| Initial sequencing and analysis of the human genome ES Lander, LM Linton, B Birren, C Nusbaum, MC Zody, J Baldwin, ... Macmillan Publishers Ltd., 2001 | 25585* | 2001 |
| The COG database: an updated version includes eukaryotes RL Tatusov, ND Fedorova, JD Jackson, AR Jacobs, B Kiryutin, EV Koonin, ... BMC bioinformatics 4 (1), 1-14, 2003 | 4126 | 2003 |
| A genomic perspective on protein families RL Tatusov, EV Koonin, DJ Lipman Science 278 (5338), 631-637, 1997 | 3831 | 1997 |
| The COG database: a tool for genome-scale analysis of protein functions and evolution RL Tatusov, MY Galperin, DA Natale, EV Koonin Nucleic acids research 28 (1), 33-36, 2000 | 3123 | 2000 |
| Small CRISPR RNAs guide antiviral defense in prokaryotes SJJ Brouns, MM Jore, M Lundgren, ER Westra, RJH Slijkhuis, ... Science 321 (5891), 960-964, 2008 | 2205 | 2008 |
| Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system B Zetsche, JS Gootenberg, OO Abudayyeh, IM Slaymaker, KS Makarova, ... Cell 163 (3), 759-771, 2015 | 2175 | 2015 |
| Evolution and classification of the CRISPR–Cas systems KS Makarova, DH Haft, R Barrangou, SJJ Brouns, E Charpentier, ... Nature Reviews Microbiology 9 (6), 467-477, 2011 | 2115 | 2011 |
| AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes AF Neuwald, L Aravind, JL Spouge, EV Koonin Genome research 9 (1), 27-43, 1999 | 2009 | 1999 |
| The COG database: new developments in phylogenetic classification of proteins from complete genomes RL Tatusov, DA Natale, IV Garkavtsev, TA Tatusova, UT Shankavaram, ... Nucleic acids research 29 (1), 22-28, 2001 | 1976 | 2001 |
| Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent J Linnen, J Wages, ZY Zhang-Keck, KE Fry, KZ Krawczynski, H Alter, ... Science 271 (5248), 505-508, 1996 | 1954 | 1996 |
| De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling IE Wertz, KM O'rourke, H Zhou, M Eby, L Aravind, S Seshagiri, P Wu, ... Nature 430 (7000), 694-699, 2004 | 1777 | 2004 |
| Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis RS Stephens, S Kalman, C Lammel, J Fan, R Marathe, L Aravind, ... Science 282 (5389), 754-759, 1998 | 1768 | 1998 |
| In vivo genome editing using Staphylococcus aureus Cas9 FA Ran, L Cong, WX Yan, DA Scott, JS Gootenberg, AJ Kriz, B Zetsche, ... Nature 520 (7546), 186-191, 2015 | 1720 | 2015 |
| Bacterial rhodopsin: evidence for a new type of phototrophy in the sea O Béja, L Aravind, EV Koonin, MT Suzuki, A Hadd, LP Nguyen, ... Science 289 (5486), 1902-1906, 2000 | 1503 | 2000 |
| An updated evolutionary classification of CRISPR–Cas systems KS Makarova, YI Wolf, OS Alkhnbashi, F Costa, SA Shah, SJ Saunders, ... Nature Reviews Microbiology 13 (11), 722-736, 2015 | 1487 | 2015 |
| Molecular evolution: a phylogenetic approach RDM Page, EC Holmes John Wiley & Sons, 2009 | 1448 | 2009 |
| Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements AA Schäffer, L Aravind, TL Madden, S Shavirin, JL Spouge, YI Wolf, ... Nucleic acids research 29 (14), 2994-3005, 2001 | 1428 | 2001 |
| Comparative genomics of the lactic acid bacteria K Makarova, A Slesarev, Y Wolf, A Sorokin, B Mirkin, E Koonin, A Pavlov, ... Proceedings of the National Academy of Sciences 103 (42), 15611-15616, 2006 | 1387 | 2006 |
| Helicases: amino acid sequence comparisons and structure-function relationships AE Gorbalenya, EV Koonin Current opinion in structural biology 3 (3), 419-429, 1993 | 1273 | 1993 |
| A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and … KS Makarova, NV Grishin, SA Shabalina, YI Wolf, EV Koonin Biology direct 1 (1), 7, 2006 | 1231 | 2006 |
Aravind LSenior Investigator, National Institutes of HealthVerified email at mail.nih.gov
