Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1 F Shabanpoor, M Akhter Hossain, PJ Ryan, A Belgi, S Layfield, M Kocan, ... Journal of medicinal chemistry 55 (4), 1671-1681, 2012 | 92 | 2012 |
Use of a temporary “solubilizing” peptide tag for the Fmoc solid-phase synthesis of human insulin glargine via use of regioselective disulfide bond formation MA Hossain, A Belgi, F Lin, S Zhang, F Shabanpoor, L Chan, C Belyea, ... Bioconjugate chemistry 20 (7), 1390-1396, 2009 | 90 | 2009 |
Dicarba α-Conotoxin Vc1.1 Analogues with Differential Selectivity for Nicotinic Acetylcholine and GABAB Receptors BJ Van Lierop, SD Robinson, SN Kompella, A Belgi, JR McArthur, A Hung, ... ACS chemical biology 8 (8), 1815-1821, 2013 | 79 | 2013 |
Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets S Chhabra, A Belgi, P Bartels, BJ van Lierop, SD Robinson, SN Kompella, ... Journal of Medicinal Chemistry 57 (23), 9933-9944, 2014 | 66 | 2014 |
Structure and function relationship of murine insulin-like peptide 5 (INSL5): free C-terminus is essential for RXFP4 receptor binding and activation A Belgi, MA Hossain, F Shabanpoor, L Chan, S Zhang, RAD Bathgate, ... Biochemistry 50 (39), 8352-8361, 2011 | 52 | 2011 |
Site-specific conjugation of a lanthanide chelator and its effects on the chemical synthesis and receptor binding affinity of human relaxin-2 hormone F Shabanpoor, RAD Bathgate, A Belgi, LJ Chan, VB Nair, JD Wade, ... Biochemical and Biophysical Research Communications 420 (2), 253-256, 2012 | 45 | 2012 |
Minimum active structure of insulin-like peptide 5 A Belgi, RAD Bathgate, M Kocan, N Patil, S Zhang, GW Tregear, JD Wade, ... Journal of Medicinal Chemistry 56 (23), 9509-9516, 2013 | 34 | 2013 |
Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity B Van Lierop, SC Ong, A Belgi, C Delaine, S Andrikopoulos, NL Haworth, ... Scientific reports 7 (1), 17239, 2017 | 31 | 2017 |
The chemical synthesis of insulin: from the past to the present A Belgi, M Akhter Hossain, G W Tregear, J D Wade Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Formerly …, 2011 | 31 | 2011 |
α-Conotoxin peptidomimetics: probing the minimal binding motif for effective analgesia AC Kennedy, A Belgi, BW Husselbee, D Spanswick, RS Norton, ... Toxins 12 (8), 505, 2020 | 23 | 2020 |
A naturally occurring peptide with an elementary single disulfide-directed β-hairpin fold SD Robinson, S Chhabra, A Belgi, B Chittoor, H Safavi-Hemami, ... Structure 24 (2), 293-299, 2016 | 20 | 2016 |
Structure and activity of contryphan-Vc2: Importance of the D-amino acid residue SB Drane, SD Robinson, CA MacRaild, S Chhabra, B Chittoor, ... Toxicon 129, 113-122, 2017 | 14 | 2017 |
Preliminary structure–function relationship studies on insulin-like peptide 5 (INSL5) A Belgi, RAD Bathgate, GW Tregear, JD Wade, MA Hossain International Journal of Peptide Research and Therapeutics 19, 71-79, 2013 | 12 | 2013 |
Alkyne-Bridged α-Conotoxin Vc1. 1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models A Belgi, JV Burnley, CA MacRaild, S Chhabra, KA Elnahriry, SD Robinson, ... Journal of Medicinal Chemistry 64 (6), 3222-3233, 2021 | 11 | 2021 |
Probing the correlation between insulin activity and structural stability through introduction of the rigid A6–A11 bond SC Ong, A Belgi, B Van Lierop, C Delaine, S Andrikopoulos, CA MacRaild, ... Journal of Biological Chemistry 293 (30), 11928-11943, 2018 | 10 | 2018 |
Solid phase synthesis of an analogue of insulin, A0: R glargine, that exhibits decreased mitogenic activity SY Kwak, BE Forbes, YS Lee, A Belgi, JD Wade, MA Hossain International Journal of Peptide Research and Therapeutics 16, 153-158, 2010 | 5 | 2010 |
Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins B Krishnarjuna, P Sunanda, J Seow, HS Tae, SD Robinson, A Belgi, ... Marine Drugs 21 (2), 81, 2023 | 2 | 2023 |
Negating coordinative cysteine and methionine residues during metathesis of unprotected peptides W RoyáJackson Chemical Communications 59 (45), 6917-6920, 2023 | 2 | 2023 |
Minimizing mitogenic potency of insulin analogues through modification of a disulfide bond SC Ong, A Belgi, AL Merriman, CA Delaine, B van Lierop, ... Frontiers in Endocrinology 13, 907864, 2022 | 2 | 2022 |
Dicarba modification of α-conotoxin RgIA conferring selectivity towards α9α10 nicotinic acetylcholine receptors SN Kompella, BJ van Lierop, SD Robinson, A Belgi, B Callaghan, A Hung, ... Biochemical Pharmacology 8 (86), 1230, 2013 | 2 | 2013 |