| Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43 AK Walker, KJ Spiller, G Ge, A Zheng, Y Xu, M Zhou, K Tripathy, ... Acta neuropathologica 130, 643-660, 2015 | 249 | 2015 |
| Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury RS Chung, M Penkowa, J Dittmann, CE King, C Bartlett, JW Asmussen, ... Journal of biological chemistry 283 (22), 15349-15358, 2008 | 188 | 2008 |
| ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation AK Walker, KY Soo, V Sundaramoorthy, S Parakh, Y Ma, MA Farg, ... PloS one 8 (11), e81170, 2013 | 187 | 2013 |
| Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis AK Walker, MA Farg, CR Bye, CA McLean, MK Horne, JD Atkin Brain 133 (1), 105-116, 2010 | 180 | 2010 |
| The pathobiology of TDP-43 C-terminal fragments in ALS and FTLD BA Berning, AK Walker Frontiers in neuroscience 13, 450259, 2019 | 157 | 2019 |
| Stress signaling from the endoplasmic reticulum: A central player in the pathogenesis of amyotrophic lateral sclerosis AK Walker, JD Atkin IUBMB life 63 (9), 754-763, 2011 | 121 | 2011 |
| Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase MA Farg, KY Soo, AK Walker, H Pham, J Orian, MK Horne, ST Warraich, ... Neurobiology of aging 33 (12), 2855-2868, 2012 | 120 | 2012 |
| Defects in optineurin-and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis V Sundaramoorthy, AK Walker, V Tan, JA Fifita, EP Mccann, KL Williams, ... Human molecular genetics 24 (13), 3830-3846, 2015 | 96 | 2015 |
| Extracellular wildtype and mutant SOD1 induces ER–Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells V Sundaramoorthy, AK Walker, J Yerbury, KY Soo, MA Farg, V Hoang, ... Cellular and molecular life sciences 70, 4181-4195, 2013 | 92 | 2013 |
| Mutant SOD 1 inhibits ER‐Golgi transport in amyotrophic lateral sclerosis JD Atkin, MA Farg, KY Soo, AK Walker, M Halloran, BJ Turner, P Nagley, ... Journal of neurochemistry 129 (1), 190-204, 2014 | 90 | 2014 |
| Proteomics approaches for biomarker and drug target discovery in ALS and FTD TJ Hedl, R San Gil, F Cheng, SL Rayner, JM Davidson, A De Luca, ... Frontiers in Neuroscience 13, 459952, 2019 | 80 | 2019 |
| Protein quality control and the amyotrophic lateral sclerosis/frontotemporal dementia continuum H Shahheydari, A Ragagnin, AK Walker, RP Toth, M Vidal, CJ Jagaraj, ... Frontiers in molecular neuroscience 10, 119, 2017 | 78 | 2017 |
| Astrocytic TDP-43 pathology in Alexander disease AK Walker, CMLP Daniels, JE Goldman, JQ Trojanowski, VMY Lee, ... Journal of Neuroscience 34 (19), 6448-6458, 2014 | 78 | 2014 |
| Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations A Konopka, DR Whelan, MS Jamali, E Perri, H Shahheydari, RP Toth, ... Molecular neurodegeneration 15, 1-28, 2020 | 60 | 2020 |
| Bim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic lateral sclerosis KY Soo, JD Atkin, M Farg, AK Walker, MK Horne, P Nagley PloS one 7 (4), e35413, 2012 | 54 | 2012 |
| An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice AK Walker, K Tripathy, CR Restrepo, G Ge, Y Xu, LK Kwong, ... Human molecular genetics 24 (25), 7241-7254, 2015 | 53 | 2015 |
| Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy A Lee, SL Rayner, SSL Gwee, A De Luca, H Shahheydari, ... Cellular and molecular life sciences 75, 335-354, 2018 | 50 | 2018 |
| Mislocalisation of TDP‐43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex MS Dyer, LA Reale, KE Lewis, AK Walker, TC Dickson, A Woodhouse, ... Journal of Neurochemistry 157 (4), 1300-1315, 2021 | 41 | 2021 |
| Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins LK Kwong, DJ Irwin, AK Walker, Y Xu, DM Riddle, JQ Trojanowski, ... Acta neuropathologica communications 2, 1-9, 2014 | 36 | 2014 |
| TDP-43 pathology: from noxious assembly to therapeutic removal SS Keating, R San Gil, MEV Swanson, EL Scotter, AK Walker Progress in neurobiology 211, 102229, 2022 | 35 | 2022 |
