John B. Bruning
John B. Bruning
Senior Lecturer (tenured), University of Adelaide
Verified email at adelaide.edu.au - Homepage
TitleCited byYear
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
JH Choi, AS Banks, TM Kamenecka, SA Busby, MJ Chalmers, N Kumar, ...
Nature 477 (7365), 477, 2011
4252011
Partial agonists activate PPARγ using a helix 12 independent mechanism
JB Bruning, MJ Chalmers, S Prasad, SA Busby, TM Kamenecka, Y He, ...
Structure 15 (10), 1258-1271, 2007
2842007
Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-δ p66 subunit and flap endonuclease-1
JB Bruning, Y Shamoo
Structure 12 (12), 2209-2219, 2004
1772004
DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex
J Zhang, MJ Chalmers, KR Stayrook, LL Burris, Y Wang, SA Busby, ...
Nature structural & molecular biology 18 (5), 556, 2011
1672011
NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses
KW Nettles, JB Bruning, G Gil, J Nowak, SK Sharma, JB Hahm, K Kulp, ...
Nature chemical biology 4 (4), 241, 2008
1282008
Structural plasticity in the oestrogen receptor ligand‐binding domain
KW Nettles, JB Bruning, G Gil, EE O'Neill, J Nowak, A Hughs, Y Kim, ...
EMBO reports 8 (6), 563-568, 2007
1132007
Rare variants in single-minded 1 (SIM1) are associated with severe obesity
S Ramachandrappa, A Raimondo, AMG Cali, JM Keogh, E Henning, ...
The Journal of clinical investigation 123 (7), 3042-3050, 2013
1102013
Coupling of receptor conformation and ligand orientation determine graded activity
JB Bruning, AA Parent, G Gil, M Zhao, J Nowak, MC Pace, CL Smith, ...
Nature chemical biology 6 (11), 837, 2010
1042010
Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features
A Bonnefond, A Raimondo, F Stutzmann, M Ghoussaini, ...
The Journal of clinical investigation 123 (7), 3037-3041, 2013
902013
Structure of the Mycobacterium tuberculosis D-alanine: D-alanine ligase, a target of the antituberculosis drug D-cycloserine
JB Bruning, AC Murillo, O Chacon, RG Barletta, JC Sacchettini
Antimicrobial agents and chemotherapy 55 (1), 291-301, 2011
902011
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method
SY Dai, MJ Chalmers, J Bruning, KS Bramlett, HE Osborne, ...
Proceedings of the National Academy of Sciences 105 (20), 7171-7176, 2008
802008
Pharmacological repression of PPARγ promotes osteogenesis
DP Marciano, DS Kuruvilla, SV Boregowda, A Asteian, TS Hughes, ...
Nature communications 6, 7443, 2015
722015
Review of the structural and dynamic mechanisms of PPARγ partial agonism
AJ Kroker, JB Bruning
PPAR research 2015, 2015
642015
Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands
HB Zhou, KW Nettles, JB Bruning, Y Kim, A Joachimiak, S Sharma, ...
Chemistry & biology 14 (6), 659-669, 2007
612007
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
DJ Kojetin, E Matta-Camacho, TS Hughes, S Srinivasan, JC Nwachukwu, ...
Nature communications 6, 8013, 2015
582015
The TB Structural Genomics Consortium: a decade of progress
N Chim, JE Habel, JM Johnston, I Krieger, L Miallau, ...
Tuberculosis 91 (2), 155-172, 2011
452011
Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein
MCM Reddy, SK Palaninathan, JB Bruning, C Thurman, D Smith, ...
Journal of Biological Chemistry 284 (52), 36581-36591, 2009
362009
PPARG post-translational modifications regulate bone formation and bone resorption
LA Stechschulte, PJ Czernik, ZC Rotter, FN Tausif, CA Corzo, ...
EBioMedicine 10, 174-184, 2016
352016
Macrocyclic protease inhibitors with reduced peptide character.
AAD Chua KC, Pietsch M, Zhang X, Hautmann S, Chan HY, Bruning JB, GŁtschow M
Angew Chem Int Ed Engl. 53 (30), 7828-31, 2014
22*2014
Expressing a moth abcc2 gene in transgenic Drosophila causes susceptibility to Bt Cry1Ac without requiring a cadherin-like protein receptor
T Stevens, S Song, JB Bruning, A Choo, SW Baxter
Insect biochemistry and molecular biology 80, 61-70, 2017
202017
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Articles 1–20