJ Gu, C Rathsam, L Stokes, AB McGeachie, JS Wiley
American Journal of Physiology-Cell Physiology 297 (2), C430-C439, 2009
|P2X7 is a scavenger receptor for apoptotic cells in the absence of its ligand, extracellular ATP|
BJ Gu, BM Saunders, S Petrou, JS Wiley
The Journal of Immunology 187 (5), 2365-2375, 2011
|Point mutations confer loss of ATP‐induced human P2X7 receptor function|
RA Worthington, ML Smart, BJ Gu, DA Williams, S Petrou, JS Wiley, ...
FEBS letters 512 (1-3), 43-46, 2002
|Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis|
W Li, Y Tai, J Zhou, W Gu, Z Bai, T Zhou, Z Zhong, PA McCue, N Sang, ...
Cell cycle 11 (12), 2348-2358, 2012
|A 5′ intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1–2% of the Caucasian population|
KK Skarratt, SJ Fuller, R Sluyter, LP Dao-Ung, BJ Gu, JS Wiley
FEBS letters 579 (12), 2675-2678, 2005
|Gankyrin activates IL-8 to promote hepatic metastasis of colorectal cancer|
Z Bai, Y Tai, W Li, C Zhen, W Gu, Z Jian, Q Wang, JE Lin, Q Zhao, W Gong, ...
Cancer research 73 (14), 4548-4558, 2013