| Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation JH Choi, AS Banks, TM Kamenecka, SA Busby, MJ Chalmers, N Kumar, ... Nature 477 (7365), 477-481, 2011 | 600 | 2011 |
| Partial agonists activate PPARγ using a helix 12 independent mechanism JB Bruning, MJ Chalmers, S Prasad, SA Busby, TM Kamenecka, Y He, ... Structure 15 (10), 1258-1271, 2007 | 410 | 2007 |
| Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-δ p66 subunit and flap endonuclease-1 JB Bruning, Y Shamoo Structure 12 (12), 2209-2219, 2004 | 246 | 2004 |
| DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex J Zhang, MJ Chalmers, KR Stayrook, LL Burris, Y Wang, SA Busby, ... Nature structural & molecular biology 18 (5), 556-563, 2011 | 230 | 2011 |
| Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism AJ Kroker, JB Bruning PPAR research 2015 (1), 816856, 2015 | 203 | 2015 |
| Rare variants in single-minded 1 (SIM1) are associated with severe obesity S Ramachandrappa, A Raimondo, AMG Cali, JM Keogh, E Henning, ... The Journal of clinical investigation 123 (7), 3042-3050, 2013 | 189 | 2013 |
| NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses KW Nettles, JB Bruning, G Gil, J Nowak, SK Sharma, JB Hahm, K Kulp, ... Nature chemical biology 4 (4), 241-247, 2008 | 179 | 2008 |
| Structure of the Mycobacterium tuberculosis d-Alanine:d-Alanine Ligase, a Target of the Antituberculosis Drug d-Cycloserine JB Bruning, AC Murillo, O Chacon, RG Barletta, JC Sacchettini Antimicrobial agents and chemotherapy 55 (1), 291-301, 2011 | 166 | 2011 |
| Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features A Bonnefond, A Raimondo, F Stutzmann, M Ghoussaini, ... The Journal of clinical investigation 123 (7), 3037-3041, 2013 | 162 | 2013 |
| Structural plasticity in the oestrogen receptor ligand‐binding domain KW Nettles, JB Bruning, G Gil, EE O'Neill, J Nowak, A Hughs, Y Kim, ... EMBO reports 8 (6), 563-568, 2007 | 150 | 2007 |
| Coupling of receptor conformation and ligand orientation determine graded activity JB Bruning, AA Parent, G Gil, M Zhao, J Nowak, MC Pace, CL Smith, ... Nature chemical biology 6 (11), 837-843, 2010 | 144 | 2010 |
| Structural mechanism for signal transduction in RXR nuclear receptor heterodimers DJ Kojetin, E Matta-Camacho, TS Hughes, S Srinivasan, JC Nwachukwu, ... Nature communications 6 (1), 8013, 2015 | 136 | 2015 |
| Pharmacological repression of PPARγ promotes osteogenesis DP Marciano, DS Kuruvilla, SV Boregowda, A Asteian, TS Hughes, ... Nature communications 6 (1), 7443, 2015 | 120 | 2015 |
| Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity Y Jia, G Shen, S Nguyen, Y Zhang, KS Huang, HY Ho, WS Hor, CH Yang, ... BioRxiv, 2020.04. 09.034942, 2020 | 117 | 2020 |
| Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method SY Dai, MJ Chalmers, J Bruning, KS Bramlett, HE Osborne, ... Proceedings of the National Academy of Sciences 105 (20), 7171-7176, 2008 | 106 | 2008 |
| PPARG post-translational modifications regulate bone formation and bone resorption LA Stechschulte, PJ Czernik, ZC Rotter, FN Tausif, CA Corzo, ... EBioMedicine 10, 174-184, 2016 | 87 | 2016 |
| Elemental isomerism: A boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands HB Zhou, KW Nettles, JB Bruning, Y Kim, A Joachimiak, S Sharma, ... Chemistry & biology 14 (6), 659-669, 2007 | 77 | 2007 |
| The TB Structural Genomics Consortium: a decade of progress N Chim, JE Habel, JM Johnston, I Krieger, L Miallau, ... Tuberculosis 91 (2), 155-172, 2011 | 62 | 2011 |
| Expressing a moth abcc2 gene in transgenic Drosophila causes susceptibility to Bt Cry1Ac without requiring a cadherin-like protein receptor T Stevens, S Song, JB Bruning, A Choo, SW Baxter Insect Biochemistry and Molecular Biology 80, 61-70, 2017 | 53 | 2017 |
| Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein MCM Reddy, SK Palaninathan, JB Bruning, C Thurman, D Smith, ... Journal of Biological Chemistry 284 (52), 36581-36591, 2009 | 52 | 2009 |
