Matthew David Perry
Matthew David Perry
Senior Lecturer, Department of Pharmacology, School of Medical Sciences, UNSW
Verified email at
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hERG K+ channels: structure, function, and clinical significance
JI Vandenberg, MD Perry, MJ Perrin, SA Mann, Y Ke, AP Hill
Physiological reviews, 2012
Structural determinants of HERG channel block by clofilium and ibutilide
M Perry, MJ de Groot, R Helliwell, D Leishman, M Tristani-Firouzi, ...
Molecular pharmacology 66 (2), 240-249, 2004
Symposium review: revealing the structural basis of action of hERG potassium channel activators and blockers
M Perry, M Sanguinetti, J Mitcheson
The Journal of physiology 588 (17), 3157-3167, 2010
The low-potency, voltage-dependent HERG blocker propafenone—molecular determinants and drug trapping
HJ Witchel, CE Dempsey, RB Sessions, M Perry, JT Milnes, JC Hancox, ...
Molecular pharmacology 66 (5), 1201-1212, 2004
A universal and robust integrated platform for the scalable production of human cardiomyocytes from pluripotent stem cells
H Fonoudi, H Ansari, S Abbasalizadeh, MR Larijani, S Kiani, ...
Stem cells translational medicine 4 (12), 1482-1494, 2015
The N–terminal tail of hERG contains an amphipathic α–helix that regulates channel deactivation
CA Ng, MJ Hunter, MD Perry, M Mobli, Y Ke, PW Kuchel, GF King, D Stock, ...
PloS one 6 (1), e16191, 2011
Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs
M Perry, PJ Stansfeld, J Leaney, C Wood, MJ De Groot, D Leishman, ...
Molecular pharmacology 69 (2), 509-519, 2006
Molecular determinants of high-affinity drug binding to HERG channels.
JS Mitcheson, MD Perry
Current opinion in drug discovery & development 6 (5), 667-674, 2003
Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator
M Perry, FB Sachse, MC Sanguinetti
Proceedings of the National Academy of Sciences 104 (34), 13827-13832, 2007
PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance
M Perry, FB Sachse, J Abbruzzese, MC Sanguinetti
Proceedings of the National Academy of Sciences 106 (47), 20075-20080, 2009
The S4–S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating
CA Ng, MD Perry, PS Tan, AP Hill, PW Kuchel, JI Vandenberg
PloS one 7 (2), e31640, 2012
Altered cryptal expression of luminal potassium (BK) channels in ulcerative colitis
GI Sandle, MD Perry, T Mathialahan, JE Linley, P Robinson, M Hunter, ...
The Journal of Pathology: A Journal of the Pathological Society of Great …, 2007
High-throughput phenotyping of heteromeric human ether-a-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants
CA Ng, MD Perry, W Liang, NJ Smith, B Foo, A Shrier, GL Lukacs, AP Hill, ...
Heart rhythm 17 (3), 492-500, 2020
Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11. 1 channels
CA Ng, K Phan, AP Hill, JI Vandenberg, MD Perry
Journal of Biological Chemistry 289 (37), 25822-25832, 2014
Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels
PS Tan, MD Perry, CA Ng, JI Vandenberg, AP Hill
Journal of General Physiology 140 (3), 293-306, 2012
Structural determinants for high‐affinity block of hERG potassium channels
J Mitcheson, M Perry, P Stansfeld, MC Sanguinetti, H Witchel, J Hancox
The hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome …, 2005
Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2
A Sadrieh, L Domanski, J Pitt-Francis, SA Mann, EC Hodkinson, CA Ng, ...
Nature communications 5 (1), 5069, 2014
Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes
SA Mann, M Imtiaz, A Winbo, A Rydberg, MD Perry, JP Couderc, ...
Journal of molecular and cellular cardiology 100, 25-34, 2016
Principal role of adenylyl cyclase 6 in K+ channel regulation and vasodilator signalling in vascular smooth muscle cells
CP Nelson, RD Rainbow, JL Brignell, MD Perry, JM Willets, NW Davies, ...
Cardiovascular research 91 (4), 694-702, 2011
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study
STARSurg Collaborative, ...
BJS open 2 (6), 400-410, 2018
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