John B. Bruning
John B. Bruning
Associate Professor, University of Adelaide
Verified email at - Homepage
Cited by
Cited by
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
JH Choi, AS Banks, TM Kamenecka, SA Busby, MJ Chalmers, N Kumar, ...
Nature 477 (7365), 477-481, 2011
Partial agonists activate PPARγ using a helix 12 independent mechanism
JB Bruning, MJ Chalmers, S Prasad, SA Busby, TM Kamenecka, Y He, ...
Structure 15 (10), 1258-1271, 2007
Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-δ p66 subunit and flap endonuclease-1
JB Bruning, Y Shamoo
Structure 12 (12), 2209-2219, 2004
DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex
J Zhang, MJ Chalmers, KR Stayrook, LL Burris, Y Wang, SA Busby, ...
Nature structural & molecular biology 18 (5), 556-563, 2011
Review of the structural and dynamic mechanisms of PPARγ partial agonism
AJ Kroker, JB Bruning
PPAR research 2015, 2015
Rare variants in single-minded 1 (SIM1) are associated with severe obesity
S Ramachandrappa, A Raimondo, AMG Cali, JM Keogh, E Henning, ...
The Journal of clinical investigation 123 (7), 3042-3050, 2013
NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses
KW Nettles, JB Bruning, G Gil, J Nowak, SK Sharma, JB Hahm, K Kulp, ...
Nature chemical biology 4 (4), 241-247, 2008
Structure of the Mycobacterium tuberculosis d-Alanine:d-Alanine Ligase, a Target of the Antituberculosis Drug d-Cycloserine
JB Bruning, AC Murillo, O Chacon, RG Barletta, JC Sacchettini
Antimicrobial agents and chemotherapy 55 (1), 291-301, 2011
Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features
A Bonnefond, A Raimondo, F Stutzmann, M Ghoussaini, ...
The Journal of clinical investigation 123 (7), 3037-3041, 2013
Structural plasticity in the oestrogen receptor ligand‐binding domain
KW Nettles, JB Bruning, G Gil, EE O'Neill, J Nowak, A Hughs, Y Kim, ...
EMBO reports 8 (6), 563-568, 2007
Coupling of receptor conformation and ligand orientation determine graded activity
JB Bruning, AA Parent, G Gil, M Zhao, J Nowak, MC Pace, CL Smith, ...
Nature chemical biology 6 (11), 837-843, 2010
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
DJ Kojetin, E Matta-Camacho, TS Hughes, S Srinivasan, JC Nwachukwu, ...
Nature communications 6 (1), 8013, 2015
Pharmacological repression of PPARγ promotes osteogenesis
DP Marciano, DS Kuruvilla, SV Boregowda, A Asteian, TS Hughes, ...
Nature communications 6 (1), 7443, 2015
Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity
Y Jia, G Shen, S Nguyen, Y Zhang, KS Huang, HY Ho, WS Hor, CH Yang, ...
BioRxiv, 2020.04. 09.034942, 2020
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method
SY Dai, MJ Chalmers, J Bruning, KS Bramlett, HE Osborne, ...
Proceedings of the National Academy of Sciences 105 (20), 7171-7176, 2008
PPARG post-translational modifications regulate bone formation and bone resorption
LA Stechschulte, PJ Czernik, ZC Rotter, FN Tausif, CA Corzo, ...
EBioMedicine 10, 174-184, 2016
Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands
HB Zhou, KW Nettles, JB Bruning, Y Kim, A Joachimiak, S Sharma, ...
Chemistry & biology 14 (6), 659-669, 2007
The TB Structural Genomics Consortium: a decade of progress
N Chim, JE Habel, JM Johnston, I Krieger, L Miallau, ...
Tuberculosis 91 (2), 155-172, 2011
Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein
MCM Reddy, SK Palaninathan, JB Bruning, C Thurman, D Smith, ...
Journal of biological chemistry 284 (52), 36581-36591, 2009
Expressing a moth abcc2 gene in transgenic Drosophila causes susceptibility to Bt Cry1Ac without requiring a cadherin-like protein receptor
T Stevens, S Song, JB Bruning, A Choo, SW Baxter
Insect biochemistry and molecular biology 80, 61-70, 2017
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