Laurence Hurley
Laurence Hurley
Professor of Medicinal Chemistry, CSO Reglagene
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Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
A Siddiqui-Jain, CL Grand, DJ Bearss, LH Hurley
Proceedings of the National Academy of Sciences 99 (18), 11593-11598, 2002
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
S Balasubramanian, LH Hurley, S Neidle
Nature reviews Drug discovery 10 (4), 261-275, 2011
DNA and its associated processes as targets for cancer therapy
LH Hurley
Nature Reviews Cancer 2 (3), 188-200, 2002
Inhibition of human telomerase by a G-quadruplex-interactive compound
D Sun, B Thompson, BE Cathers, M Salazar, SM Kerwin, JO Trent, ...
Journal of medicinal chemistry 40 (14), 2113-2116, 1997
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex
MY Kim, H Vankayalapati, K Shin-Ya, K Wierzba, LH Hurley
Journal of the American Chemical Society 124 (10), 2098-2099, 2002
G-quadruplex DNA: a potential target for anti-cancer drug design
H Han, LH Hurley
Trends in pharmacological sciences 21 (4), 136-142, 2000
Cationic Porphyrins as Telomerase Inhibitors:  the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA
RT Wheelhouse, D Sun, H Han, FX Han, LH Hurley
Journal of the American Chemical Society 120 (13), 3261-3262, 1998
Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions
Y Qin, LH Hurley
Biochimie 90 (8), 1149-1171, 2008
Making sense of G‐quadruplex and i‐motif functions in oncogene promoters
TA Brooks, S Kendrick, L Hurley
The FEBS journal 277 (17), 3459-3469, 2010
Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells
E Izbicka, RT Wheelhouse, E Raymond, KK Davidson, RA Lawrence, ...
Cancer research 59 (3), 639-644, 1999
The Cationic Porphyrin TMPyP4 Down-Regulates c-MYC and Human Telomerase Reverse Transcriptase Expression and Inhibits Tumor Growth in Vivo
CL Grand, H Han, RM Munoz, S Weitman, DD Von Hoff, LH Hurley, ...
Molecular cancer therapeutics 1 (8), 565-573, 2002
NMR-based model of a telomerase-inhibiting compound bound to G-quadruplex DNA
OY Fedoroff, M Salazar, H Han, VV Chemeris, SM Kerwin, LH Hurley
Biochemistry 37 (36), 12367-12374, 1998
Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G …
D Sun, K Guo, JJ Rusche, LH Hurley
Nucleic acids research 33 (18), 6070-6080, 2005
The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4
J Seenisamy, EM Rezler, TJ Powell, D Tye, V Gokhale, CS Joshi, ...
Journal of the American Chemical Society 126 (28), 8702-8709, 2004
The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of …
D Sun, LH Hurley
Journal of medicinal chemistry 52 (9), 2863-2874, 2009
Interactions of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition
FX Han, RT Wheelhouse, LH Hurley
Journal of the American Chemical Society 121 (15), 3561-3570, 1999
Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 Promoter
TS Dexheimer, D Sun, LH Hurley
Journal of the American Chemical Society 128 (16), 5404-5415, 2006
Selective interactions of cationic porphyrins with G-quadruplex structures
H Han, DR Langley, A Rangan, LH Hurley
Journal of the American Chemical Society 123 (37), 8902-8913, 2001
NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region
J Dai, D Chen, RA Jones, LH Hurley, D Yang
Nucleic acids research 34 (18), 5133-5144, 2006
Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure
EM Rezler, J Seenisamy, S Bashyam, MY Kim, E White, WD Wilson, ...
Journal of the American Chemical Society 127 (26), 9439-9447, 2005
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