John B. Bruning
John B. Bruning
Senior Lecturer (tenured), University of Adelaide
Verified email at - Homepage
Cited by
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Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
JH Choi, AS Banks, TM Kamenecka, SA Busby, MJ Chalmers, N Kumar, ...
Nature 477 (7365), 477-481, 2011
Partial agonists activate PPARγ using a helix 12 independent mechanism
JB Bruning, MJ Chalmers, S Prasad, SA Busby, TM Kamenecka, Y He, ...
Structure 15 (10), 1258-1271, 2007
Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-δ p66 subunit and flap endonuclease-1
JB Bruning, Y Shamoo
Structure 12 (12), 2209-2219, 2004
DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex
J Zhang, MJ Chalmers, KR Stayrook, LL Burris, Y Wang, SA Busby, ...
Nature structural & molecular biology 18 (5), 556, 2011
NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses
KW Nettles, JB Bruning, G Gil, J Nowak, SK Sharma, JB Hahm, K Kulp, ...
Nature chemical biology 4 (4), 241-247, 2008
Rare variants in single-minded 1 (SIM1) are associated with severe obesity
S Ramachandrappa, A Raimondo, AMG Cali, JM Keogh, E Henning, ...
The Journal of clinical investigation 123 (7), 3042-3050, 2013
Structural plasticity in the oestrogen receptor ligand‐binding domain
KW Nettles, JB Bruning, G Gil, EE O'Neill, J Nowak, A Hughs, Y Kim, ...
EMBO reports 8 (6), 563-568, 2007
Coupling of receptor conformation and ligand orientation determine graded activity
JB Bruning, AA Parent, G Gil, M Zhao, J Nowak, MC Pace, CL Smith, ...
Nature chemical biology 6 (11), 837, 2010
Structure of the Mycobacterium tuberculosis D-alanine: D-alanine ligase, a target of the antituberculosis drug D-cycloserine
JB Bruning, AC Murillo, O Chacon, RG Barletta, JC Sacchettini
Antimicrobial agents and chemotherapy 55 (1), 291-301, 2011
Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features
A Bonnefond, A Raimondo, F Stutzmann, M Ghoussaini, ...
The Journal of clinical investigation 123 (7), 3037-3041, 2013
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method
SY Dai, MJ Chalmers, J Bruning, KS Bramlett, HE Osborne, ...
Proceedings of the National Academy of Sciences 105 (20), 7171-7176, 2008
Pharmacological repression of PPARγ promotes osteogenesis
DP Marciano, DS Kuruvilla, SV Boregowda, A Asteian, TS Hughes, ...
Nature communications 6 (1), 1-7, 2015
Review of the structural and dynamic mechanisms of PPARγ partial agonism
AJ Kroker, JB Bruning
PPAR research 2015, 2015
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
DJ Kojetin, E Matta-Camacho, TS Hughes, S Srinivasan, JC Nwachukwu, ...
Nature communications 6 (1), 1-14, 2015
Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands
HB Zhou, KW Nettles, JB Bruning, Y Kim, A Joachimiak, S Sharma, ...
Chemistry & biology 14 (6), 659-669, 2007
The TB structural genomics consortium: a decade of progress
N Chim, JE Habel, JM Johnston, I Krieger, L Miallau, ...
Tuberculosis 91 (2), 155-172, 2011
PPARG post-translational modifications regulate bone formation and bone resorption
LA Stechschulte, PJ Czernik, ZC Rotter, FN Tausif, CA Corzo, ...
EBioMedicine 10, 174-184, 2016
Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein
MCM Reddy, SK Palaninathan, JB Bruning, C Thurman, D Smith, ...
Journal of Biological Chemistry 284 (52), 36581-36591, 2009
Expressing a moth abcc2 gene in transgenic Drosophila causes susceptibility to Bt Cry1Ac without requiring a cadherin-like protein receptor
T Stevens, S Song, JB Bruning, A Choo, SW Baxter
Insect biochemistry and molecular biology 80, 61-70, 2017
Macrocyclic protease inhibitors with reduced peptide character.
AAD Chua KC, Pietsch M, Zhang X, Hautmann S, Chan HY, Bruning JB, GŁtschow M
Angew Chem Int Ed Engl. 53 (30), 7828-31, 2014
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