Sarah H Lockie
Sarah H Lockie
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A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
JW Day, N Ottaway, JT Patterson, V Gelfanov, D Smiley, J Gidda, ...
Nature chemical biology 5 (10), 749-757, 2009
Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans
B Finan, T Ma, N Ottaway, TD Müller, KM Habegger, KM Heppner, ...
Science translational medicine 5 (209), 209ra151-209ra151, 2013
Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling
SH Lockie, KM Heppner, N Chaudhary, JR Chabenne, DA Morgan, ...
Diabetes 61 (11), 2753-2762, 2012
Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice
M Tsoli, M Moore, D Burg, A Painter, R Taylor, SH Lockie, N Turner, ...
Cancer research 72 (17), 4372-4382, 2012
Neonatal ghrelin programs development of hypothalamic feeding circuits
SM Steculorum, G Collden, B Coupe, S Croizier, S Lockie, ZB Andrews, ...
The Journal of clinical investigation 125 (2), 846-858, 2015
Ghrelin-induced adiposity is independent of orexigenic effects
D Perez-Tilve, K Heppner, H Kirchner, SH Lockie, SC Woods, DL Smiley, ...
The FASEB Journal 25 (8), 2814, 2011
The temporal pattern of cfos activation in hypothalamic, cortical, and brainstem nuclei in response to fasting and refeeding in male mice
Q Wu, MB Lemus, R Stark, JA Bayliss, A Reichenbach, SH Lockie, ...
Endocrinology 155 (3), 840-853, 2014
Calorie-restricted weight loss reverses high-fat diet-induced ghrelin resistance, which contributes to rebound weight gain in a ghrelin-dependent manner
DI Briggs, SH Lockie, Q Wu, MB Lemus, R Stark, ZB Andrews
Endocrinology 154 (2), 709-717, 2013
A stereological analysis of NPY, POMC, Orexin, GFAP astrocyte, and Iba1 microglia cell number and volume in diet-induced obese male mice
MB Lemus, JA Bayliss, SH Lockie, VV Santos, A Reichenbach, R Stark, ...
Endocrinology 156 (5), 1701-1713, 2015
The endocannabinoid system: role in glucose and energy metabolism
R Nogueiras, A Diaz-Arteaga, SH Lockie, DA Velásquez, J Tschop, ...
Pharmacological research 60 (2), 93-98, 2009
Diet-induced obesity causes ghrelin resistance in reward processing tasks
SH Lockie, T Dinan, AJ Lawrence, SJ Spencer, ZB Andrews
Psychoneuroendocrinology 62, 114-120, 2015
Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice
DI Briggs, SH Lockie, J Benzler, Q Wu, R Stark, A Reichenbach, AJ Hoy, ...
Endocrinology 155 (7), 2411-2422, 2014
The hormonal signature of energy deficit: Increasing the value of food reward
SH Lockie, ZB Andrews
Molecular metabolism 2 (4), 329-336, 2013
Acyl ghrelin acts in the brain to control liver function and peripheral glucose homeostasis in male mice
R Stark, A Reichenbach, SH Lockie, C Pracht, Q Wu, A Tups, ZB Andrews
Endocrinology 156 (3), 858-868, 2015
Des-acyl ghrelin and ghrelin O-acyltransferase regulate hypothalamic-pituitary-adrenal axis activation and anxiety in response to acute stress
R Stark, VV Santos, B Geenen, A Cabral, T Dinan, JA Bayliss, SH Lockie, ...
Endocrinology 157 (10), 3946-3957, 2016
G lucagon‐Like Peptide‐1 Receptor in the Brain: Role in Neuroendocrine Control of Energy Metabolism and Treatment Target for Obesity
SH Lockie
Journal of neuroendocrinology 25 (7), 597-604, 2013
Neural and humoral changes associated with the adjustable gastric band: insights from a rodent model
J Kampe, A Stefanidis, SH Lockie, WA Brown, JB Dixon, A Odoi, ...
International journal of obesity 36 (11), 1403-1411, 2012
Anti-obesity effects of the combined administration of CB1 receptor antagonist rimonabant and melanin-concentrating hormone antagonist SNAP-94847 in diet-induced obese mice
ANA Verty, SH Lockie, A Stefanidis, BJ Oldfield
International journal of obesity 37 (2), 279-287, 2013
AgRP neurons require carnitine acetyltransferase to regulate metabolic flexibility and peripheral nutrient partitioning
A Reichenbach, R Stark, M Mequinion, RRG Denis, JF Goularte, ...
Cell reports 22 (7), 1745-1759, 2018
Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum
A Reichenbach, RE Clarke, R Stark, SH Lockie, M Mequinion, ...
Elife 11, e72668, 2022
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